XLOC_033050 (vhl)


Basic Information

Item Value
gene id XLOC_033050
gene name vhl
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007117.7
NCBI id CM002890.2
chromosome length 60270059
location 40451270 ~ 40455109 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00064232
ATCATTCTGTCTTCTTCACCGACTCTCACAAGATTACGCAATCAAAACAAACGCAGCCAGCAGCACGGACGTATGTGTGACAGTCACGTACACAGTCTTTCTCTCCGTTCGTGTTATTTTTCAGGTTAAATCAGATCATTGCTTCTTAAGGGCTTAGCGCATGTTCATTATAATTAAAAGAGAGCTTTAACATTTctagtttgtgtatttatgttttgttggGCTTTTTAAAAACGATTAACGTTGAAGCTTTAGTCTAACTCGGTGGAAGCAGGAACTGTCCTGTCTTTGACGATGCCCCAGGACTCTCAGGAGGGGCAGCAGCCGCTCCCGCTGGTCCGGTCTCTGATCAGCCGGATACAGGTCAACGTTCTGTTCTGTAACTGCAGCCCGCGCGTCGTCAAGCCCGTCTGGATCAACTTCCTCGGAGAGCCGCAGCCGTACGTGAACATTCAGCCGTACACCGGACGAAGAATAACAACTTTTGTGGGACATCCATGGATGTTTCGGGATGCAGAAACTGATGATCCAATGGTAGTCAACAATAAAGAGATGTATTTGCCAGCATCTCTTGAAAATGGGCAAGTCGCAAATGCCAAGATCACATTGCCTGTGCTGACGTTGCGAGATCGCTGTCTGCAAGTTGTGAGACGGTTGGTGCGCAGGGAAGATGTCGGCTGTCTGGAGATTGCCCGCTGCCTTCAAGAGGATCTAGCTCAGAGACCCAGCATTCAGGCTGATCTACAACGCATTAGCCAGCGGGTGGAACAGAAGTTACTGGAGAACAGAGAACTGCAAAACAGACGAAAACATCAACATTAACTGGACTGTGCATATGTACTGAGCACACCTGTGCATCAACcaacaatatataaaacaaactatATACTATAGTGCTGTATAACACACAGGGCTGACAAACCAGACGACTGTTTTCTTAATCAGATGGACACTAGATGTTTTAGCTGTTATGATTCATTGACAGGCAGAGACTTGAGAATGCGCAGAGGGAACTTCAGGAAATATGAGTTTTTGTGGTTGTCTGTGTGGCCGGCCTACCAATAGATGAGGACAGAATCTTATTTTggttatttatctgcatactttTACTCAATTACTTTccatttgtttaaataatgtgtaaataaataatggttactatatattttatgttaataatataa

Function

symbol description
vhl Acts upstream of or within several processes, including hemopoiesis; pronephric duct development; and regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be part of VCB complex. Predicted to be active in nucleus. Is expressed in several structures, including lateral mesoderm; liver; nervous system; otic vesicle; and pleuroperitoneal region. Used to study clear cell renal cell carcinoma; familial erythrocytosis 2; and von Hippel-Lindau disease. Human ortholog(s) of this gene implicated in several diseases, including pancreatic cancer (multiple); pheochromocytoma; polycythemia (multiple); renal cell carcinoma; and von Hippel-Lindau disease. Orthologous to human VHL (von Hippel-Lindau tumor suppressor).

GO:

id name namespace
GO:0030097 hemopoiesis biological_process
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway biological_process
GO:0043576 regulation of respiratory gaseous exchange biological_process
GO:0045765 regulation of angiogenesis biological_process
GO:0048793 pronephros development biological_process
GO:0001525 angiogenesis biological_process
GO:0030218 erythrocyte differentiation biological_process
GO:0016567 protein ubiquitination biological_process
GO:0060218 hematopoietic stem cell differentiation biological_process
GO:0039022 pronephric duct development biological_process
GO:0005634 nucleus cellular_component
GO:0030891 VCB complex cellular_component

KEGG:

id description
ko04120 Ubiquitin mediated proteolysis
ko04066 HIF-1 signaling pathway
ko04212 Longevity regulating pathway - worm
ko05200 Pathways in cancer
ko05211 Renal cell carcinoma
ko04121 Ubiquitin system

ZFIN:

id description
ZDB-GENE-070112-1042 Acts upstream of or within several processes, including hemopoiesis; pronephric duct development; and regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be part of VCB complex. Predicted to be active in nucleus. Is expressed in several structures, including lateral mesoderm; liver; nervous system; otic vesicle; and pleuroperitoneal region. Used to study clear cell renal cell carcinoma; familial erythrocytosis 2; and von Hippel-Lindau disease. Human ortholog(s) of this gene implicated in several diseases, including pancreatic cancer (multiple); pheochromocytoma; polycythemia (multiple); renal cell carcinoma; and von Hippel-Lindau disease. Orthologous to human VHL (von Hippel-Lindau tumor suppressor).

Ensembl:

ensembl_id ENSDARG00000070617

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00064232 True 1184 mRNA 0.44 3 40451270 40455109

Neighbor

gene id symbol gene type direction distance location
XLOC_033049 tatdn2 coding downstream 1871 40439858 ~ 40449399 (-)
XLOC_033048 ccdc174 coding downstream 16245 40429773 ~ 40435025 (-)
XLOC_033047 si:dkey-28n18.9 coding downstream 21856 40422224 ~ 40429414 (-)
XLOC_033046 NA coding downstream 42145 40383424 ~ 40409125 (-)
XLOC_033045 ttll3 coding downstream 99055 40329308 ~ 40352215 (-)
XLOC_033051 crbn coding upstream 1689 40456798 ~ 40466861 (-)
XLOC_033052 NA coding upstream 22321 40477430 ~ 40482198 (-)
XLOC_033053 tomm6 coding upstream 117436 40572545 ~ 40573270 (-)
XLOC_033054 tspo coding upstream 123110 40578219 ~ 40583253 (-)
XLOC_033055 CU855953.1 coding upstream 170195 40625304 ~ 40625420 (-)
XLOC_033043 NA non-coding downstream 268750 40173228 ~ 40182520 (-)
XLOC_033038 NA non-coding downstream 407159 40038692 ~ 40044111 (-)
XLOC_033025 CU467856.1 non-coding downstream 925765 39524924 ~ 39525505 (-)
XLOC_033024 NA non-coding downstream 929438 39491846 ~ 39521832 (-)
XLOC_033056 NA non-coding upstream 170522 40625631 ~ 40629161 (-)
XLOC_033058 dre-mir-429b non-coding upstream 198020 40653129 ~ 40653238 (-)
XLOC_033059 dre-mir-141 non-coding upstream 200894 40656003 ~ 40656085 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000340_09637047_09638688 VHL coding CI01000340 null 9636694 ~ 9638688 (-)