XLOC_006444 (HTRA2)


Basic Information

Item Value
gene id XLOC_006444
gene name HTRA2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007124.7
NCBI id CM002897.2
chromosome length 52186027
location 9074797 ~ 9091354 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00012487
aaaGCAACTGTTGTATTTATGAAAAGGTCAAGAATGAATCGACtctcacaatttatttaaatccacAGATTCATTCTCAAAAAATAACCCACTCTAGCCTAAATAAGGACCGAACCTATGTGAACGCTAACAGaatcctttACCAACGTTGCGTCTTGGCAAGTCATCTGATGTGCGTCAAGGTGAATTTGTGGTTGTCATGGGGAGCCCCTTTTCTCTTAAAAACACCATCACATCTGGAATCGTCAGCTCTGCTCAGAGAGGCAGTAAAGAACTGGGTCTTTCCAACTCCAACATGGACTACATCCAGACGGACGCTACCATAGATTTTGGAAATTCAGGAGGGCCTCTCATAAACCTGGATGGTGAGGTCATCGGCATTAATACCATGAAAGTGACAGCAGGTATTTCCTTCGCTATTCCCTCAGGCAGAGTCCGTCTCTTCCTAGACCGATCTGCAGACAAACAGAAGTCTTGGTTTGGAGAATCAGGATCGAAAAGGCGTTACATTGGAGTGATGATGTTGACTTTGACCCCCAGTATAATCAAAGAGCTAAGGATGCGAGACCTGTCCTTCCCTGATGTTTCTCATGGAGTTCTCATCCACCGTGTGATTGTAGGATCTCCAGCCAACAGaGCCGGAATGAAGCCAGGAGATGTTATTATTGAGATCAATGGGGTAAAGGTGAACACGTCGGAGGAGATATATAATGCTGTGAGGACCAGCGAAAGCTTAAATGTGGTCGTCCGCCGGGGGGCCGACCTGCTCATGCTGCACATGACCCCAGAGTCCACAGAGTGACATCAAGTCAAGTATTTAGTAAGATTAAGAAATGGTGAGTAATGAGAAGCTGTCATAGTTGGAGATGTTGTAAGAAAGGAATCATCTAAAGAGTTGAACAGTTTTAGCAAACGCTGGACATTCGTGTAGTAAACGTGTTTCTGGAAGCGTATGAAATAATGTGGATGATTCAGACTTCTGTACACTGgataaacctcagtgtgtctgcGCAAACTACACTATCAGTATTGATTTGAAGGAATATCACTGAATATTTTGTTTAGGATTGTCATGATGGCAACAAACACTCAAAGACCTTAATAAAACTGGGTGCTCTTATTGTGAAAAtgctgatgttttgtattgagtctcacattctcatgttacgacgtttgtattttaatacatttttctgaacAGCTCTGATTTCACAATAAACCATTGGAATATTTATGGA
>TCONS_00012486
aaaGCAACTGTTGTATTTATGAAAAGGTCAAGAATGAATCGACtctcacaatttatttaaatccacAGATTCATTCTCAAAAAATAACCCACTCTAGCCTAAATAAGGACCGAACCTATGTGAACGCTAACAGaatcctttACCAACGTTGCGTCTTGGCAAGTCATCTGATGTGCGTCAAGGTGAATTTGTGGTTGTCATGGGGAGCCCCTTTTCTCTTAAAAACACCATCACATCTGGAATCGTCAGCTCTGCTCAGAGAGGCAGTAAAGAACTGGGTCTTTCCAACTCCAACATGGACTACATCCAGACGGACGCTACCATAGATGATGGTGAGGTCATCGGCATTAATACCATGAAAGTGACAGCAGGTATTTCCTTCGCTATTCCCTCAGGCAGAGTCCGTCTCTTCCTAGACCGATCTGCAGACAAACAGAAGTCTTGGTTTGGAGAATCAGGATCGAAAAGGCGTTACATTGGAGTGATGATGTTGACTTTGACCCCCAGTATAATCAAAGAGCTAAGGATGCGAGACCTGTCCTTCCCTGATGTTTCTCATGGAGTTCTCATCCACCGTGTGATTGTAGGATCTCCAGCCAACAGaGCCGGAATGAAGCCAGGAGATGTTATTATTGAGATCAATGGGGTAAAGGTGAACACGTCGGAGGAGATATATAATGCTGTGAGGACCAGCGAAAGCTTAAATGTGGTCGTCCGCCGGGGGGCCGACCTGCTCATGCTGCACATGACCCCAGAGTCCACAGAGTGACATCAAGTCAAGTATTTAGTAAGATTAAGAAATGGTGAGTAATGAGAAGCTGTCATAGTTGGAGATGTTGTAAGAAAGGAATCATCTAAAGAGTTGAACAGTTTTAGCAAACGCTGGACATTCGTGTAGTAAACGTGTTTCTGGAAGCGTATGAAATAATGTGGATGATTCAGACTTCTGTACACTGgataaacctcagtgtgtctgcGCAAACTACACTATCAGTATTGATTTGAAGGAATATCACTGAATATTTTGTTTAGGATTGTCATGATGGCAACAAACACTCAAAGACCTTAATAAAACTGGGTGCTCTTATTGTGAAAAtgctgatgttttgtattgagtctcacattctcatgttacgacgtttgtattttaatacatttttctgaacAGCTCTGATTTCACAATAAACCATTGGAATATTTATGGA

Function

symbol description
htra2 Enables identical protein binding activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to interferon-beta; cellular response to retinoic acid; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in several cellular components, including chromatin; cytosol; and mitochondrial intermembrane space. Part of serine-type endopeptidase complex. Implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Biomarker of Alzheimer's disease; endometrial cancer; ovarian cancer; prostate cancer; and stomach cancer.

GO: NA

KEGG:

id description
ko04210 Apoptosis
ko04214 Apoptosis - fly
ko04215 Apoptosis - multiple species
ko05012 Parkinson disease
ko05022 Pathways of neurodegeneration - multiple diseases
ko01002 Peptidases and inhibitors
ko03110 Chaperones and folding catalysts

Ensembl:

ensembl_id ENSDARG00000092061

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00012487 False 1238 mRNA 0.42 7 9074797 9091354
TCONS_00012486 True 1205 mRNA 0.42 6 9074797 9091354

Neighbor

gene id symbol gene type direction distance location
XLOC_006443 si:dkey-112g5.11 coding downstream 28915 9020301 ~ 9045882 (-)
XLOC_006441 plekhh2 coding downstream 182283 8847421 ~ 8892514 (-)
XLOC_006440 si:ch73-105b23.1 coding downstream 245405 8825192 ~ 8829392 (-)
XLOC_006439 si:ch73-105b23.6 coding downstream 259267 8799168 ~ 8815530 (-)
XLOC_006438 calm2a coding downstream 289187 8777633 ~ 8785610 (-)
XLOC_006445 HTRA2 coding upstream 74507 9165861 ~ 9184178 (-)
XLOC_006446 si:dkey-33c12.11 coding upstream 96855 9188209 ~ 9213215 (-)
XLOC_006447 HTRA2 coding upstream 149571 9240925 ~ 9257731 (-)
XLOC_006448 HTRA2 coding upstream 170461 9261815 ~ 9284410 (-)
XLOC_006449 HTRA2 coding upstream 197029 9288383 ~ 9300299 (-)
XLOC_006338 rn7sk misc downstream 8248572 825904 ~ 826225 (-)
XLOC_006471 BX537274.2 misc upstream 1173387 10264741 ~ 10264905 (-)
XLOC_006437 NA non-coding downstream 298320 8760694 ~ 8776477 (-)
XLOC_006435 BX004962.2 non-coding downstream 419350 8655119 ~ 8655447 (-)
XLOC_006434 BX004962.1 non-coding downstream 424746 8649711 ~ 8650051 (-)
XLOC_006428 NA non-coding downstream 844632 8168713 ~ 8230165 (-)
XLOC_006426 NA non-coding downstream 1325596 7747111 ~ 7749201 (-)
XLOC_006458 NA non-coding upstream 410413 9501767 ~ 9558425 (-)
XLOC_006467 NA non-coding upstream 985861 10077215 ~ 10118935 (-)
XLOC_006468 NA non-coding upstream 1059565 10150919 ~ 10232078 (-)
XLOC_006469 NA non-coding upstream 1158820 10250174 ~ 10253034 (-)
XLOC_006472 NA non-coding upstream 1183932 10275286 ~ 10346890 (-)

Expression


Co-expression Network