XLOC_033051 (crbn)


Basic Information

Item Value
gene id XLOC_033051
gene name crbn
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007117.7
NCBI id CM002890.2
chromosome length 60270059
location 40456798 ~ 40466861 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00064233
CTTGTTCAGAGCGGATTGTAAACACACGGCTATGGCTGCTGAGAGGGGCGGAGGTGACAACAACATTAACGACGAAATGGGGAACCAGCTACAGCTCCTGCCAGaaaatgaagaggaagaggaggatgacATGGAGACGGAGGACAGAGATGGAGAGGATGTGGAAAAGCCAAGTATTATAAACTTTGACACGAGTCTGCCAACTTCACATGCTtATCTTGGCTCAGATATGGAGGAGTTTCACGGCCGTACCCTGCATGATGAGGACAGTGTGCAGAATCTGCCGGTTCTTCCCCATGTGGCTCTCATTCTGATCCCGGGTCAGACACTGCCCTTGCAACTTTTCCGACCACAAGAGGTCAGCATGTTTCGCAACCTCGTAAGCCAGGACCGCACATTCGCAGTGCTTGCACACAGCCCTGATCCGAGTGGAACGGAGACGAAGGCCGAGTTTGGGACGACTGCAGAGATCTATGCATTTCGTGAGGAGCAGGAGTACGGCATTGAGACAGTGAAGATCAAAGCTGTCGGAAGACAACGCTTCAGAGTGCATGAGATACGCACACAAGCAGATGGGATTCGTCAGGCTAAAGTACAGATTTTACCTGAGAGGATTCTGCCGGACCCTTTATGTGCACTGCAGTTCCTGCCACGCTTGCATACACACTCGCcacaaaccaaacacacacaaacaacaccacCACAGAAGCGGTGCAGCCAGAACTATAGACAGaaaaAGCTCCATTGTGCAAGTATGACCTCATGGCCTCCTTGGGTTTATTCCCTTTATGATTCGAAAACTCTCATGAGCAGAGTTAAGAAACAACTGCACGAATGGGATGAAAACCTGAAAGACGAGTCCCTGCCTACAAATCCCACAGATTTCTCCTACAGGGTGGCTGCGTGCCTACCAATAGATGATGCTCTACGACTACAGCTACTGAAGATTGGCAGTGCCATCCAGAGACTGCGCTGTGAGCTGGACATCATGGACAGGtgcacttctcTCTGCTGTAAACAGTGTCAGGATACTGAGATAACCAGCAAGAATGAGATCTTCAGTCTGTCTCTGTATGGGCCAATGGCAGCATATGTGAATCCCCATGGTTATGTTCATGAGACACTTACAGTCTACAAGGCCAGCAACCTCAACCTGATTGGTCGACCTTCCACATTGCATAGTTGGTTTCCAGGGTATGCGTGGACGATTGCTCAGTGCAGAACCTGCAGCTCTCACATGGGCTGGAAGTTCTCTGCAGTCAAAAAGGATCTCAGTCCTCCTCGGTTCTGGGGTTTGACACGTTCTGCTCTGTTACCCACAATCCCACAAGGCGAAGAGGGTGTGGAGGGCTCACGCTTGCTGTGCCTGTGACATGATCCCAGGATACTCTGTGTGACCTTTCACCCTGAAGCCCACAAGCATATGCTCCCCAAGGGGTCTCCTCTATCACTTCTAAAACACGAGACTCCAAAACCTCccccgagagagagagagagagagagagagagagagagagagagagagcacacgTAAGTTCATATGTGTAGATGTGTGCATGAACAGGGAGAGCAAAGAAAAACCAGGGAAGCATAAGATACAGGAGAGGAAAGAACAACAGAACACAAGTTGTTGCCTTCACACACCTTGTGCTGTGTAAATGACAGCCTGATACGTGCAATATCATACCAGATGAGCTCTTTAAGATATTACAATCTGTTGTAATGCACTTAATTTACAGTCTAGCAGTCTTTTCTTCTTTATTACTGCCTAGATAGCTGTCGTTGACGCTCTTTAAGTGAGATTTCATCTAGTTTGGATGTTTATAAAATAAGTATTGTGTTAAAATAGGGATAAATCTCTTACACCAAAGTGTGACGATCTCATTTAGTCATTTTTTAGAGCCCACATGACTTAAGAGACTTAATCATGTATTTGAATACCTCAGATAATTACAGTACGTCTGAAAAAAAGGTCTAAACTGCTTGAAATAAATCATTCTCCACTTGCGATGCCCCATGTTTTTGCTTTGGATACTCTTAGCACAAAACTCCTGGCTAAAATCGGCAGGTGGCGACTTAATGAAATATCAGGGAgtatcttttttttgttgttatttggaCTTGGAAGTCTCGGAAGGTGTTTTgtatttcttagttttttttaggGTTGCTTCATtctttatcatttgtttattttggataCCATTTCATTGAATTGTGGTATGATGCATTTGAGTCGAGAGAAAaaaatagatgtgtgtgtgtgtgtgtgtataagaaaGCAATTGATTTTTACAGTCTGCCTTGAGAAATACTAAAAGTATAAATATTCTGTTGACATGTTCATGAAATGGAATGCAAAATAGACTTTAATTCAGAGAATCAGCACACGTGTACATTCTCGGCTAGTCAGTTAAGTAGCTGTAATAAGAAAACAAGCTGATTTGCATATCTGTGATGTTCAAGAGATTACAAACTGTTCAGTACTGATCAATTCACGCCAATAAACTGCTTCTGAAACGTCAA

Function

symbol description
crbn Predicted to enable metal ion binding activity. Involved in fin development; limb development; and otic vesicle development. Acts upstream of with a positive effect on cell population proliferation. Acts upstream of or within embryonic pectoral fin morphogenesis and otic vesicle morphogenesis. Part of ubiquitin ligase complex. Is expressed in several structures, including cranial vasculature; nervous system; notochord; otic vesicle; and radial glial cell. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human CRBN (cereblon).

GO:

id name namespace
GO:0071600 otic vesicle morphogenesis biological_process
GO:0016567 protein ubiquitination biological_process
GO:0035118 embryonic pectoral fin morphogenesis biological_process
GO:0008283 cell population proliferation biological_process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process biological_process
GO:0000151 ubiquitin ligase complex cellular_component
GO:0005634 nucleus cellular_component
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex cellular_component
GO:0005737 cytoplasm cellular_component
GO:0046872 metal ion binding molecular_function

KEGG:

id description
ko04121 Ubiquitin system

ZFIN:

id description
ZDB-GENE-040822-43 Predicted to enable metal ion binding activity. Involved in fin development; limb development; and otic vesicle development. Acts upstream of with a positive effect on cell population proliferation. Acts upstream of or within embryonic pectoral fin morphogenesis and otic vesicle morphogenesis. Part of ubiquitin ligase complex. Is expressed in several structures, including cranial vasculature; nervous system; notochord; otic vesicle; and radial glial cell. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human CRBN (cereblon).

Ensembl:

ensembl_id ENSDARG00000054250

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00064233 True 2526 mRNA 0.45 11 40456798 40466861

Neighbor

gene id symbol gene type direction distance location
XLOC_033050 vhl coding downstream 1689 40451270 ~ 40455109 (-)
XLOC_033049 tatdn2 coding downstream 7399 40439858 ~ 40449399 (-)
XLOC_033048 ccdc174 coding downstream 21773 40429773 ~ 40435025 (-)
XLOC_033047 si:dkey-28n18.9 coding downstream 27384 40422224 ~ 40429414 (-)
XLOC_033046 NA coding downstream 47673 40383424 ~ 40409125 (-)
XLOC_033052 NA coding upstream 10569 40477430 ~ 40482198 (-)
XLOC_033053 tomm6 coding upstream 105684 40572545 ~ 40573270 (-)
XLOC_033054 tspo coding upstream 111358 40578219 ~ 40583253 (-)
XLOC_033055 CU855953.1 coding upstream 158443 40625304 ~ 40625420 (-)
XLOC_033056 NA coding upstream 158770 40625631 ~ 40629161 (-)
XLOC_033043 NA non-coding downstream 274278 40173228 ~ 40182520 (-)
XLOC_033038 NA non-coding downstream 412687 40038692 ~ 40044111 (-)
XLOC_033025 CU467856.1 non-coding downstream 931293 39524924 ~ 39525505 (-)
XLOC_033024 NA non-coding downstream 934966 39491846 ~ 39521832 (-)
XLOC_033058 dre-mir-429b non-coding upstream 186268 40653129 ~ 40653238 (-)
XLOC_033059 dre-mir-141 non-coding upstream 189142 40656003 ~ 40656085 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000340_09640461_09646025 CRBN coding CI01000340 null 9639816 ~ 9646025 (-)