XLOC_004468 (tbx6)


Basic Information

Item Value
gene id XLOC_004468
gene name tbx6
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007123.7
NCBI id CM002896.2
chromosome length 49182954
location 3912544 ~ 3923070 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00008949
ATTAGAAGACaagaaacacacagagagagaaggGGAAAAGAAGACTTTGAAAGAGATCTCCTCCATTATAGAAGCTCAGTGAAGCTTTGATTTAATATTCGATAAAGACAAACGTGAAGAAAGAGCAGACCGAGACATGCTGGGTGTGGAAATGTACCCTGGTTTGGCTCTGGGACCTCAGAGATTGAGCGACTGCTATTACAGAGATCGAGATGTGCCGTTGTACCCGTCCACATGTGAGATGGCAGCTCGCGCTCTTCCTCCTGCACTGCTAAAGCCTCATGCAAACACAGACTCTCCTGCCACTCCACAGGACAGCGTGAGGATGGAGCTGGAGAACGCGGGTCTGTGGAAGCAGTTCAGCACAGTCGGGACTGAGATGATCGTCACTAAGAAGGGCAGGCGAATGTTTCCTCAGCTGCGGGTGAAGCTATCAGGGCTGAACCCATCTCTGCGCTACATTCTTCTTCTAGACATCGTACCTGTCGATTCCTCCCGCTATCGTTTTCAAGATAACAGCTGGCAGGTGGTCGGAGGAGCAGAGGCTCGACTGCCGGACCGTGTGTTCATCCATCCGGACTCACCGGCGACTGGAGAACACTGGCAGAACCGCACCATATCCTTCCACCGGGCCAAACTCACCAACAACACGCTGGACGCACAAGGATATATCATTCTTCACTCCTTGCATCGATACCAGCCACGGGTGCATGTGATCGAGGCCCGTGATGTGCTGATGTGGGGAAGAACTCAGCACTCTTTCACTTTTCCTGAAACACAGTTCATTACGGTCACTGCATACCAGAACAACAAGATCACCGAACTGAAAATAAACTCAAATCCTTTTGCGAAAGGCTTTAGAGAGAATGGCATGAACTGCAAGAAGCAAAGAGAGGCAAGGCTGAAGAGGAAAATTACATCCAGCCAAGAGGAATGTTTGGATATTGAGTCATGTGACCCATGTGATTCCACGGAGCTCCTCCCACAATCTGTGGATCTCCCAAGCTCCGCCCTCACCATTATGAACACCGCCCTTCCAATTACAGACTCTGGTTTTCATACAGAAGTGTCATCTCACCCAGATCAGACAGACTCTGACCAAACTCTTGTCCTTGAACAAGCCTTCTTGACCTCTGAGATGCCCTCTTCAATGGAGAGTCAACAACAGACAACCTCTGAAACTAACGTAAACAACGCACTGATGGATGAAACCGGTCAAATGATGGACCTTTCTGGATACACATCATCTTTCCCAACTCCTCAGCTCAGCTCGCATACATCAGTGCCTCAGTCTTCTTCAATGTATTCTGTGGTGTCCTCAACGCAGAGCTCAGACCTTGAGCTTCCACAGGCCTCAAGTATTTCATCTCCACACTCTATGCCTGCATATTCCTCTATACCTTCAGCAGAGTATCCTGGCGTAAATTCCTCTACAGCTATGCCTGCATCTACAACCTCTCTCTCAGACTCATACCCTTCTATCTCACACTCCACCTCTTCACACCTTCTCCAATCTTCATCCTACCATTCTCTTCTTCCAACAGACCAATCCCAAGACAACCTAAGCCCCCATACACCTACAAATCCACCTTTCCAATCAATCCCTGCTTGTCAAGGTACCAGGTTGACTATTGACTCTGGCCAAAATCAGGTGGATGATGGAGGTTTGAGCTCAGCCAATGCGACAACTCCTGCAGTCCCAAACCCAACCCAAACAGCCTTTCCTTTCCCTCCGGTGCAACCCAACAATGACCCTGATCCAACATCCCCTTCATGTCAAAGTCTACCCCAGTCTGCCTTACCATATCAGCAAGTGTCACAATGCAACCAAATTCCCACCCCCTCTGATCCAAATACAACTCCAACCGCATTTCCCTTCCCTCCATCAGAACAGTCCACCCCTAACTCTATTATGGTATCTTCCAATCCAAACACAACAGCCTTCCCCTTTCCCCCTGTTCAGCAGCAACTCAACTTGAGTACCTCTGGACCTAGTTCTTTTCCAGTTTCCCAGTCCTCTGGGTTAAACGCAATTCCAAATCCAGTACATCCAACAACTGGATCATTTTCCTTCCCTTCCACCAGTGCTATCCATCAAGGCCCAATGCAGTCTGTTCCCAACACATTGCACCCTAGCACAGCATACACATTCCCTTCATCTCTGCCCAAACACACTGGTCCTCTCCCAAACCCTGCACCAACTTCTTACCCCTTCCCAACTCCAATCCCACCAGGTCCACATCCTCTCCAGAGTTTGACCCTCCCCTCATCCTGCTCAATCCCGAATACATCCCAAATTCAATCCACCTTTCCCCAGTCATACCATAATCCATCCTTCTCTCACATTCCACCCCAAATGGCAAACCACTCTCAAATCACTTCCCAGTCCTTTCCCCCTCTCCAAACCTCAAGTGCCCCCCAGTTACTATCTCAATCCTCAACTCACCCCCAATGTCCTCCTCCTTCAAACGCATACCCTGCCGTAGCTCCAACTGAGATAGGCACCTTCCCACAACTCAACTCTGCCGCCCCCTATCTACCAGATGTGGTACTGCACCCTTCCATACTTCCTTCTCTCGACCCCTCACTCTCCTCCTCTGCTCCGCCATCCCTTTATAACCCATTTCCTTCCTACTCACTACGTCTTTGCCAGGATCCTCGGTCCTCCCTGCATTTACCCCTCAGGCATATTTATAGACAGCCACAACATGCTCATGGTCAGGGCTCTTACTTTGACCTTGGAGGACGAACAGTGTTCTGAAGAGAAACAGAAACATGACAAGCAAGTCAAGAGCTGGCAAGTGACATGTCTGGTGATGGAAGCACTGCATCGGAGGACCTGTGAGACAACAAGAGATGAACCAAAACACTGTAGTTTAAAGTGTAAAATTTTAAAGTAAACCCTGATTCTGCTGTTCTTGAAATAGTTTCAATGCTTTTGTGTGGTTTTATTCAGAGTAATGCTTGATGAAGTTGAATAATGATGTATATTTTTTTCGTATTTCTCTTCATACCCTTGAATtaccaaataaaattttaatgagtttaa

Function

symbol description
tbx6 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including regulation of skeletal muscle tissue development; somatic motor neuron differentiation; and somitogenesis. Located in chromatin. Is expressed in several structures, including margin; mesoderm; presumptive mesoderm; tail bud; and trunk. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human TBX6 (T-box transcription factor 6).

GO:

id name namespace
GO:0021523 somatic motor neuron differentiation biological_process
GO:0001708 cell fate specification biological_process
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0001756 somitogenesis biological_process
GO:0048514 blood vessel morphogenesis biological_process
GO:0007275 multicellular organism development biological_process
GO:0000122 negative regulation of transcription by RNA polymerase II biological_process
GO:0009952 anterior/posterior pattern specification biological_process
GO:0048641 regulation of skeletal muscle tissue development biological_process
GO:0061053 somite development biological_process
GO:0045944 positive regulation of transcription by RNA polymerase II biological_process
GO:0001947 heart looping biological_process
GO:0000785 chromatin cellular_component
GO:0005634 nucleus cellular_component
GO:0005515 protein binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003700 DNA-binding transcription factor activity molecular_function
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function

KEGG:

id description
ko03000 Transcription factors
ko03019 Messenger RNA biogenesis

ZFIN:

id description
ZDB-GENE-020416-5 Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including regulation of skeletal muscle tissue development; somatic motor neuron differentiation; and somitogenesis. Located in chromatin. Is expressed in several structures, including margin; mesoderm; presumptive mesoderm; tail bud; and trunk. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human TBX6 (T-box transcription factor 6).

Ensembl:

ensembl_id ENSDARG00000011785

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00008949 True 3049 mRNA 0.48 8 3912544 3923070

Neighbor

gene id symbol gene type direction distance location
XLOC_004467 nif3l1 coding upstream 2806 3871452 ~ 3909738 (+)
XLOC_004466 cabp5a coding upstream 50785 3848109 ~ 3861759 (+)
XLOC_004465 pagr1 coding upstream 180530 3723650 ~ 3732014 (+)
XLOC_004464 coa3a coding upstream 337887 3571770 ~ 3574657 (+)
XLOC_004463 g6pc3 coding upstream 601867 3301149 ~ 3310677 (+)
XLOC_004469 NA coding downstream 63009 3986079 ~ 3991423 (+)
XLOC_004470 zgc:123217 coding downstream 113339 4036409 ~ 4044132 (+)
XLOC_004471 NA coding downstream 169382 4092452 ~ 4093573 (+)
XLOC_004472 NA coding downstream 180718 4103788 ~ 4106410 (+)
XLOC_004473 si:dkey-32n7.4 coding downstream 191331 4114401 ~ 4145033 (+)
XLOC_004456 NA non-coding upstream 1140154 2769565 ~ 2772390 (+)
XLOC_004450 NA non-coding upstream 1305512 2578020 ~ 2607032 (+)
XLOC_004444 NA non-coding upstream 1908384 1966673 ~ 2004160 (+)
XLOC_004436 NA non-coding upstream 2834364 1074403 ~ 1078180 (+)
XLOC_004434 NA non-coding upstream 3008892 902588 ~ 903652 (+)
XLOC_004478 NA non-coding downstream 485589 4408659 ~ 4450452 (+)
XLOC_004479 NA non-coding downstream 505053 4428123 ~ 4473148 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000047_04105620_04111019 NA coding CI01000047 null 4105423 ~ 4111184 (-)