XLOC_035523 (gclm)


Basic Information

Item Value
gene id XLOC_035523
gene name gclm
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007119.7
NCBI id CM002892.2
chromosome length 54304671
location 15269423 ~ 15277252 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00069677
ATCCGAGAGACGGAGAAACACTGTACCTGAGGGCATTTCACGGTtaatagatacatacatacaagaTTTACTCCCGGCCACCGAGCAATGGAGCATCACGTAAACGCGAAACGGCTTTTCAGTCATGCGACAACGCTGAAGCTTCACACGGGGAATTTAGTGAACCGCAGTCGGCTTAAGAAGAAATGTCCGTCTTCGCCCAGTGAGGAGCTTCAAGACTGCATTCAAGGCACATTGAGCGAGTGGTTCACCGCAATGCCGTCATCCCTTGACTCTGAGCTTCCCAGTGTTTTGGACTGCAGCATTCCTGAAAACACAGAGGCCATCACTCCAGAGGAGAGAGAGGAGCTGAAGGTGTCCGTAAAGCTTTTTCTCACTGAGTGGGACTGCTCATCCATCAGAAGTGCGGTAGACATGGCTTGCCTGTCGTTAGGTGTCTCTCAGTTGGATTCTGTGATCATCGCTCCTCCTTCTCTTCCCGAGGGTGAAAGCCAGACACTGACACACCTGCAGCCTCTCTGGCAGGAGCTGGAGAGTCTGGTGCAGAGCCAGAAGATTGCTGCCATCGGCACCTCAGACCTGGACAAAACCCTCTTGGAGCAGCTCTATAACTGGGCTCAGATAAAGCCAAGCAGTAATCAGGTCAATCTAGCCTCATGCTGTGTGATGCCTCCAGATCTCACTGCATTCGCTAAAGAGTTCGACATTCAGTTGCTGACACACAGTGACCCCAAAGAGCTCATCAGTGCAGCAGGTTTTCAGGAGGCGGTGCAGGGCAGCAGTCAGGAGCTGCAGGTGGACGACTGGAGGCTGGAGTGGGTTTTGCGCTACTCCATTATCGTCAAGAGCAGAGGCATCATAAAAGCAAAGGGCTACATTGTTCATGCTAAAAAGAGCAACAACCATTAACTGGGCTTTTCGGCTTCCTCAAATTTATTCCACCAAACTGTTGTCCTCTATTACATCATTGATGGGTGGCTTCGTCAGCACACTAAAGTGAATTTGAGTTATCCGAGGaacaaaaaaaatcacttgaTGCATTTTTCCTGATGATTTCAATTATTTAGACAGCGAGCTGTTTGTGTAGAAACATGCAAAGTGCCtgcttttctgttgttgttttttttgttgactTTGCCTGGTTTAATTTGCAGTAATTATCCAATAGGTTGATGGGATAGAAAATCAGGATTTAAGAACCAAAAGGTTGTTTTTGTAATCAAATATTTTAAGTACAGGGCCTGTTTTAATGTTCCCGTGACCTTGttttcaggagaaaaaaaaaagacattcacACCCTTATGCCCTTATGGTTGTgttgaaaactttttttatttcaagaagTTTACCACAGAGATTTGTTTCCGAattagttttagatttttttaatcttttaattttaaTGTCCTGCTGGCGTTTTTTATGTTcgtataatttattttttgctttgcttggaattatttttattatcattttatctCTTTTGCATCCCTTTGCTTTGCTTAcctgagataaaataaatattaaggtaTGTAACTGTATGCTGTTAAAATGCATGGCATAAACAGCCTTGAttcattgtgtatataaaaacactgGAAACAAAAGTCCACACTTGAAGAATACCAAGGCTTATCGCTCCAGTATGGAGTGAGTAGTCAGAGTATATATTTTTACCtgtgttatttattcattgtaaTGGCAATTCCTGTTGGATCCAATCCTATAAGAGAGATTGTTTCTTGTACTGTACATGTAATTACTATTTTCCCATATTGTGATGAACATTTTTAATCTGGTTTATAAACTTCGCAATTGAAAATGGA
>TCONS_00069678
GTTGTAGTGTTGCTAGACATCCTTTCACAGCATTTACCTAGACATTTGATTTTTCGTGAATGATGTGGAATTTATGGTTTCATATTTTGGTTTTCGACGAATATGTCCAATTATTGAGTGTACTAATGTGTAATTCGATTGTGCTATTTTGTAATTGGATTGATGATACAACGTTAAAATTTCTCTTTAGCTTCAAGACTGCATTCAAGGCACATTGAGCGAGTGGTTCACCGCAATGCCGTCATCCCTTGACTCTGAGCTTCCCAGTGTTTTGGACTGCAGCATTCCTGAAAACACAGAGGCCATCACTCCAGAGGAGAGAGAGGAGCTGAAGGTGTCCGTAAAGCTTTTTCTCACTGAGTGGGACTGCTCATCCATCAGAAGTGCGGTAGACATGGCTTGCCTGTCGTTAGGTGTCTCTCAGTTGGATTCTGTGATCATCGCTCCTCCTTCTCTTCCCGAGGGTGAAAGCCAGACACTGACACACCTGCAGCCTCTCTGGCAGGAGCTGGAGAGTCTGGTGCA

Function

symbol description
gclm Predicted to enable enzyme regulator activity. Predicted to be involved in glutathione biosynthetic process and positive regulation of glutamate-cysteine ligase activity. Predicted to be part of glutamate-cysteine ligase complex. Is expressed in several structures, including brain; germ ring; immature eye; liver; and pronephric duct. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit).

GO:

id name namespace
GO:0035229 positive regulation of glutamate-cysteine ligase activity biological_process
GO:0006750 glutathione biosynthetic process biological_process
GO:0017109 glutamate-cysteine ligase complex cellular_component
GO:0035226 glutamate-cysteine ligase catalytic subunit binding molecular_function
GO:0030234 enzyme regulator activity molecular_function
GO:0016874 ligase activity molecular_function

KEGG:

id description
ko00270 Cysteine and methionine metabolism
ko00480 Glutathione metabolism
ko04216 Ferroptosis

ZFIN:

id description
ZDB-GENE-030131-5906 Predicted to enable enzyme regulator activity. Predicted to be involved in glutathione biosynthetic process and positive regulation of glutamate-cysteine ligase activity. Predicted to be part of glutamate-cysteine ligase complex. Is expressed in several structures, including brain; germ ring; immature eye; liver; and pronephric duct. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit).

Ensembl:

ensembl_id ENSDARG00000018953

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00069677 False 1826 mRNA 0.42 7 15269423 15277252
TCONS_00069678 True 525 processed_transcript 0.45 5 15269863 15275437

Neighbor

gene id symbol gene type direction distance location
XLOC_035522 slc5a9 coding upstream 491 15254564 ~ 15268932 (+)
XLOC_035521 zgc:171480 coding upstream 15623 15251448 ~ 15253800 (+)
XLOC_035520 paox1 coding upstream 19158 15239549 ~ 15250265 (+)
XLOC_035519 fnbp1l coding upstream 188850 14986833 ~ 15080573 (+)
XLOC_035518 abl2 coding upstream 284147 14915332 ~ 14985276 (+)
XLOC_035524 dnttip2 coding downstream 622 15277874 ~ 15286309 (+)
XLOC_035525 BX510319.1 coding downstream 199373 15476625 ~ 15479807 (+)
XLOC_035526 elavl4 coding downstream 726902 16004154 ~ 16117112 (+)
XLOC_035527 NA coding downstream 982334 16259586 ~ 16265811 (+)
XLOC_035528 cdkn2c coding downstream 1130632 16407884 ~ 16414886 (+)
XLOC_035515 CR450798.1 non-coding upstream 463133 14806174 ~ 14806290 (+)
XLOC_035513 NA non-coding upstream 616773 14612986 ~ 14652650 (+)
XLOC_035512 NA non-coding upstream 707993 14558645 ~ 14561430 (+)
XLOC_035511 BX294388.1 non-coding upstream 853600 14415698 ~ 14415823 (+)
XLOC_035509 NA non-coding upstream 1023070 14241585 ~ 14246353 (+)
XLOC_035529 NA non-coding downstream 1286701 16563953 ~ 16582042 (+)
XLOC_035530 NA non-coding downstream 1293084 16570336 ~ 16577809 (+)
XLOC_035531 NA non-coding downstream 1332426 16609678 ~ 16613471 (+)

Expression


Co-expression Network