XLOC_037155 (itm2bb)


Basic Information

Item Value
gene id XLOC_037155
gene name itm2bb
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007120.7
NCBI id CM002893.2
chromosome length 56459846
location 25330905 ~ 25346583 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00073145
acacacaaacattgctGCTGATCAGGAAACTGAACACTTTCATTTTGCGAACTCTCTGCTCTCTGTCGCACTTCTCAcggaaaaaaaacaacttactTTTCAGAATGGTAAAAGTTTCTTTTAACAAGGCTTTCGCCCTAAAGGATCCAAAAAAGGAAACTCTCATTAACGAAGAACAGGACCCAGAGGCAGTGGTGCTGGTGCGTCATCAGTCTCGGGTGTGGTGCTGGTGCTTCTGTCTGGGATTGACTCTTGTGCTTTCTGGCGTTGTGGTGGCAGGAGCCTATCTGTATAGGTACTATGTGTTAGAGAGGGACCAGGTGTTTATCTGTGGGCTGAAGTACTACGAGGAAGACTATGAGCTGAATGAAGAGGTGGACCCAGAAATTGGAGCACCGCTGAGGCTGATTGAGGAGAATGTCAGCTTTTTTGAAGATGATGAGGTGGAGCTCATCAGTGTACCAGTGCCAGAGTTCAAAGACAGCGATCCAGCTGGCATCCTGCACGACTTCACCATGAAACTGACTGCTTATCTCGACCTGAATCTGGACAAATGCTACATCATCACTCTCAACACCTCAGTTGTAATGCCACCAAGAGACTTTCAGGAGTTCCTGGTCAACATCAAGgaAGGAATGTATCTTCCTCAGACATACCTGATCCATGAGGAGATGATGGTGACAGAGAAGCTGGACGACACCAGTGATCTGGGCTATTACATCAATAACCTGTGCAAAGACAAAGACACGTACAGACTGCAGCGCAGAGACACCATTCTGGGTATGCAGAAGCGCGAGGCTCTGAACTGCCACAAGATCCGCCATTTTGAAAACAAGTTTGTTGTGGAGACTTTGATCTGCGAGCCATGAAGAGCACATGAGCATCTCTGACAACAACAGCAGATCTACAACACCAAATTAACGCAGTCGAACGCTTTCCTTCTGTAGCTGTTTATTTTCAAGCTTTCttcttctgtgtggagtttgtttatTCTTATCTGAAATGTGAATGTTTTCTAGATACAGGTGTattatgttttgtgtttgtatatgtttgtttttttcttaagcTATTTGTGTGAATTTCAGATTAACGAAAGAGTTATTTTGTGCACAAGAACAAAAAGGGATTAGCAATAACTACTTTTGGCTTAACTACAAATCAGATCAGCGTTTAGAAAgtgatttaataattcatttattcccaTGAGCTGCTGAAATGGATCAATTAATTTGCTTAATGAATAGTGActgctgttttagtttttttactatTTGAAATTAGAATACAGAGTGAAGAAGCATCGTCATCACTGTCTCTCAGCTGTGAATCTGCAAATTAGAAATGCTCAATTTTACACAAATATTACAAGTGAAATCTCCTTTAGTTCTTGGctgatttgtatttaataaactgTCTGTAAGATCCTCCATTTTACACATCTTCAGTTTTTCTGTTTTCAGATACAAGCTCCTTAAAtctaataaaactaaaatttaacaaaa
>TCONS_00073146
CGCACTTCTCAcggaaaaaaaacaacttactTTTCAGAATGGTAAAAGTTTCTTTTAACAAGGCTTTCGCCCTAAAGGATCCAAAAAAGGAAACTCTCATTAACGAAGAACAGGACCCAGAGGCAGTGGTGCTGGTGCGTCATCAGTCTCGGGTGTGGTGCTGGTGCTTCTGTCTGGGATTGACTCTTGTGCTTTCTGGCGTTGTGGTGGCAGGAGCCTATCTGTATAGGTACTATGTGTTAGAGAGGGACCAGGTGTTTATCTGTGGGCTGAAGTACTACGAGGAAGACTATGAGCTGAATGAAGAGGTGGACCCAGAAATTGGAGCACCGCTGAGGCTGATTGAGGAGAATGTCAGCTTTTTTGAAGATGATGAGGTGGAGCTCATCAGTGTACCAGTGCCAGAGTTCAAAGACAGCGATCCAGCTGGCATCCTGCACGACTTCACCATGGTATACCAAATATACAAagttacacacacatatatttgtaCAGCTAATCTTTTTTGGGACTTCGATTGTTTTTATATATagcaaaaagtgttttttattctttaaactaGAGCAAAAATTAAC

Function

symbol description
itm2bb Predicted to enable amyloid-beta binding activity. Predicted to be involved in negative regulation of amyloid precursor protein biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in blood; macrophage; pronephric duct; ventral mesenchyme; and yolk syncytial layer. Human ortholog(s) of this gene implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Orthologous to human ITM2B (integral membrane protein 2B).

GO:

id name namespace
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process biological_process
GO:0005794 Golgi apparatus cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0001540 amyloid-beta binding molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-040426-2139 Predicted to enable amyloid-beta binding activity. Predicted to be involved in negative regulation of amyloid precursor protein biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in blood; macrophage; pronephric duct; ventral mesenchyme; and yolk syncytial layer. Human ortholog(s) of this gene implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Orthologous to human ITM2B (integral membrane protein 2B).

Ensembl:

ensembl_id ENSDARG00000041505

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00073145 False 1505 mRNA 0.40 6 25330905 25346583
TCONS_00073146 True 575 processed_transcript 0.43 3 25330971 25337727

Neighbor

gene id symbol gene type direction distance location
XLOC_037154 lrch1 coding upstream 159493 25096500 ~ 25171412 (+)
XLOC_037153 NA coding upstream 250600 25079163 ~ 25080305 (+)
XLOC_037152 BX323457.2 coding upstream 256706 25073539 ~ 25074199 (+)
XLOC_037151 BX323457.3 coding upstream 263175 25066661 ~ 25067730 (+)
XLOC_037150 slc39a10 coding upstream 379243 24920677 ~ 24951662 (+)
XLOC_037156 NA coding downstream 219157 25565740 ~ 25837749 (+)
XLOC_037157 gtdc1 coding downstream 494137 25840720 ~ 25913984 (+)
XLOC_037158 CR925716.1 coding downstream 510030 25856613 ~ 25856729 (+)
XLOC_037159 NA coding downstream 682148 26028731 ~ 26032109 (+)
XLOC_037160 arglu1a coding downstream 739552 26086135 ~ 26096626 (+)
XLOC_037148 BX571803.4 non-coding upstream 903665 24423792 ~ 24427240 (+)
XLOC_037147 BX571803.2 non-coding upstream 943374 24384134 ~ 24387531 (+)
XLOC_037162 NA non-coding downstream 838505 26185088 ~ 26191424 (+)
XLOC_037164 NA non-coding downstream 1224646 26571229 ~ 26574876 (+)

Expression


Co-expression Network