XLOC_003785 (slc11a2)


Basic Information

Item Value
gene id XLOC_003785
gene name slc11a2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007122.7
NCBI id CM002895.2
chromosome length 45484837
location 281833 ~ 287670 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00007292
gAGTCAGCAGTGTAatgaaacaggaagtcctcaCACTGATCTTTTCCCAGCAAACAACGAGACCCTGGAGGTGGACATCTACAAAGGGGGTGTGGTTCTGGGCTGTTTCTTCGGGCCGGCTGCGCTCTACATCTGGGCTGTGGGGATCCTGGCTGCGGGGCAGAGCTCCACCATGACTGGCACATACTCTGGGCAGTTTGTGATGGAGggTTTCCTGAACCTGCGCTGGTCCCGCTTCGCCCGTGTGCTGCTGACGCGCTCCATCGCCATCTTCCCCACCCTGCTGGTGGCCGTGTTTCAGGACGTGCAGCATCTCACCGGCATGAACGACTTCCTCAACGTGCTGCAGAGcatgcagctgCCGTTCGCTCTGATCCCCATCCTCACCTTCACCAGTCTGACGTCTCTCATGCACGACTTCGCTAACGGACTcgtgTGGAAGATCGGCGGGGGTCTGCTCATCCTGCTGGTGTGTGCGATCAACATGTATTTTGTGATTGTGTACGTGACGGATCTGAACAGCACCGTCCTCTACGTGCTGGCGGCGCTGCTGTCCATCGCTTACCTCAGCTTCGTCATATACCTGGTGTGGCAGTGTCTGCTGGCTCTCGGTGTGTCCGCTCTGGCCTGTGGATCTTCAGCTGAGTTTCCAGCAGCCGCTCTCATACAGGAGCAGCCCGAGTTCGACTCCTGAACCAAAGACTGAAGCAGGAGCTGggtttctgcacacacacacacacacacacacacacacacacacagtgcagcaGATGATCATTAACAGTAGTGTGATATATCTAATAGACTAACAGCTGATGAGCAGCGCTGATGATTCAACCGTTATTTAAAGCTCCTTTAGTTTATGTTATAGTGTTTTAATGAGCCGCAGGAGCAGTATCCTGCGTTTATACCCTGAACATGTGTTTTACCTGCAGTAAATACTGACTTGCAGAGCAGCGAAGGATTTATTTGAGCTGAAACGACGCCATTATTCATACTTGAACACAGTGAAGCACCCAACCCCGGCTGAGGAGGATCATTGCGGCCTGATTCACAGTCAGTTGTGCTCAGATCTGCTCCATTATTTCATGCACAGGTTCATTTCAgagactgctgctgctgctgctgctgctataCGGTCATGCTTCAGAACAATGCTTCTCTTATGGTCCAGCCAATGGAGGAAGCAGAAGAATCCTAATCTAATCTGAAGACCTGTTTATTCTGCTTGTTTAAGGAGAAACTGGTTTATTTGGGCTCATTGTTTCTGTTGTGCTTGTCTGGTGAATGCTGCTTGCTTTAAGAGTTTGTAGATCTGTGGACTAGACTCAAGACAGCAGTAAGAGAGGTGTTGCTCTGCAGCGCAGTGTTTGCTGTAGTTTAATCCGGCAGGTTAATAATCACCTTTAATGATTGAGAGATAATCAGCCATCAAGTGCCTTTGTGGAGATCTGCGTGTGTCGTGTCGCGCGTCTTCAGTGTTCTGTTTCTCCTGAACGCCACCTTGACCTGAGCTTCAGAGCAGATTTATGAGTTCTGTTTGCTGTTGCCGTTGTTTTAAACACATTCCTGACTGTCAGACATGCAgaagtgtgtgtttgagtctgtTCTGCagtggatgatgatgatgatgatgatgcaataATAAACGTCCACCGCCACA

Function

symbol description
slc11a2 Enables iron ion transmembrane transporter activity. Acts upstream of or within several processes, including embryonic hemopoiesis; hemoglobin biosynthetic process; and response to copper ion. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alar plate midbrain region; digestive system; lens; solid lens vesicle; and ventral mesoderm. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2).

GO:

id name namespace
GO:0042541 hemoglobin biosynthetic process biological_process
GO:0030001 metal ion transport biological_process
GO:0046688 response to copper ion biological_process
GO:0035162 embryonic hemopoiesis biological_process
GO:0010038 response to metal ion biological_process
GO:0010039 response to iron ion biological_process
GO:0005886 plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0046873 metal ion transmembrane transporter activity molecular_function
GO:0015086 cadmium ion transmembrane transporter activity molecular_function
GO:0005381 iron ion transmembrane transporter activity molecular_function
GO:0005384 manganese ion transmembrane transporter activity molecular_function

KEGG:

id description
ko04142 Lysosome
ko04216 Ferroptosis
ko04978 Mineral absorption
ko05010 Alzheimer disease
ko05012 Parkinson disease
ko02000 Transporters

ZFIN:

id description
ZDB-GENE-021115-1 Enables iron ion transmembrane transporter activity. Acts upstream of or within several processes, including embryonic hemopoiesis; hemoglobin biosynthetic process; and response to copper ion. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alar plate midbrain region; digestive system; lens; solid lens vesicle; and ventral mesoderm. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2).

Ensembl:

ensembl_id ENSDARG00000024295

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00007292 True 1663 mRNA 0.50 6 281833 287670

Neighbor

gene id symbol gene type direction distance location
XLOC_003784 npffl coding downstream 2505 276057 ~ 279328 (-)
XLOC_003783 alas1 coding downstream 11623 260763 ~ 270210 (-)
XLOC_003782 dusp7 coding downstream 45067 220544 ~ 236766 (-)
XLOC_003781 NA coding downstream 87118 193460 ~ 194715 (-)
XLOC_003780 CU633745.1 coding downstream 91372 183570 ~ 190461 (-)
XLOC_003786 poc1a coding upstream 18337 306007 ~ 309420 (-)
XLOC_003787 CR855375.2 coding upstream 61443 349113 ~ 351701 (-)
XLOC_003788 NA coding upstream 81457 369127 ~ 369686 (-)
XLOC_003789 CR855375.5 coding upstream 106823 394493 ~ 396724 (-)
XLOC_003790 znf831 coding upstream 123200 410870 ~ 426525 (-)
XLOC_003938 BX324177.10 misc upstream 11051134 11338804 ~ 11339100 (-)
XLOC_003942 BX324177.17 misc upstream 11079924 11367594 ~ 11367890 (-)
XLOC_003943 BX324177.3 misc upstream 11082785 11370455 ~ 11370653 (-)
XLOC_003944 BX324177.4 misc upstream 11093234 11380904 ~ 11381204 (-)
XLOC_003945 BX324177.6 misc upstream 11096163 11383833 ~ 11384130 (-)
XLOC_003776 NA non-coding downstream 152667 128158 ~ 129166 (-)
XLOC_003773 CABZ01072245.1 non-coding downstream 210293 61190 ~ 71540 (-)
XLOC_003793 CR855375.4 non-coding upstream 172145 459815 ~ 459930 (-)
XLOC_003797 CU695207.2 non-coding upstream 257791 545461 ~ 548398 (-)
XLOC_003799 CABZ01069324.1 non-coding upstream 311770 599440 ~ 601308 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000057_04657451_04663499 NRAMP-BETA, SLC11A2, NRAMP-ALPHA coding CI01000057 null 4657262 ~ 4663499 (-)
bowfin (Amia calva) AMCG00008840 NA coding CM030126.1 CM030126.1 13074080 ~ 13097915 (+)