XLOC_004474 (itgam)


Basic Information

Item Value
gene id XLOC_004474
gene name itgam
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007123.7
NCBI id CM002896.2
chromosome length 49182954
location 4147714 ~ 4157240 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00008953
ATGATGGATTGGTACTCCTATATCAGTTTTTGCATCTTCTGTGTGTCTCAGTCGGTCATGGCTTTTAACATCGATCCTGCCAGCTGGAAAACTTTCACTGGACCTTCACAGAGCCAAAATGTTGCCTTTGGCTACAAGGTGATACAGAAAGACACATCAAGTCTGATCGTGAGCGATCCTTTAATTCAAATCAACCAGGATAAAAGAGGACAAATTTATAACTGTGAGGTTGCAAAAGGAACCTGCACACAACTGAACATTACCGTGCCCTCAGAAGCTGTCAACATGTCTCTGGGATTCTCCATGGTTCAACATCCACAATCTTCAAAGCTGGCAATTTGTGGTCCTACCATTCCAAAGAATTGTACAACAGCTACCAACTACAGAGGCATGTGCTTTATTGGGAACAGTGGGGATTTTGGACCACCAATACCCAAATCCAAATACAGAGACTGTCTTGGTCAGATTGACATAGCTTTTCTACTGGATGGCTCTGGGAGTATAGGAATTTATGATTTTACAGTAATGAAGGGTTTTGTGACAAACGTGATCAGACGTTTTATTGAGCGGGATGCACAGTTTGCCATTGCACAGTACTCCAATGACTGTGATATTCACTACAATTTCAATGACCTCAAATTAGATGACGGCACCTGGGAGTCTAAAGTGGCAAATATTCCATATCATGAGGGTGGCACTTTTACTGCATCAGCCATCCAAAAGCTTGTCAATTACCTCTTCACACCAAATGGAGGGACAAGGCCATCAGCAAAAAAAATCTTGGTTGTTATTACTGATGGAGAGTCACATGACAGAAATTTGTTGAAAGATGCAGCATCACAGGCAGAGAAAAACAGCATTGTCCGATTCGCAATTGGAGTTGGCAAAGCTTTTGATTATTACAACGCAAGAGAAGAGTTGAATACAATTGCTTCTGATCCAGACACTGACTATGTGTTTAAAGTGACAGACTTCAATGCACTgaaaaacattcttcaaaagtTGGAAGGGAACATTATTGCGATTGAAGGAACCCAGACTTCAGGAGATTCTTCCAGAATGGAGTTTGCTCAGGATGGATTCAGCACAGCTTTCACATCATCTGGAAGTGTGTTAGTGAGTGCTGTTGGAGCTTTCCAGTGGAAAGGTGGATACCGGGACAATTCCCAAGAAGGCTCCTTTCAAACAGGCAGTGAGCACGAAAGCTATCAAGGTTATTCGATGGCTGTTGCAACAGTGTCATTGACCAGCTTTGCTATTCTAGGAGCTCCAAGATACCAGCATAGAGGACAAGTCACTATTTCCAGAATCGGAACCAATGAAGTTCAACCTCTGGACTCTCCTATGCCTCAGATTGGCTCTTATTTTGGAGCTGAGGTGTGTGTGGTGGATTTGAACAGTGACTCTTATACAGATCTGCTTCTGGTATCAGCACCGACATACACAGAGTCTGAACGAGAGGGGAAAGTGTTTGTTTATAGTTTCACATCTTGGTCAAggttatttttttctgatgtggTGCTGGTGGGCATGGCCGGTCAGAGGGGTCGCTTTGGCTCTTCTCTAGCCAGTCCAGCAGATCTGAATGGTGATGGTTATAGGGATGTGCTGGTTGGTGCTCCATTAGAGGAGGAAGGACAGGGCAGCATCTACATCTTCAATGGACGAGATGGAGGGATCATTTCATCATACTCCCAGAGAATTGCTGGATCATCTGTAAAATCAGGATTGCAGTACTTTGGCGTTTCCTTGAGTCAATCCTCTCCAGACCAGACTGCAGACAGCCTTCCTGACATTGCTGCTGGGTCCAAAGGAGCAGTTCTGCTTCTCAGGTCCAGACCCATCATGCTCTTGGAAACAATGGTTTCTTACACCCCATCCAAAATATCAACCATTCAACAAGACTGCTTAATACCATTGCAGACCACTCTGACCGTGTGCTTCACCATGAAAGGATACAGGCATCACAGAAGAGGTTTGAATGCAAAAATTGCTTACAACATAACCCTGGATGCTAAAAGACAGGCCTATCGAGCATTCTTCTCAGCCAAAGAGCGTCTCCTCAGTGATGTGATTGACATTGGAAGTACAGAAGCTTGCAATAATCATAATTTCTCAATAGAGGCTTGTCCAGAAGATGCTCTGAATCCATTGTCCAATCAGTTAAAATTCACCTTTGAGGGTCTGCCATCTAGTCAAATGCAAAACCTGAGGCCAATACTGCTGCCAGAGATAAAGACCACCTCAGATCACGATGTAAGAGTTCATCTGTGTAAAGTTACGAGTGGAAATGATGCACTTTTAACAGTGGGCTATATAACAGTGGGTTTCACATATTACTAA
>TCONS_00008954
TGTCTCAGTCGGTCATGGCTTTTAACATCGATCCTGCCAGCTGGAAAACTTTCACTGGACCTTCACAGAGCCAAAATGTTGCCTTTGGCTACAAGGTGATACAGAAAGACACATCAAGTCTGATCGTGAGCGATCCTTTAATTCAAATCAACCAGGATAAAAGAGGACAAATTTATAACTGTGAGGTTGCAAAAGGAACCTGCACACAACTGAACATTACCGTGCCCTCAGAAGCTGTCAACATGTCTCTGGGATTCTCCATGGTTCAACATCCACAATCTTCAAAGCTGGCAATTTGTGGTCCTACCATTCCAAAGAATTGTACAACAGCTACCAACTACAGAGGCATGTGCTTTATTGGGAACAGTGGGGATTTTGGACCACCAATACCCAAATCCAAATACAGAGACTGTCTTGGTCAGATTGACATAGCTTTTCTACTGGATGGCTCTGGGAGTATAGGAATTTATGATTTTACAGTAATGAAGGGTTTTGTGACAAACGTGATCAGACGTTTTATTGAGCGGGATGCACAGTTTGCCATTGCACAGTACTCCAATGACTGTGATATTCACTACAATTTCAATGACCTCAAATTAGATGACGGCACCTGGGAGTCTAAAGTGGCAAATATTCCATATCATGAGGGTGGCACTTTTACTGCATCAGCCATCCAAAAGCTTGTCAATTACCTCTTCACACCAAATGGAGGGACAAGGCCATCAGCAAAAAAAATCTTGGTTGTTATTACTGATGGAGAGTCACATGACAGAAATTTGTTGAAAGATGCAGCATCACAGGCAGAGAAAAACAGCATTGTCCGATTCGCAATTGGAGTTGGCAAAGCTTTTGATTATTACAACGCAAGAGAAGAGTTGAATACAATTGCTTCTGATCCAGACACTGACTATGTGTTTAAAGTGACAGACTTCAATGCACTgaaaaacattcttcaaaagtTGGAAGGGAACATTATTGCGATTGAAGGAACCCAGACTTCAGGAGATTCTTCCAGAATGGAGTTTGCTCAGGATGGATTCAGCACAGCTTTCACATCATCTGGAAGTGTGTTAGTGAGTGCTGTTGGAGCTTTCCAGTGGAAAGGTGGATACCGGGACAATTCCCAAGAAGGCTCCTTTCAAACAGGCAGTGAGCACGAAAGCTATCAAGGTTATTCGATGGCTGTTGCAACAGTGTCATTGACCAGCTTTGCTATTCTAGGAGCTCCAAGATACCAGCATAGAGGACAAGTCACTATTTCCAGAATCGGAACCAATGAAGTTCAACCTCTGGACTCTCCTATGCCTCAGATTGGCTCTTATTTTGGAGCTGAGGTGTGTGTGGTGGATTTGAACAGTGACTCTTATACAGATCTGCTTCTGGTATCAGCACCGACATACACAGAGTCTGAACGAGAGGGGAAAGTGTTTGTTTATAGTTTCACATCTTGGTCAAggttatttttttctgatgtggTGCTGGTGGGCATGGCCGGTCAGAGGGGTCGCTTTGGCTCTTCTCTAGCCAGTCCAGCAGATCTGAATGGTGATGGTTATAGGGATGTGCTGGTTGGTGCTCCATTAGAGGAGGAAGGACAGGGCAGCATCTACATCTTCAATGGACGAGATGGAGGGATCATTTCATCATACTCCCAGAGAATTGCTGGATCATCTGTAAAATCAGGATTGCAGTACTTTGGCGTTTCCTTGAGTCAATCCTCTCCAGACCAGACTGCAGACAGCCTTCCTGACATTGCTGCTGGGTCCAAAGGAGCAGTTCTGCTTCTCAGGTCCAGACCCATCATGCTCTTGGAAACAATGGTTTCTTACACCCCATCCAAAATATCAACCATTCAACAAGACTGCTTAATACCATTGCAGACCACTCTGACCGTGTGCTTCACCATGAAAGGATACAGGCATCACAGAAGAGGTTTGAATGCAAAAATTGCTTACAACATAACCCTGGATGCTAAAAGACAGGCCTATCGAGCATTCTTCTCAGCCAAAGAGCGTCTCCTCAGTGATGTGATTGACATTGGAAGTACAGAAGCTTGCAATAATCATAATTTCTCAATAGAGGCTTGTCCAGAAGATGCTCTGAATCCATTGTCCAATCAGTTAAAATTCACCTTTGAGGGTCTGCCATCTAGTCAAATGCAAAACCTGAGGCCAATACTGCTGCCAGAGATAAAGACCACCTCAGATCACGAT

Function

symbol description
itgam Enables heat shock protein binding activity. Involved in ectodermal cell differentiation; positive regulation of neutrophil degranulation; and positive regulation of superoxide anion generation. Located in cell surface; extracellular space; and plasma membrane raft. Implicated in lupus nephritis.

GO:

id name namespace
GO:0007229 integrin-mediated signaling pathway biological_process
GO:0007155 cell adhesion biological_process
GO:0008305 integrin complex cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component

KEGG:

id description
ko04015 Rap1 signaling pathway
ko04514 Cell adhesion molecules
ko04145 Phagosome
ko04810 Regulation of actin cytoskeleton
ko04640 Hematopoietic cell lineage
ko04610 Complement and coagulation cascades
ko04613 Neutrophil extracellular trap formation
ko04670 Leukocyte transendothelial migration
ko05202 Transcriptional misregulation in cancer
ko05221 Acute myeloid leukemia
ko05133 Pertussis
ko05134 Legionellosis
ko05150 Staphylococcus aureus infection
ko05152 Tuberculosis
ko05146 Amoebiasis
ko05140 Leishmaniasis
ko04131 Membrane trafficking
ko04147 Exosome
ko04515 Cell adhesion molecules
ko04090 CD molecules
ko00536 Glycosaminoglycan binding proteins

ZFIN:

id description
ZDB-GENE-110510-4 Predicted to enable metal ion binding activity. Predicted to act upstream of or within cell adhesion and integrin-mediated signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of integrin complex. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (integrin subunit alpha M).

Ensembl:

ensembl_id ENSDARG00000096587

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00008953 False 2343 mRNA 0.43 18 4147714 4157240
TCONS_00008954 True 2213 mRNA 0.44 17 4149112 4157153

Neighbor

gene id symbol gene type direction distance location
XLOC_004473 si:dkey-32n7.4 coding upstream 2681 4114401 ~ 4145033 (+)
XLOC_004472 NA coding upstream 41304 4103788 ~ 4106410 (+)
XLOC_004471 NA coding upstream 54141 4092452 ~ 4093573 (+)
XLOC_004470 zgc:123217 coding upstream 103582 4036409 ~ 4044132 (+)
XLOC_004469 NA coding upstream 156291 3986079 ~ 3991423 (+)
XLOC_004475 itgam coding downstream 3564 4160804 ~ 4167750 (+)
XLOC_004476 mapk7 coding downstream 63113 4220353 ~ 4238827 (+)
XLOC_004477 mmp25b coding downstream 103539 4260779 ~ 4278329 (+)
XLOC_004478 NA coding downstream 251419 4408659 ~ 4450452 (+)
XLOC_004479 NA coding downstream 270883 4428123 ~ 4473148 (+)
XLOC_004456 NA non-coding upstream 1375324 2769565 ~ 2772390 (+)
XLOC_004450 NA non-coding upstream 1540682 2578020 ~ 2607032 (+)
XLOC_004480 CABZ01030103.1 non-coding downstream 340124 4497364 ~ 4497479 (+)
XLOC_004483 NA non-coding downstream 571777 4729017 ~ 4734988 (+)
XLOC_004484 NA non-coding downstream 591331 4748571 ~ 4751852 (+)

Expression


Co-expression Network