XLOC_012697 (ctsd)


Basic Information

Item Value
gene id XLOC_012697
gene name ctsd
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007129.7
NCBI id CM002902.2
chromosome length 51023478
location 16133595 ~ 16146081 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00025357
TGCGCACTGCGCAGAATGCAGCGCAGCCTTGACGCTCGTCAACGCGCCGTCACATGACTGTGAGCAAAAGTTGCTCGGCAGCAGCACATTGTGTCAGCTGACTGTGGCTGTTTGTCCTACATATTAGACCGCACAACAATAACATCCCCACAGCGATACTGCTCTCATTATCGTTAACTGGTCCTGAGGGCTCGCCAACATGAGAATCGCCTTTTTGCTGCTCGTTGTTGCCTTTTTCTGCACGTCCGACGCGATTGTCCGGATACCACTAAAGAAGTTTCGAACCCTCAGACGAACACTAAGTGACTCTGGCAGATCATTAGAGGAGCTTGTGTCTAGTTCTAATTCCCTGAAATACAACCTGGGCTTCCCAGCTAGTAATGATCCTACTCCAGAAACACTCAAAAACTACCTAGATGCTCAGTATTATGGCGAGATCGGTCTTGGCACTCCTGTCCAGACCTTCACTGTGGTGTTTGACACTGGATCCTCCAACCTGTGGGTACCTTCAGTCCACTGTTCCCTGACTGACATCGCCTGCTTGCTTCATCACAAGTACAATGGGGGCAAATCAAGCACCTATGTGAAGAATGGGACTCAATTTGCCATCCAGTATGGATCAGGAAGTTTGTCCGGGTATCTCAGCCAGGACACCTGCACGATTGGAGATATTGCAGTTGAAAAGCAGATATTTGGAGAAGCTATCAAGCAGCCAGGAGTGGCCTTCATTGCTGCCAAGTTTGACGGTATTCTCGGGATGGCCTATCCTCGCATCGCTGTCGATGGGGTTCCTCCTGTTTTCGACATGATGATGAGCCAGAAGAAAGTGGAGAAAAATGTTTTCTCTTTCTATCTTAACAGAAACCCTGACACTCAGCCTGGTGGTGAGCTGCTACTGGGAGGAACAGACCCCAAATATTACACTGGAGATTTCAACTATGTGGACATCAGCAGACAGGCCTATTGGCAGATTCACATGGATGGcATGAGCATCGGCAGTGGACTATCTCTGTGTAAAGGAGGATGTGAAGCCATTGTGGACACTGGGACGTCTCTGATCACTGGCCCAGCTGCTGAAGTCAAAGCCCTGCAGAAGGCTATTGGAGCCATCCCTCTGATGCAGGGAGAGTACATGGTAGACTGTAAGAAAGTGCCGACGCTCCCCACCATCTCCTTCTCCCTGGGTGGAAAGGTCTACTCGCTGACTGGAGAACAGTACATACTCAAGGAAAGCCAGGGTGGACACGACATCTGCCTGAGTGGATTCATGGGTCTGGATATCCCACCGCCTGCCGGACCGCTGTGGATTCTGGGTGATGTTTTCATTGGCCAGTACTACACTGTGTTTGACAGGGAGAATAACAGAGTGGGCTTCGCTAAGGCCAAATCAGTCTAACATTTAACACTTGAGACCTCAGTGTCATGAGAGTAAGGAGAAAAGTAGGACATCTGTCAATATCGTCTCTGCGTCAGTGACGGAGTTTAGCATTATGATGATCCATGTCTTTGCACTGCTGTTAGCTTTTAAAAGTTTTCGTTTTAAAGAGGCACATGGAGAAGAAATGATTCAGGGAAAAGTCAAACCGATGACAAGTTACACTCATTTGCTTTTTAGTTCAGGCTTGTTTGAATATCTGTGATTGCAATGCaaggttttaacatttttatttgaaaattgtCATGTCCTTGATTTTTACACACTACCtgttttaagatttttattgTGGAATGACTTCTAATGACTGATCAAATCAAAACGGGGAATAAAGCTGTTATAAACTCAA
>TCONS_00025358
TGTGTCAGCTGACTGTGGCTGTTTGTCCTACATATTAGACCGCACAACAATAACATCCCCACAGCGATACTGCTCTCATTATCGTTAACTGGTCCTGAGGGCTCGCCAACATGAGAATCGCCTTTTTGCTGCTCGTTGTTGCCTTTTTCTGCACGTCCGACGCGATTGTCCGGATACCACTAAAGAAGTTTCGAACCCTCAGACGAACACTAAGTGACTCTGGCAGATCATTAGAGGAGCTTGTGTCTAGTTCTAATTCCCTGAAATACAACCTGGGCTTCCCAGCTAGTAATGATCCTACTCCAGAAACACTCAAAAACTACCTAGATGCTCAGTATTATGGCGAGATCGGTCTTGGCACTCCTGTCCAGACCTTCACTGTGGTGTTTGACACTGGATCCTCCAACCTGTGGGTACCTTCAGTCCACTGTTCCCTGACTGACATCGCCTGCTTCTGTACATGCGTCATCTGCTTAACAGTTTTCAGAGTGGGATTTACCAACATTGGAGTGCAAAATGAAGATGCGCTGTCCTTCGGCTTGCCTTAGAAAATGTGCTTCATCACAAGTACAATGGGGGCAAATCAAGCACCTATGTGAAGAATGGGACTCAATTTGCCATCCAGTATGGATCAGGAAGTTTGTCCGGGTATCTCAGCCAGGACACCTGCACGATTGGAGATATTGCAGTTGAAAAGCAGATATTTGGAGAAGCTATCAAGCAGCCAGGAGTGGCCTTCATTGCTGCCAAGTTTGACGGTATTCTCGGGATGGCCTATCCTCGCATCGCTGTCGATGGG
>TCONS_00025359
GTCCTACATATTAGACCGCACAACAATAACATCCCCACAGCGATACTGCTCTCATTATCGTTAACTGGTCCTGAGGGCTCGCCAACATGAGAATCGCCTTTTTGCTGCTCGTTGTTGCCTTTTTCTGCACGTCCGACGCGATTGTCCGGATACCACTAAAGAAGTTTCGAACCCTCAGACGAACACTAAGTGACTCTGGCAGATCATTAGAGGAGCTTGTGTCTAGTTCTAATTCCCTGAAATACAACCTGGGCTTCCCAGCTAGTAATGATCCTACTCCAGAAACACTCAAAAACTACCTAGATGCTCAGTATTATGGCGAGATCGGTCTTGGCACTCCTGTCCAGACCTTCACTGTGGTGTTTGACACTGGATCCTCCAACCTGTGGGTACCTTCAGTCCACTGTTCCCTGACTGACATCGCCTGCTGTAAGTCCACACAGAGCCTGCCAGCTTTTTGCACAGTGCACTGTCAGGTCACTGATGTCTTTACATTATTCATTTAAAGTGAATTCTTTCAGAAACAAGAAGTTACTTTAGTTTGGCACAGTGTTGCTCAAGTTTGTCGgtggcaacttttttttttcatggttgCAAGTATGTTTCTGTAATCTTGTCATAGATCATATCAACTT

Function

symbol description
ctsd Predicted to enable aspartic-type endopeptidase activity. Acts upstream of or within muscle structure development; response to bacterium; and retinal pigment epithelium development. Predicted to be active in lysosome. Is expressed in several structures, including eye; liver; muscle; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (cathepsin D).

GO:

id name namespace
GO:0003406 retinal pigment epithelium development biological_process
GO:0009617 response to bacterium biological_process
GO:0006508 proteolysis biological_process
GO:0061061 muscle structure development biological_process
GO:0005764 lysosome cellular_component
GO:0004190 aspartic-type endopeptidase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0008233 peptidase activity molecular_function

KEGG:

id description
ko04071 Sphingolipid signaling pathway
ko04142 Lysosome
ko04140 Autophagy - animal
ko04210 Apoptosis
ko04915 Estrogen signaling pathway
ko05152 Tuberculosis
ko05415 Diabetic cardiomyopathy
ko01002 Peptidases and inhibitors
ko04147 Exosome

ZFIN:

id description
ZDB-GENE-010131-8 Predicted to enable aspartic-type endopeptidase activity. Acts upstream of or within muscle structure development; response to bacterium; and retinal pigment epithelium development. Predicted to be active in lysosome. Is expressed in several structures, including eye; liver; muscle; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (cathepsin D).

Ensembl:

ensembl_id ENSDARG00000057698

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00025357 False 1784 mRNA 0.47 9 16133595 16146081
TCONS_00025358 False 799 nonsense_mediated_decay 0.48 6 16133684 16140348
TCONS_00025359 True 635 lncRNA 0.45 3 16133708 16138355

Neighbor

gene id symbol gene type direction distance location
XLOC_012696 bhlhe41 coding upstream 3430 16125852 ~ 16130165 (+)
XLOC_012695 FO834850.1 coding upstream 33370 16053455 ~ 16100225 (+)
XLOC_012694 itpr2 coding upstream 91091 15937610 ~ 16042504 (+)
XLOC_012693 eea1 coding upstream 251664 15841449 ~ 15881931 (+)
XLOC_012692 nudt4a coding upstream 296253 15795566 ~ 15837342 (+)
XLOC_012698 lrriq1 coding downstream 46002 16192083 ~ 16218370 (+)
XLOC_012699 alx1 coding downstream 100725 16246806 ~ 16254746 (+)
XLOC_012700 NA coding downstream 164040 16310121 ~ 16315811 (+)
XLOC_012701 nts coding downstream 183944 16330025 ~ 16339902 (+)
XLOC_012702 eps8b coding downstream 280185 16426266 ~ 16442814 (+)
XLOC_012689 CR536616.1 non-coding upstream 421050 15712429 ~ 15712545 (+)
XLOC_012684 NA non-coding upstream 676848 15453915 ~ 15456747 (+)
XLOC_012683 NA non-coding upstream 680943 15449505 ~ 15452652 (+)
XLOC_012682 NA non-coding upstream 684150 15446623 ~ 15449445 (+)
XLOC_012681 NA non-coding upstream 692123 15433464 ~ 15441472 (+)
XLOC_012704 NA non-coding downstream 575718 16721799 ~ 16721982 (+)
XLOC_012707 NA non-coding downstream 652674 16798755 ~ 16862419 (+)
XLOC_012709 NA non-coding downstream 795381 16941462 ~ 16941847 (+)
XLOC_012711 CR925798.1 non-coding downstream 832547 16978628 ~ 16983066 (+)

Expression


Co-expression Network