XLOC_035978 (mthfr)


Basic Information

Item Value
gene id XLOC_035978
gene name mthfr
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007119.7
NCBI id CM002892.2
chromosome length 54304671
location 47219107 ~ 47252552 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00070474
CGTCCATGCTATCCGCACATGCTGTTTAGCCAGAGATCAAGCACAGAGCCTCCCTGGGACTGCAGTCTCCTTTCATAAGCTCTGGCGAATCGGGAAAAGGGAAATATGGTGAACCAAAGAGCTGACGTGGGTTGGCACTCTAAGAGTGATTCCAGCGGGGCCAGTAACAGTGGAGAGAGCTCCAGAGAGAGCTCCAGATGCTCCACCCCAGTACCGGACGCTGACCGCACCGACCGGCTACGGGACAAAATGAAACGACGTATCGAGTCAGGGGATCACTGGTTCTCTTTAGAGTTCTTCCCACCTCGCACATCGTCTGGAGCGGTCAATCTTATCTCTAGATTTGACCGAATGGGTTCCGGAGGCCCTCTCTTCATTGACATCACTTGGCATCCCGCTGGAGATCCGGGCTCAGATAAAGAAACGTCTTCCATGATGATAGCAAGCACAGCGGTCAACTATTGCGGTCTGGAGAGTGTCCTGCATTTAACATGCTGCAATCAGACAAAGGAGAAAATAACAGACCATTTAAATAAAGCCAAGCGGCTCGGCCTAAAGAATATCATGGCCCTGAGAGGAGATCCTGTTGGGGAAGATTGGGTGGAGGAAGATGGTGGTTTTAACTTTGCGACAGATCTGGTCAAACACATTCGCCATGAATTCGATGACTACTTTGATATCTGTGTAGCAGGTTACCCCACGGGTCACCCGGAGGCTGAGAGCTATGAAGATGACCTCCGGCACTTGAAGGAGAAGGTTGATGCTGGAGCACACTTCATCGTCACCCAGCTGTTTTTCAGAGCAGAAACCTTCCTTAAGTTTGTCAAAGACTGTCGAGCCATTGGCATCACCTGCCCGATTCTTCCAGGAATCTTCCCCATCCAGGGTTATCATTCACTCCGCCAGCTGGTCAAACTCTCCAAACTTGAAGTGCCGGAGGAGATCAAGCAAGTGATTGAGCCCATTAAGGATAATGATGCCGCTATCCGGAACTACGGCATCCAGCAGGCTGTAGAGATGTGTAAAGTTCTGCTGGCCAGTGGGGAAGTCTCCGGCCTGCACTTTTACACCTTAAACCGAGAGGTGGCCACCATGGAAGTGCTCAGGCAGCTGGGATTATGGGCAGAGGATCCACGGCGACCTCTGCCCTGGGCCATCAGCGCCCACCCAAAGCGTAAGGTAGAAGACGTCAGGCCAATTTTCTGGGCTTCCCGACCCAAAAGCTACATCTACAGAACACAAGACTGGGATGATTTCCCTAACGGAAGATGGGGGAACTCTTCTTCACCAGCCTTTGGCGAGTTGACGGATTATTACTTGTTCTACCTGAAGAGTAAGTCTCCTAAAGAGGCGCTGCTGCAGATGTGGGGAGAGGAGCTCATGAGCGAAGAGAGCGTTTATGAAGTCTTTACCAACTACATCACTGGACAAACCAACCGCAGTGGACACAAGGTGATGTGTCTGCCATGGAACGACGATCCTCTGGCTCCAGAAACCAACCTGCTGAAGGATGAGCTGGAGAAGGTGAACCGCAGAGGTGTTCTCACCATTAACTCTCAACCCAACATCAATGGCAAAGCCTCTTCTGATGCGATCGTGGGCTGGGGTCCTGCAGGAGGATACGTCTTTCAAAAGGCGTATTTGGAGTTTTTCACATCAAGTGAAAACGTTACTGCGCTTCTGCAAGTGCTGAAGAAATATGAACCACGTGTGAACTACCAAATAGTCAATGTGCAGggcAGGAATATCACAAACGCCCATGATATGCAGCCCAACGCTGTGACATGGGGGATTTTCCCAGGCAGAGAGATCATTCAGCCCACTGTGGTGGATCCAGTCAGCTTTATGTACTGGAAGGACGAGGCTTTCGCGTTGTGGATTGAACAATGGGCGAAGCTATACGAGGACGAATCGCCCTCGCGCATGATCATTCAGTACATCCACGACAACTACTTTCTGGTCAATCTGGTGGACAACGACTTCCCGCTCGACAACTGTCTGTGGCAGGTGATCGAAGACATGTTTGCGCTCCTGGACTCTTCTCAAGTACCGCAGCAGGAGGCAAATGAATTGTAGCACCACTATTCGCTGCTATTTGATCCAGAGACGTCTGAACGCACACTTTACTGTAATGGcacagtgtttttttgttttgtttttttagtcatTATCAGCACTTAATTCTTTGTCAGTATATTGGGGGAAAAGTGACAAACGTAGCACTATACTcgatgatttgccttaatctttAAAGAGACTTAAGTTAGCCGGTTTGGGTGGCGTTTTCTTATATTTTAAGCTTGATTTTTACCTATTTATAGACAGTATTTTGGATACTGCAGATGTATTGA
>TCONS_00070475
GCACATGCTGTTTAGCCAGAGATCAAGCACAGAGCCTCCCTGGGACTGCAGTCTCCTTTCATAAGCTCTGGCGAATCGGGAAAAGGGTAAGGAAATATGGTGAACCAAAGAGCTGACGTGGGTTGGCACTCTAAGAGTGATTCCAGCGGGGCCAGTAACAGTGGAGAGAGCTCCAGAGAGAGCTCCAGATGCTCCACCCCAGTACCGGACGCTGACCGCACCGACCGGCTACGGGACAAAATGAAACGACGTATCGAGTCAGGGGATCACTGGTTCTCTTTAGAGTTCTTCCCACCTCGCACATCGTCTGGAGCGGTCAATCTTATCTCTAGATTTGACCGAATGGGTTCCGGAGGCCCTCTCTTCATTGACATCACTTGGCATCCCGCTGGAGATCCGGGCTCAGATAAAGAAACGTCTTCCATGATGATAGCAAGCACAGCGGTCAACTATTGCGGTCTGGAGAGTGTCCTGCATTTAACATGCTGCAATCAGACAAAGGAGAAAATAACAGACCATTTAAATAAAGCCAAGCGGCTCGGCCTAAAGAATATCATGGCCCTGAGAGGAGATCCTGTTGGGGAAGATTGGGTGGAGGAAGATGGTGGTTTTAACTTTGCGACAGATCTGGTCAAACACATTCGCCATGAATTCGATGACTACTTTGATATCTGTGTAGCAGGTTACCCCACGGGTCACCCGGAGGCTGAGAGCTATGAAGATGACCTCCGGCACTTGAAGGAGAAGGTTGATGCTGGAGCACACTTCATCGTCACCCAGCTGTTTTTCAGAGCAGAAACCTTCCTTAAGTTTGTCAAAGACTGTCGAGCCATTGGCATCACCTGCCCGATTCTTCCAGGAATCTTCCCCATCCAGGGTTATCATTCACTCCGCCAGCTGGTCAAACTCTCCAAACTTGAAGTGCCGGAGGAGATCAAGCAAGTGATTGAGCCCATTAAGGATAATGATGCCGCTATCCGGAACTACGGCATCCAGCAGGCTGTAGAGATGTGTAAAGTTCTGCTGGCCAGTGGGGAAGTCTCCGGCCTGCACTTTTACACCTTAAACCGAGAGGTGGCCACCATGGAAGTGCTCAGGCAGCTGGGATTATGGGCAGAGGATCCACGGCGACCTCTGCCCTGGGCCATCAGCGCCCACCCAAAGCGTAAGGTAGAAGACGTCAGGCCAATTTTCTGGGCTTCCCGACCCAAAAGCTACATCTACAGAACACAAGACTGGGATGATTTCCCTAACGGAAGATGGGGGAACTCTTCTTCACCAGCCTTTGGCGAGTTGACGGATTATTACTTGTTCTACCTGAAGAGTAAGTCTCCTAAAGAGGCGCTGCTGCAGATGTGGGGAGAGGAGCTCATGAGCGAAGAGAGCGTTTATGAAGTCTTTACCAACTACATCACTGGACAAACCAACCGCAGTGGACACAAGGTGATGTGTCTGCCATGGAACGACGATCCTCTGGCTCCAGAAACCAACCTGCTGAAGGATGAGCTGGAGAAGGTGAACCGCAGAGGTGTTCTCACCATTAACTCTCAACCCAACATCAATGGCAAAGCCTCTTCTGATGCGATCGTGGGCTGGGGTCCTGCAGGAGGATACGTCTTTCAAAAGGCGTATTTGGAGTTTTTCACATCAAGTGAAAACGTTACTGCGCTTCTGCAAGTGCTGAAGAAATATGAACCACGTGTGAACTACCAAATAGTCAATGTGCAGggcAGGAATATCACAAACGCCCATGATATGCAGCCCAACGCTGTGACATGGGGGATTTTCCCAGGCAGAGAGATCATTCAGCCCACTGTGGTGGATCCAGTCAGCTTTATGTACTGGAAGGACGAGGCTTTCGCGTTGTGGATTGAACAATGGGCGAAGCTATACGAGGACGAATCGCCCTCGCGCATGATCATTCAGTACATCCACGACAACTACTTTCTGGTCAATCTGGTGGACAACGACTTCCCGCTCGACAACTGTCTGTGGCAGGTGATCGAAGACATGTTTGCGCTCCTGGACTCTTCTCAAGTACCGCAGCAGGAGGCAAATGAATTGTAGCACCACTATTCGCTGCTATTTGATCCAGAGACGTCTGAACGCACACTTTACTGTAATGGcacagtgtttttttgttttgtttttttagtcatTATCAGCACTTAATTCTTTGTCAGTATATTGGGGGAAAAGTGACAAACGTAGCACTATACTcgatgatttgccttaatctttAAAGAGACTTAAGTTAGCCGGTTTGGGTGGCGTTTTCTTATATTTTAAGCTTGATTTTTACCTATTTATAGACAGTATTTTGGATACTGCAGATGTATTGAAGCAGGTCAAAATGTGTGGACAGAGAATACGGAATGTGGATACTGTATTTTCACTCAGGTGAATCTTATGTCAGGTCATATTTCTCTCAACATTCTAGAGAACATTTAGATTTACTAAACGCCCTTAGAGAAGAATATAGTGCTGCACACAGCTATTTTAGCTCTTAACTCTAATTAATGTGCATTTGTAAGAGATTCCCGTTAAGTTGCTAATGGTATCGGCAGTATTTAAACAGATCACGTAAAACGATTAACAAACTTTCAACTTATGGTCATTTGCTATATTATTCAATGCCTAAAACTAAGCATGTCATATATTGTGTTTTCACCAAACACTGCGTCACTTGctctagtgatgggaagtttggatcattttactgactgattcgagatgaacgaatcttttttcgagtcatttcgttcatttggttcaatttgccaaaatattattaaaatgttacgagttgcttccaaacacatctacaactagcccaaaaggttgatcgcATGACAAATAAGTCATGAATAGAATACGATaataaggagaaaataataattcagtgtttacctgctcttttgtctacgACGGTATtattgtctctttgctcagctcacctctttatGTCCTCAAATGTTAGTGGTTCGTTcatgttacactgacagtcacatttAATCTTAATCAATGTACACAGTCTCAgagtcgataggagccatgataattagttcacctttaaGTCTTCtcgttcgttcatcatgtgacagaatgactcccgaaagaggactcgagagatgaacggatcaattctttttccagctctaaacgcatatgattggcttctgcctttccgcgatgaacgactcaaGACTTGAAaggaacgataccacctgcacaaatgtgcgcacgcgcggatgaacgaatcgctccctgagaggactcgtaattcccgagtcatattgaagattcattcaaaatgaacgaatcgctcatgaacgacccatcactaactTGCTCTCGTTTACCCAGGGGATGTTTTTCCCCTAAATACActgaaattacaaaaattaaatttttttttttaagtcaagtaGTTGCAAACaaataggctgaatttaaacaaacaaagttgAGCATAACCAAATTTAATTCAaacaaaaattgtaacaaactTTTTTGGATATTTAGTGGAATCGTTTAGCCAAAATTGAATACTCGTATTGGAAAACCAACATTTTTGTTTAACTATGGAAAGCAAGCGAATATTTTAAGACACAAAAAACTACAAGATGGAGACGGTTTAATTCAAGTCGAGACagttgttttatataaatattgtttaaacatGGATAAACGCACATCTGTTAGATGAGCACCAATGTGTGCTTTGTATTCGAGAACCTATGAGGTTTATCTGCAAGAACAATGACCCATGTCTGTCAATAAAAGCCTAAATGAAATTACTCAGACGGAAA

Function

symbol description
mthfr Predicted to enable FAD binding activity and methylenetetrahydrofolate reductase (NAD(P)H) activity. Predicted to be involved in methionine biosynthetic process and tetrahydrofolate interconversion. Predicted to act upstream of or within methionine metabolic process. Predicted to be active in cytosol. Is expressed in anterior neural tube; optic cup; and somite. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); and kidney failure (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase).

GO:

id name namespace
GO:0009086 methionine biosynthetic process biological_process
GO:0006730 one-carbon metabolic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0006555 methionine metabolic process biological_process
GO:0035999 tetrahydrofolate interconversion biological_process
GO:0005829 cytosol cellular_component
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0071949 FAD binding molecular_function

KEGG:

id description
ko00720 Carbon fixation pathways in prokaryotes
ko00670 One carbon pool by folate
ko01523 Antifolate resistance

ZFIN:

id description
ZDB-GENE-041111-215 Predicted to enable FAD binding activity and methylenetetrahydrofolate reductase (NAD(P)H) activity. Predicted to be involved in methionine biosynthetic process and tetrahydrofolate interconversion. Predicted to act upstream of or within methionine metabolic process. Predicted to be active in cytosol. Is expressed in anterior neural tube; optic cup; and somite. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); and kidney failure (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase).

Ensembl:

ensembl_id ENSDARG00000053087

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00070474 False 2351 mRNA 0.49 12 47219107 47251082
TCONS_00070475 True 3812 mRNA 0.44 12 47219121 47252552

Neighbor

gene id symbol gene type direction distance location
XLOC_035977 si:dkeyp-100a1.6 coding upstream 21235 47188154 ~ 47197872 (+)
XLOC_035976 CR792439.1 coding upstream 60074 47154662 ~ 47159033 (+)
XLOC_035975 arhgef16 coding upstream 75279 47099033 ~ 47143828 (+)
XLOC_035972 espn coding upstream 130579 46939391 ~ 47088528 (+)
XLOC_035979 NA coding downstream 3556 47256108 ~ 47259810 (+)
XLOC_035980 plch2a coding downstream 90034 47342586 ~ 47622532 (+)
XLOC_035981 si:ch211-251b21.1 coding downstream 380886 47633438 ~ 47665026 (+)
XLOC_035982 dpp9 coding downstream 424656 47677208 ~ 47723544 (+)
XLOC_035983 CU499311.1 coding downstream 445546 47698098 ~ 47698470 (+)
XLOC_035974 BX000472.1 non-coding upstream 146770 47072220 ~ 47072337 (+)
XLOC_035973 BX000472.2 non-coding upstream 158592 47060401 ~ 47060515 (+)
XLOC_035971 FO704898.1 non-coding upstream 452562 46766429 ~ 46766545 (+)
XLOC_035970 NA non-coding upstream 509259 46708220 ~ 46709848 (+)
XLOC_035989 NA non-coding downstream 765099 48017651 ~ 48018967 (+)
XLOC_035991 CR381598.1 non-coding downstream 922756 48175308 ~ 48175423 (+)
XLOC_035992 NA non-coding downstream 1135020 48387572 ~ 48390135 (+)
XLOC_035993 CABZ01070222.1 non-coding downstream 1138010 48390562 ~ 48390678 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000050_06343875_06352994 MTHFR coding CI01000050 null 6343319 ~ 6354241 (+)
bowfin (Amia calva) AMCG00002211 mthfr coding CM030136.1 CM030136.1 7178439 ~ 7191115 (+)