| Item | Value |
|---|---|
| gene id | XLOC_012694 |
| gene name | itpr2 |
| gene type | coding |
| species | zebrafish (Danio rerio) |
| category of species | model fish |
| Item | Value |
|---|---|
| chromosome id | NC_007129.7 |
| NCBI id | CM002902.2 |
| chromosome length | 51023478 |
| location | 15937610 ~ 16042504 (+) |
| genome version | GRCz11_2017_zebrafish_Genome |
| symbol | description |
|---|---|
| itpr2 | Predicted to enable several functions, including calcium ion binding activity; inositol 1,4,5 trisphosphate binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Predicted to be involved in release of sequestered calcium ion into cytosol. Predicted to act upstream of or within calcium ion transmembrane transport. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum; plasma membrane; and secretory granule membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and isolated anhidrosis with normal sweat glands. Orthologous to human ITPR2 (inositol 1,4,5-trisphosphate receptor type 2). |
| id | name | namespace |
|---|---|---|
| GO:0051209 | release of sequestered calcium ion into cytosol | biological_process |
| GO:0070588 | calcium ion transmembrane transport | biological_process |
| GO:0006816 | calcium ion transport | biological_process |
| GO:0030667 | secretory granule membrane | cellular_component |
| GO:0005783 | endoplasmic reticulum | cellular_component |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component |
| GO:0016529 | sarcoplasmic reticulum | cellular_component |
| GO:0005886 | plasma membrane | cellular_component |
| GO:0016020 | membrane | cellular_component |
| GO:0030659 | cytoplasmic vesicle membrane | cellular_component |
| GO:0005509 | calcium ion binding | molecular_function |
| GO:0035091 | phosphatidylinositol binding | molecular_function |
| GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | molecular_function |
| GO:0005262 | calcium channel activity | molecular_function |
| GO:0070679 | inositol 1,4,5 trisphosphate binding | molecular_function |
| id | description |
|---|---|
| ko04371 | Apelin signaling pathway |
| ko04020 | Calcium signaling pathway |
| ko04070 | Phosphatidylinositol signaling system |
| ko04022 | cGMP-PKG signaling pathway |
| ko04114 | Oocyte meiosis |
| ko04210 | Apoptosis |
| ko04218 | Cellular senescence |
| ko04540 | Gap junction |
| ko04611 | Platelet activation |
| ko04621 | NOD-like receptor signaling pathway |
| ko04625 | C-type lectin receptor signaling pathway |
| ko04922 | Glucagon signaling pathway |
| ko04929 | GnRH secretion |
| ko04912 | GnRH signaling pathway |
| ko04915 | Estrogen signaling pathway |
| ko04921 | Oxytocin signaling pathway |
| ko04935 | Growth hormone synthesis, secretion and action |
| ko04918 | Thyroid hormone synthesis |
| ko04928 | Parathyroid hormone synthesis, secretion and action |
| ko04924 | Renin secretion |
| ko04925 | Aldosterone synthesis and secretion |
| ko04927 | Cortisol synthesis and secretion |
| ko04270 | Vascular smooth muscle contraction |
| ko04970 | Salivary secretion |
| ko04971 | Gastric acid secretion |
| ko04972 | Pancreatic secretion |
| ko04724 | Glutamatergic synapse |
| ko04725 | Cholinergic synapse |
| ko04728 | Dopaminergic synapse |
| ko04726 | Serotonergic synapse |
| ko04720 | Long-term potentiation |
| ko04730 | Long-term depression |
| ko04723 | Retrograde endocannabinoid signaling |
| ko04750 | Inflammatory mediator regulation of TRP channels |
| ko05205 | Proteoglycans in cancer |
| ko05170 | Human immunodeficiency virus 1 infection |
| ko05163 | Human cytomegalovirus infection |
| ko05167 | Kaposi sarcoma-associated herpesvirus infection |
| ko05131 | Shigellosis |
| ko05010 | Alzheimer disease |
| ko05012 | Parkinson disease |
| ko05017 | Spinocerebellar ataxia |
| ko05020 | Prion disease |
| ko05022 | Pathways of neurodegeneration - multiple diseases |
| ko04934 | Cushing syndrome |
| ko04040 | Ion channels |
| id | description |
|---|---|
| ZDB-GENE-050419-192 | Predicted to enable several functions, including calcium ion binding activity; inositol 1,4,5 trisphosphate binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Predicted to be involved in release of sequestered calcium ion into cytosol. Predicted to act upstream of or within calcium ion transmembrane transport. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum; plasma membrane; and secretory granule membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and isolated anhidrosis with normal sweat glands. Orthologous to human ITPR2 (inositol 1,4,5-trisphosphate receptor type 2). |
| ensembl_id | ENSDARG00000011909 |
| RNA id | representative | length | rna type | GC content | exon number | start site | end site |
|---|---|---|---|---|---|---|---|
| TCONS_00025352 | False | 5841 | mRNA | 0.49 | 42 | 15937610 | 16042414 |
| TCONS_00025353 | True | 6027 | mRNA | 0.49 | 42 | 15937610 | 16042504 |
| gene id | symbol | gene type | direction | distance | location |
|---|---|---|---|---|---|
| XLOC_012693 | eea1 | coding | upstream | 55679 | 15841449 ~ 15881931 (+) |
| XLOC_012692 | nudt4a | coding | upstream | 100268 | 15795566 ~ 15837342 (+) |
| XLOC_012691 | ube2na | coding | upstream | 144447 | 15778110 ~ 15793163 (+) |
| XLOC_012690 | si:ch211-219a15.4 | coding | upstream | 169274 | 15758375 ~ 15768336 (+) |
| XLOC_012688 | si:ch211-264e16.1 | coding | upstream | 218679 | 15706160 ~ 15718931 (+) |
| XLOC_012695 | FO834850.1 | coding | downstream | 10951 | 16053455 ~ 16100225 (+) |
| XLOC_012696 | bhlhe41 | coding | downstream | 83348 | 16125852 ~ 16130165 (+) |
| XLOC_012697 | ctsd | coding | downstream | 91091 | 16133595 ~ 16146081 (+) |
| XLOC_012698 | lrriq1 | coding | downstream | 149579 | 16192083 ~ 16218370 (+) |
| XLOC_012699 | alx1 | coding | downstream | 204302 | 16246806 ~ 16254746 (+) |
| XLOC_012689 | CR536616.1 | non-coding | upstream | 225065 | 15712429 ~ 15712545 (+) |
| XLOC_012684 | NA | non-coding | upstream | 480863 | 15453915 ~ 15456747 (+) |
| XLOC_012683 | NA | non-coding | upstream | 484958 | 15449505 ~ 15452652 (+) |
| XLOC_012682 | NA | non-coding | upstream | 488165 | 15446623 ~ 15449445 (+) |
| XLOC_012681 | NA | non-coding | upstream | 496138 | 15433464 ~ 15441472 (+) |
| XLOC_012700 | NA | non-coding | downstream | 267617 | 16310121 ~ 16315811 (+) |
| XLOC_012704 | NA | non-coding | downstream | 679295 | 16721799 ~ 16721982 (+) |
| XLOC_012707 | NA | non-coding | downstream | 756251 | 16798755 ~ 16862419 (+) |
| XLOC_012709 | NA | non-coding | downstream | 898958 | 16941462 ~ 16941847 (+) |
| XLOC_012711 | CR925798.1 | non-coding | downstream | 936124 | 16978628 ~ 16983066 (+) |
| species | gene id | symbol | gene type | chromosome | NCBI id | location |
|---|---|---|---|---|---|---|
| bowfin (Amia calva) | AMCG00012748 | itpr2,LOC100196824 | misc | CM030125.1 | CM030125.1 | 6476249 ~ 6517983 (+) |