CI01000299_05428160_05443433 (APP, APPA)


Basic Information

Item Value
gene id CI01000299_05428160_05443433
gene name APP, APPA
gene type misc
species grasscarp (Ctenopharyngodon idella)
category of species economic fish

Chromosome Information

Item Value
chromosome id CI01000299
NCBI id null
chromosome length 6567443
location 5427661 ~ 5443433 (-)
genome version v1_2015/06_NatureGenetics_grasscarp_Genome

Sequence

>CI01000299_05428160_05443433.mRNA
ATGTTTAGACTGACGTTCTGCCGTTATATCAGGCCAATCCTGGTGTTTTGGCTTCATCCTAATCCACCTCCTGTACTGAACCTGTCCTTCACCGGTGGTGGGAACGGACTTTGTTGCTTGTCAGGCCTTTTATATGTGCCGTCAGACTCCGGTACCGGACTGCTGGCCGAGCCGCAGGTCGCCATGTTCTGCGGGAAACTCAACATGCACATCAACGTTCAGACCGGAAAATGGGAACCCGATCCATCTGGAACCAAGAGCTGCATCGGAACAAAAGAGGGAATCCTGCAGTACTGCCAGGAGGTGTATCCAGAGCTTCAGATCACGAATGTGGTGGAGGCCAATCAGCCCGTCAGTATCTGGGACTGGTGCAAGAAGGGCCGCAAGCAGTGCCGCAGTCACATGCACATCGTGGTGCCCTACCGCTGCCTGGTGGGTGAGTTCGTGAGCGACGCTCTGCTGGTTCCTGACAAGTGTAAGTTCCTGCACCAGGAGCGCATGGACATGTGTGAGAGTCACCTGCACTGGCACACCGTCGCCAAAGAGTCTTGCGGTGACCGTAGCATGAATCTCCATGACTACGGGATGCTGTTGCCGTGTGGTATCGACCGTTTCCGTGGCGTTGAGTTCGTCTGCTGCCCTGCGGAAGCGGAGAAGGAGTCGGACAGCGCTGCCGTGGAGGAGGATGATTCTGATGTGTGGTGGGGAGGAGCGGAGGCCGACTACAGCGAGAACAGAGGTGTGTTTTGCAAGCGCAGAGACGGGCCCCTGCAGGGCCATGTTGCCCCGCTGTCGTTTATGTCAATGACTTCACTACAAACCTTAAAGCTTCCTCGCTTCTCTCTTCATGACTTTATCTGTCAAATGCTGTTTAGACTTTACCCTCCGGACGCAGTGGACCGATACCTGGAGACGCCAGCGGACGAGAACGAACACACTCATTTCCTGAAGGCCAAAGAGAGTCTGGAGGCCAAACACCGCGAGCGCATGTCTCAGGTGATGAGGGAATGGGAAGAGGCCGAGAGACAGGCGAAGAGTTTACCGCGCAATGACAAGAAGGCCGTGATCCAGCACTTCCAGGAGAAGGTGGAGGCGCTGGAGCAGGAGGCGGCCAGCGAGCGTCAGCAGCTGGTGGAGACGCACATGGCTCGTGTGGAGGCGTTGCTGAATGACCGCCGGCGTCTGGCCCTCGAGAGCTACCTGTCTGCCCTGCAGGCCGATCCGCCCCGGCCGCGGCATGTGTTCAGCCTGCTGAAGAAGTACGTGCGCGCTGAGCAGAAGGACCGGCAGCACACGCTCAAACACTTCGAACACGTGCGCATGGTCGACCCCAAGAAGGCTGCGCAGATTCGGCCGCAGGTGCTGACCCATCTGCGTGTGATCGAGGAGCGGATGAATCAGTCTCTCGGGCTGCTGTACAAGGTGCCGGGAGTCGCTGATGATATCCAGGACCAAGTCGAGCTGTTGCAGCGCGAGCAGCAGGAGATGTCAGCTCAGCTGGCGAACCTGCAGAGCGACGTGCGGGTCAGTTACGGTAACGACGCCCTGATGCCCGACAGCACCGCCAGCCTGGACCTGCTGCCCGCTGAAGACACGCAGGGCTTCGGCTTCATTCACCCCGAGAGCTTCAACCAGCCCAACACACAGAACGAGGTTGAGCTGGTCGATGCCCGACCTGTCGCAGACCGAGGCCTCCCGACCCGACCAGTGTCTGGACTGAAGCCTGACGATGTTCCTGAGCTGCGGATGGAAGCCGAAGAGAGACACAGCGAAGTTTACCACCAGAAACTGGTTTTCTTTGCGGAGGATGTGAGCTCCAATAAAGGAGCTATTATTGGCCTGATGGTCGGAGGAGTTGTCATAGCAACCATCATCGTCATCACCCTGGTGATGCTGAGGAAGAAGCAGTACACGTCCATCCACCACGGAATCATTGAGGTGGACGCTGCCGTGACCCCGGAGGAACGTCACCTGTCCAAGATGCAGCAGAACGGCTATGAAAACCCCACCTACAAGTTCTTCGAGCAGATCCACAACTGATGGCGTAACGCCTCCCCCCTCACCCTCACCCTCCCCGTACCCTCATCTCCAGACGCTGCAGAAGACACCAGCCGAATCTCACCGCGTCATAAACATCACGTCTGTTATTGGCCAGTTTCTGTGACTGTCAATCAAAGACGACCTCCCACTGGCTGGATGAACATTCACATGATCAGATTAGTTCTGTTGGGGTCAGTTTCAGGTTGTTGAAGATTCTGTTTCAGATTGAATGCACAATTCAAATCACAAATCAAATTGAATGCATAATTCAGTTTCAATTGGAATTCAAATCACAAATCAGATTGAACACAATTCAAGTTCAATTAAAATAAATTTGAATGCATAATTTGAATTCAGTTCACATCAAATGAACGTAATTCAAATTAATTTCAAATCAAAATGAACGCATAATTTCAAATTCATTTCAAATTAATTTGAACACAATTCAAATTCATTTCATATCAAATTAAACGCATAATTCGAATTCATTTCAAATAAA

Function

symbol description
appa Predicted to enable heparin binding activity; serine-type endopeptidase inhibitor activity; and transition metal ion binding activity. Acts upstream of or within central nervous system development; convergent extension; and vasculature development. Predicted to be located in Golgi-associated vesicle and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including axis; nervous system; pleuroperitoneal region; segmental plate; and solid lens vesicle. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein).
app Enables several functions, including PTB domain binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in several processes, including defense response to other organism; modulation of chemical synaptic transmission; and positive regulation of macromolecule metabolic process. Acts upstream of or within regulation of gene expression. Located in several cellular components, including cytoplasmic vesicle; dendrite; and nuclear envelope lumen. Part of several cellular components, including amyloid-beta complex; high-density lipoprotein particle; and intermediate-density lipoprotein particle. Colocalizes with several cellular components, including cell body; low-density lipoprotein particle; and very-low-density lipoprotein particle. Implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Biomarker of Alzheimer's disease; obesity; and periodontitis.

GO:

id name namespace
GO:0007399 nervous system development biological_process

KEGG:

id description
K04520 APP; amyloid beta A4 protein

RNA

RNA id representative length rna type GC content exon number start site end site
CI01000299_05428160_05443433.mRNA False 2539 mRNA 0.53 17 5427661 5443433

Neighbor

gene id symbol gene type direction distance location
CI01000299_05419449_05423414 ATP5J coding downstream 4247 5419403 ~ 5423414 (-)
CI01000299_05379545_05381902 NA coding downstream 45521 5379149 ~ 5382140 (-)
CI01000299_04913779_04927715 NA coding downstream 499946 4913373 ~ 4927715 (-)
CI01000299_04861862_04862244 NA coding downstream 565068 4861577 ~ 4862593 (-)
CI01000299_04741460_04746667 NA coding downstream 680994 4741447 ~ 4746667 (-)
CI01000299_05457285_05462908 NA coding upstream 13674 5456864 ~ 5463491 (-)
CI01000299_05466693_05471714 ADAMTS1 coding upstream 22209 5465642 ~ 5471987 (-)
CI01000299_05478688_05502027 ADAMTS5 coding upstream 34049 5477482 ~ 5503268 (-)
CI01000299_05512316_05521322 NA coding upstream 68618 5512051 ~ 5521322 (-)
CI01000299_05602070_05604608 NA coding upstream 158550 5601983 ~ 5604615 (-)
G407669 NA non-coding downstream 9290 5413334 ~ 5418371 (-)
G407591 NA non-coding downstream 245299 5085394 ~ 5182362 (-)
G407565 NA non-coding downstream 430752 4957987 ~ 4996909 (-)
G407564 NA non-coding downstream 471296 4956098 ~ 4956365 (-)
G407562 NA non-coding downstream 487722 4939691 ~ 4939939 (-)
G407734 NA non-coding upstream 109195 5552628 ~ 5554845 (-)
G407764 NA non-coding upstream 191407 5634840 ~ 5639866 (-)
G407848 NA non-coding upstream 330816 5774249 ~ 5775541 (-)
CI01000299_05896205_05898855 NA non-coding upstream 378142 5896043 ~ 5898857 (-)
G407413 NA other downstream 876940 4475994 ~ 4550721 (-)
G405053 NA other downstream 3409611 2017687 ~ 2018050 (-)
G404976 NA other downstream 3546673 1855639 ~ 1880988 (-)
G407805 NA other upstream 384403 5835889 ~ 5835989 (-)
CI01000299_06526127_06532048 CEP97 other upstream 1088568 6526127 ~ 6532048 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
bowfin (Amia calva) AMCG00014102 app coding CM030128.1 CM030128.1 1858678 ~ 1869442 (+)