XLOC_030468 (npr2)


Basic Information

Item Value
gene id XLOC_030468
gene name npr2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007116.7
NCBI id CM002889.2
chromosome length 72500376
location 54580962 ~ 54661956 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00059529
ttagcccacacaattcacctgtaccacatgtttttggactgtggggcaaaccagaCAGAAAAAGGCAATATTACTGTCGCGGTGATGCTGCCCGAAAACCTGAAGTATTCTTGGGCATCGCCGCGCGTCCTCCCCGCTATCCGTATGGCGCAAGAGAAAATTCAGAAAAGCGGACTTTTAAGGGGACACACAATCAACCTTCTTAACTTTAGCACAGAGGATTCCTCAGGTTCTTGTTCGGAAAACGAGGCGCAAATTATCGCTGTGGACACAAAACTTTACCACAAACCAGATGCGTTCATCGGACCCGGCTGCACGTATTCGGTGGCGTCGGTCGGACGGTTCGCGTCCCACTGGAAACTCCCTTTGATAACCGCGGGAGGACCAGCGTATGGTTTTGATAAGTGGGAAGAGTTTAAAACTATTGTCAGGACGGGCCCGACCACCAAGAAACTCGGAGATTTTGTCAATTATCTGCACGGACAGTTTAACTGGAGCTCTCGCGCGTTAATGATCTTTCATGACCTCAAACAGGACGACCGGCCGCATTACTTTCTCTCCGAGGGCATTTACACGGTTCTGCGCGAGGAAAACATTACAGTGTTGGCTTTCCCTTATGAAGACGAACAAACTTATAATTATAAAGATATGATCACATTTATAAAGGACAACGGCAGAAttgtgtatatatgcgGCCCTCTACCGACGTTCTTCCAAATAATGAAGCTCTTTGAGGATGAAGTGAAGAGCCCAGAGGACTACGCCATCTTTTACCTTGACGTGTTTGCAGAGAGTTTAAGTGGTGATGTTCCAATGCCCTGGCAGGGTTCAGATATCCAGTGGAATGACCCCATCAAGCTATTTCAGTCTGTGTTCGTTGTAACATACCAGGAGCCAGACAGCCCTGAGTATACCGCTTTCCGCAAAGAACTCCACAAAAGAGCAATACAAGACTTTAATGTACAATTGGAACCCTCGATGATGGATTTTATTGCTGGCTGTTTCCATGATGGTTTTGTGCTATATGCAAAAGCCCTCAGTGAAGCGTTAGCAGACGGCGTGTCTCAGAACGATGGAATCAACATAACTGCGAGAATGCAAAACCGCAGGCTCTGGGGGGTGACGGGCCTTGTAAGCATAGATCAGAAAAATGCCAGATTCACGGACTTTAGCCTTTGGGCAATGACAAACCTGAAAAGTGGGCAATACGCAATTGTTGGTCACTACAATGGGACCAGTAAAGAAATCTTGTGGTCCCCAACAGAGAAGATTCAATGGCCAAAGGGTTGCCCACCTCTGGACTACCCACCCTGTGGATTCTCTCCGTGCAAGGAAGATCATCTTCCTGTTCTTGGAATAGTGGCTGTTGGGTCTGGTCTGGCCCTCATCATATTCGGAATTTCCAGTTTTCTAATCTACAGGAAACTGAAGCTGGAAAAAGAGTTAGCTGGGATGCTTTGGAGGATACGGTGGGAGGAACTCCAGTTTGAAAGTCCCAACAAATATCACAAGCGTGCAGGAAGCCGCCTCACTCTTTCTCAGAGAGGTTCCAGCTATGGCTCCTTGATAACAGCTCATGGAAAATATCAGCTATTTGCAAAAACAGGCTATTTTAAGggCAACCTGGTGGCCATCAAGCATGTGAACAAGAAGAGGATTGAGCTCACCAGACAAGTGTTGTTTGAATTGAAGCATATGAGAGATGTGCAGTTCAACCATTTGACAAGGTTTATTGGCGCTTGCATCGATCCACCAAACATCTGCATTGTGACAGAATATTGCCCCCGGGGAAGTCTACAGGACATCCTTGAAAATGAGAGCATCAACCTGGACTGGATGTTCCGATACTCACTGATCAATGACATTGTGAAGGGAATGAATTATCTACACAACAGTTACATTGGCTCCCATGGCAATCTGAAATCATCTAATTGTGTGGTGGATAGCCGCTTCGTTTTGAAAATCACAGATTATGGTCTGGCAAGCTTCCGTTCGTCTTGTGAAAATGAAGACTCACATGCGCTGTATGCAAaaaagctTTGGACAGCTCCAGAGTTGCTGATATATGATAGGCATCCACCCCAAGGGACCCAGAAAGGAGATGTGTACAGTTTTGGGATAATACTACAAGAGATAGCACTCCGGAACGGGCCGTTTTATGTTGAAGGAATGGATCTTAGTCCCAAAGagataaTTCAGAAGGTGCGGAATGGCCAGAAACCATACTTTAGGCCCACTACAGACAACAGCCGGCACTGTGAAGAGCTGACCATCTTAATGGAAGGCTGTTGGTCTGAAGATCCTGCAGAAAGACCCGACTTCAGCCATATTAAGGTCTTCATTGCAAAATTTAACAAGCAGCACCAGTATTCTCAATACTTGTTGTCCAGAATGGAACAGTATGCCAATAACCTGGAGAACTTGGTAGAGGAGCGAACACAAGCCTACCTCGAGGAAAAACGAAAAGCTGAAAATCTTCTTTACCAAATCCTTCCACATTCAGTGGCGGAGCAGCTCAAGCGAGGGGAGACCGTACAAGCAGAAGCATTTGACAGCGTCACCATCTATTTCAGTGACATAGTGGGCTTCACGTCAATGTCTGCTGAAAGTACGCCATTACAGGTGGTGACATTGCTGAATGATCTTTACACATGCTTTGATGCCATCATTGATAATTTTGATGTATATAAGGTGGAAACAATCGGTGATGCGTACATGGTGGTCTCAGGTCTGCCTGTGCGGAATGGGAAGCTACATGCACGTGAGATCGCCGGCATGTCACTGGCTTTACTGGAGCAGGTTAAAACCTTCAAAATCAGACAcagaccaaatgatcaactacgaCTGCGGATAGGAATTCACACAGGTACCATTATCattATTTCAAAATTTCTGATGAACTGTTTGTTTGTGATGGTCGTTTTCTCAACAGCTCTGAGGATACACATGTCCTCAGCAACCAAAGAGGTTCTGGATGAGTTTGGTTATTTCGAACTCCAGCTGCGAGGAGATGTGGAGATGAAGGGTAAAGGCAAAATGAGAACATATTGGCTTCTGGGAGAGAAGACAGATGTCTATGTTATCTGA
>TCONS_00059530
ATTGCTTTACCTGGAATGGGATCGCTACTTAAGATGGGATATCGTGTTTTTATTGTGCTGCTTACACGCATGGTCGTACTGGAATGCAGAGCAGAAAAAGGCAATATTACTGTCGCGGTGATGCTGCCCGAAAACCTGAAGTATTCTTGGGCATCGCCGCGCGTCCTCCCCGCTATCCGTATGGCGCAAGAGAAAATTCAGAAAAGCGGACTTTTAAGGGGACACACAATCAACCTTCTTAACTTTAGCACAGAGGATTCCTCAGGTTCTTGTTCGGAAAACGAGGCGCAAATTATCGCTGTGGACACAAAACTTTACCACAAACCAGATGCGTTCATCGGACCCGGCTGCACGTATTCGGTGGCGTCGGTCGGACGGTTCGCGTCCCACTGGAAACTCCCTTTGATAACCGCGGGAGGACCAGCGTATGGTTTTGATAAGTGGGAAGAGTTTAAAACTATTGTCAGGACGGGCCCGACCACCAAGAAACTCGGAGATTTTGTCAATTATCTGCACGGACAGTTTAACTGGAGCTCTCGCGCGTTAATGATCTTTCATGACCTCAAACAGGACGACCGGCCGCATTACTTTCTCTCCGAGGGCATTTACACGGTTCTGCGCGAGGAAAACATTACAGTGTTGGCTTTCCCTTATGAAGACGAACAAACTTATAATTATAAAGATATGATCACATTTATAAAGGACAACGGCAGAAttgtgtatatatgcgGCCCTCTACCGACGTTCTTCCAAATAATGAAGCTCTTTGAGGATGAAGTGAAGAGCCCAGAGGACTACGCCATCTTTTACCTTGACGTGTTTGCAGAGAGTTTAAGTGGTGATGTTCCAATGCCCTGGCAGGGTTCAGATATCCAGTGGAATGACCCCATCAAGCTATTTCAGTCTGTGTTCGTTGTAACATACCAGGAGCCAGACAGCCCTGAGTATACCGCTTTCCGCAAAGAACTCCACAAAAGAGCAATACAAGACTTTAATGTACAATTGGAACCCTCGATGATGGATTTTATTGCTGGCTGTTTCCATGATGGTTTTGTGCTATATGCAAAAGCCCTCAGTGAAGCGTTAGCAGACGGCGTGTCTCAGAACGATGGAATCAACATAACTGCGAGAATGCAAAACCGCAGGCTCTGGGGGGTGACGGGCCTTGTAAGCATAGATCAGAAAAATGCCAGATTCACGGACTTTAGCCTTTGGGCAATGACAAACCTGAAAAGTGGGCAATACGCAATTGTTGGTCACTACAATGGGACCAGTAAAGAAATCTTGTGGTCCCCAACAGAGAAGATTCAATGGCCAAAGGGTTGCCCACCTCTGGACTACCCACCCTGTGGATTCTCTCCGTGCAAGGAAGATCATCTTCCTGTTCTTGGAATAGTGGCTGTTGGGTCTGGTCTGGCCCTCATCATATTCGGAATTTCCAGTTTTCTAATCTACAGGAAACTGAAGCTGGAAAAAGAGTTAGCTGGGATGCTTTGGAGGATACGGTGGGAGGAACTCCAGTTTGAAAGTCCCAACAAATATCACAAGCGTGCAGGAAGCCGCCTCACTCTTTCTCAGAGAGGTTCCAGCTATGGCTCCTTGATAACAGCTCATGGAAAATATCAGCTATTTGCAAAAACAGGCTATTTTAAGggCAACCTGGTGGCCATCAAGCATGTGAACAAGAAGAGGATTGAGCTCACCAGACAAGTGTTGTTTGAATTGAAGCATATGAGAGATGTGCAGTTCAACCATTTGACAAGGTTTATTGGCGCTTGCATCGATCCACCAAACATCTGCATTGTGACAGAATATTGCCCCCGGGGAAGTCTACAGGACATCCTTGAAAATGAGAGCATCAACCTGGACTGGATGTTCCGATACTCACTGATCAATGACATTGTGAAGGGAATGAATTATCTACACAACAGTTACATTGGCTCCCATGGCAATCTGAAATCATCTAATTGTGTGGTGGATAGCCGCTTCGTTTTGAAAATCACAGATTATGGTCTGGCAAGCTTCCGTTCGTCTTGTGAAAATGAAGACTCACATGCGCTGTATGCAAaaaagctTTGGACAGCTCCAGAGTTGCTGATATATGATAGGCATCCACCCCAAGGGACCCAGAAAGGAGATGTGTACAGTTTTGGGATAATACTACAAGAGATAGCACTCCGGAACGGGCCGTTTTATGTTGAAGGAATGGATCTTAGTCCCAAAGagataaTTCAGAAGGTGCGGAATGGCCAGAAACCATACTTTAGGCCCACTACAGACAACAGCCGGCACTGTGAAGAGCTGACCATCTTAATGGAAGGCTGTTGGTCTGAAGATCCTGCAGAAAGACCCGACTTCAGCCATATTAAGGTCTTCATTGCAAAATTTAACAAGCAGCACCAGTATTCTCAATACTTGTTGTCCAGAATGGAACAGTATGCCAATAACCTGGAGAACTTGGTAGAGGAGCGAACACAAGCCTACCTCGAGGAAAAACGAAAAGCTGAAAATCTTCTTTACCAAATCCTTCCACATTCAGTGGCGGAGCAGCTCAAGCGAGGGGAGACCGTACAAGCAGAAGCATTTGACAGCGTCACCATCTATTTCAGTGACATAGTGGGCTTCACGTCAATGTCTGCTGAAAGTACGCCATTACAGGTGGTGACATTGCTGAATGATCTTTACACATGCTTTGATGCCATCATTGATAATTTTGATGTATATAAGGTGGAAACAATCGGTGATGCGTACATGGTGGTCTCAGGTCTGCCTGTGCGGAATGGGAAGCTACATGCACGTGAGATCGCCGGCATGTCACTGGCTTTACTGGAGCAGGTTAAAACCTTCAAAATCAGACAcagaccaaatgatcaactacgaCTGCGGATAGGAATTCACACAGGGCCTGTATGTGCCGGTGTAGTGGGTCTGAAGATGCCCCGATACTGTTTATTCGGAGATACCGTCAACACAGCATCCCGTATGGAGTCTACAGGTGAAGCTCTGAGGATACACATGTCCTCAGCAACCAAAGAGGTTCTGGATGAGTTTGGTTATTTCGAACTCCAGCTGCGAGGAGATGTGGAGATGAAGGGTAAAGGCAAAATGAGAACATATTGGCTTCTGGGAGAGAAGACAGATGTCTATGTTATCTGA

Function

symbol description
npr2 Predicted to enable guanylate cyclase activity; protein kinase activity; and purine ribonucleoside triphosphate binding activity. Acts upstream of or within cardiac muscle cell proliferation. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including fin; head; kidney; neural tube; and oocyte. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2).

GO:

id name namespace
GO:0035556 intracellular signal transduction biological_process
GO:0006468 protein phosphorylation biological_process
GO:0006182 cGMP biosynthetic process biological_process
GO:0009190 cyclic nucleotide biosynthetic process biological_process
GO:0060038 cardiac muscle cell proliferation biological_process
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0005524 ATP binding molecular_function
GO:0016829 lyase activity molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0016849 phosphorus-oxygen lyase activity molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0004383 guanylate cyclase activity molecular_function

KEGG:

id description
ko00230 Purine metabolism
ko04022 cGMP-PKG signaling pathway
ko04921 Oxytocin signaling pathway
ko04270 Vascular smooth muscle contraction
ko01001 Protein kinases

ZFIN:

id description
ZDB-GENE-141030-2 Predicted to enable guanylate cyclase activity; protein kinase activity; and purine ribonucleoside triphosphate binding activity. Acts upstream of or within cardiac muscle cell proliferation. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including fin; head; kidney; neural tube; and oocyte. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2).

Ensembl:

ensembl_id ENSDARG00000104393

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00059529 False 3087 mRNA 0.46 22 54580962 54661956
TCONS_00059530 True 3156 mRNA 0.46 23 54585431 54661956

Neighbor

gene id symbol gene type direction distance location
XLOC_030467 anapc2 coding upstream 398 54555567 ~ 54580564 (+)
XLOC_030466 tprn coding upstream 38900 54501105 ~ 54542062 (+)
XLOC_030465 tmem203 coding upstream 81845 54497475 ~ 54499117 (+)
XLOC_030464 NA coding upstream 98095 54481759 ~ 54482867 (+)
XLOC_030463 traf2b coding upstream 127114 54422941 ~ 54453848 (+)
XLOC_030469 pmchl coding downstream 23219 54685175 ~ 54685710 (+)
XLOC_030470 NA coding downstream 49067 54711023 ~ 54711655 (+)
XLOC_030471 cd180 coding downstream 276678 54938634 ~ 54941004 (+)
XLOC_030472 NA coding downstream 403826 55065782 ~ 55074200 (+)
XLOC_030473 CU207241.1 coding downstream 457554 55119510 ~ 55123220 (+)
XLOC_030460 CR450749.2 non-coding upstream 472448 54106010 ~ 54108514 (+)
XLOC_030455 NA non-coding upstream 1388157 53191662 ~ 53192805 (+)
XLOC_030454 NA non-coding upstream 1389895 53188004 ~ 53191067 (+)
XLOC_030449 BX957336.2 non-coding upstream 2138470 52438392 ~ 52442492 (+)
XLOC_030474 NA non-coding downstream 472649 55134605 ~ 55140137 (+)
XLOC_030475 NA non-coding downstream 484677 55146633 ~ 55154249 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000059_00396907_00442561 NPR2 coding CI01000059 null 396184 ~ 443478 (+)