XLOC_004516 (dkk1b)


Basic Information

Item Value
gene id XLOC_004516
gene name dkk1b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007123.7
NCBI id CM002896.2
chromosome length 49182954
location 6465557 ~ 6467675 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00009007
GGAACCACAGAAGAGCTCCGCTCACCCAGGGAATACATCCTACAATTCAAGGAATAACATGATGCACATCGCCATGCTCTCTACTGCATGCCTCATTTTTATGGGCTGCATCAAAGTGGCCGGTTCTACGATGCTCAACTCCAACGCTATTAAAGTCGGTTCAGGTGCGGCGGGTGCCAGTCATCCGGTTAGCCCGAGTCCGGACGTGTCACTTTTGGACAGTCTGAACTTCGCCCTCGATACACCGCAGCAGCCTTTAATCTGTGAGAGTGATGAGGAATGCGGTGGAGAGGAGTTTTGCTTCCAGTCTCGCGGTGTCTGTCTCCAGTGCAAGAAGCGCAGGAAGCGCTGCATCCGGGATGCGATGTGCTGCCCTGGCAACCACTGCAGCAATGGTGTTTGCATTCCAAATGACCCTGACATGATTCAGCAGCTTGGCATGGAAGAGTTCGTGTCCATCGCCCATGAAAACTCTACTGCTCTAATGCCGAAAGTTTCGACTCAAGGATCACCACAAAACCAGATGCTGAAAGGTCTGGAGGGAGAGAACTGTCTGAGATCATCAGATTGTGCAGAGGGACTTTGCTGCGCTCGTCACTTTTGGTCCAAAATCTGCAAGCCTGTCCTAAAAGAGGGCCAGGTCTGCACCAAGCACAAGAGGAAAGGCACTCATGGCTTGGAGATATTCCAGCGCTGCGACTGCGGGGAAGGCCTGTCCTGCAGAACGCAGCGAGGAGACGGCGGCAAGGCTTCACGGAGTCTGCACACATGCCAGAGACACTAAATGAAAATTCAAGGAATTTTCTTTCACCAGCTCCCAGAGAAGCAGACTTGAGTCGAGGGAAGCAGGACTTGGAATGGGATACTCTGTTTTTCAACTGGTTTCCTTCATAT
>TCONS_00009008
GCTCCGCTCACCCAGGGAATACATCCTACAATTCAAGGAATAACATGATGCACATCGCCATGCTCTCTACTGCATGCCTCATTTTTATGGGCTGCATCAAAGTGGCCGGTTCTACGATGCTCAACTCCAACGCTATTAAAGTCGGTTCAGGTGCGGCGGGTGCCAGTCATCCGGTTAGCCCGAGTCCGGACGTGTCACTTTTGGACAGTCTGAACTTCGCCCTCGATACACCGCAGCCTTTAATCTGTGAGAGTGATGAGGAATGCGGTGGAGAGGAGTTTTGCTTCCAGTCTCGCGGTGTCTGTCTCCAGTGCAAGAAGCGCAGGAAGCGCTGCATCCGGGATGCGATGTGCTGCCCTGGCAACCACTGCAGCAATGGTGTTTGCATTCCAAATGACCCTGACATGATTCAGCAGCTTGGCATGGAAGAGTTCGTGTCCATCGCCCATGAAAACTCTACTGCTCTAATGCCGAAAGTTTCGACTCAAGGATCACCACAAAACCAGATGCTGAAAGGTCTGGAGGGAGAGAACTGTCTGAGATCATCAGATTGTGCAGAGGGACTTTGCTGCGCTCGTCACTTTTGGTCCAAAATCTGCAAGCCTGTCCTAAAAGAGGGCCAGGTCTGCACCAAGCACAAGAGGAAAGGCACTCATGGCTTGGAGATATTCCAGCGCTGCGACTGCGGGGAAGGCCTGTCCTGCAGAACGCAGCGAGGAGACGGCGGCAAGGCTTCACGGAGTCTGCACACATGCCAGAGACACTAAATGAAAATTCAAGGAATTTTCTTTCACCAGCTCCCAGAGAAGCAGACTTGAGTCGAGGGAAGCAGGACTTGGAATGGGATACTCTGTTTTTCAACTGGTTTCCTTCATATTCTCGAGTCAACATTGAAGAGTAGATTTAATTGTTTCTCAACGGAACTTAAATAAttgcagtaaattactgtattatactgtaaataatataagGCAGTTGGCacttaaatatttttgtcaaCCCTGTTATGAAAGAAGGTGCATCAGTCTTTTCTAGTCTACCTTAAATGTATATACATTCATTCTACAGTCATATAGAGCTGATTTAAATGTctattttattctaaataaagaGTGTACAGATGATATACAGCA

Function

symbol description
dkk1b Predicted to enable co-receptor binding activity and receptor antagonist activity. Acts upstream of or within several processes, including animal organ development; hepatic duct development; and sensory epithelium regeneration. Located in cytoplasm and extracellular region. Is expressed in several structures, including embryonic structure; median fin fold; mesoderm; pharyngeal arch; and sensory system. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1).

GO:

id name namespace
GO:0042074 cell migration involved in gastrulation biological_process
GO:0030178 negative regulation of Wnt signaling pathway biological_process
GO:0007275 multicellular organism development biological_process
GO:0021879 forebrain neuron differentiation biological_process
GO:0090090 negative regulation of canonical Wnt signaling pathway biological_process
GO:0003197 endocardial cushion development biological_process
GO:0043697 cell dedifferentiation biological_process
GO:0061011 hepatic duct development biological_process
GO:0070654 sensory epithelium regeneration biological_process
GO:0001889 liver development biological_process
GO:0048919 posterior lateral line neuromast development biological_process
GO:0007398 ectoderm development biological_process
GO:0030900 forebrain development biological_process
GO:0030334 regulation of cell migration biological_process
GO:0030903 notochord development biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005515 protein binding molecular_function
GO:0039706 co-receptor binding molecular_function
GO:0048019 receptor antagonist activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-990708-5 Predicted to enable co-receptor binding activity and receptor antagonist activity. Acts upstream of or within several processes, including animal organ development; hepatic duct development; and sensory epithelium regeneration. Located in cytoplasm and extracellular region. Is expressed in several structures, including embryonic structure; median fin fold; mesoderm; pharyngeal arch; and sensory system. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1).

Ensembl:

ensembl_id ENSDARG00000045219

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00009007 False 894 mRNA 0.52 4 6465557 6467419
TCONS_00009008 True 1133 mRNA 0.47 4 6465571 6467675

Neighbor

gene id symbol gene type direction distance location
XLOC_004515 NA coding upstream 13948 6195170 ~ 6451609 (+)
XLOC_004514 NA coding upstream 293629 6156963 ~ 6171928 (+)
XLOC_004513 NA coding upstream 312436 6149007 ~ 6153121 (+)
XLOC_004512 NA coding upstream 312978 6144705 ~ 6152579 (+)
XLOC_004511 asah2 coding upstream 322884 6117682 ~ 6142673 (+)
XLOC_004517 CU184911.1 coding downstream 240454 6708129 ~ 6708243 (+)
XLOC_004518 tfam coding downstream 786437 7254112 ~ 7263958 (+)
XLOC_004519 bicc1b coding downstream 931728 7399403 ~ 7429824 (+)
XLOC_004520 FP102277.2 coding downstream 952357 7420032 ~ 7420148 (+)
XLOC_004521 phyhiplb coding downstream 977920 7445595 ~ 7513794 (+)
XLOC_004497 AL929469.3 non-coding upstream 1375627 5089815 ~ 5089930 (+)
XLOC_004522 FQ311940.1 non-coding downstream 1093390 7561065 ~ 7561202 (+)
XLOC_004523 CABZ01050061.1 non-coding downstream 1264859 7732534 ~ 7732650 (+)
XLOC_004524 NA non-coding downstream 1332126 7799801 ~ 7841013 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) G200003 NA unknown CI01000047 null 2316863 ~ 2318962 (+)