LOC103034175 (tgfbr1,tgfbr1b,LOC108441711,LOC107757190,LOC105890151,LOC106590284)


Basic Information

Item Value
gene id LOC103034175
gene name tgfbr1,tgfbr1b,LOC108441711,LOC107757190,LOC105890151,LOC106590284
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035906.1
NCBI id CM008309.1
chromosome length 35377769
location 7429999 ~ 7514588 (-)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007233388.3
cacacgcctagctagctagctggagAGAagttgtatgtgtatgtgtgtgtgtgtgtgagtgtgcgcgtgtgtgtgacAAGCAGGCAGTGTAGAATAAGTCTGATCCGAGGATGGATGCAATACCGCGCTGTCTGCTGTTTCTGGTCCTGCTGTTCGGGACGCGGATCGGCGGGTCTGAAGCCTTACAATGTTACTGTCACCGCTGCCCCAACTCCACCTGCACCACGAACGGCCTGTGCTACGTGTCCATAACCAAGTCTGGGAGTGTGACGAAGCAGGAGAGCTTTTGCCTCACTGAGGATGAACTGATCCCACCCGATCGCCCCTTCGTCTGCGCCCCGTCCACCAAGGACGACTCGGGCATCTACCCCATGTGCTGCAACTTGGACTGGTGCAACAAGAACCCCGACCCCAGCATATTTCCAGtgccaACAACGAAGACTCCCTCTCTGGGTCCAGTCGCTCTGGCGGCCGTGATCGCCGGACCCGTTTGTGTGCTCTGCTTCGTGTTGGTCACTATCTTCTACATCTGCCACAGCCGCTCGGTCATACACCACCGTGTGCCTAATGAAGAGGACCCCTCCATGGACCACCCCTTCATCACAGTGGGAACCACACTCAAAGACCTCATCTACGACATGACCACGTCTGGATCGGGTTCTGgTCTTCCCTTGCTGGTGCAGAGGACCATTGCCAGAACCATCATCCTGCAGGAGAGCATTGGAAAGGGCCGGTTCGGGGAGGTGTGGCGGGGGAAGTGGAGAGGAGAAGAAGTAGCAGTGAAGATCTTCTCCTCTCGTGAGGAGCGCTCCTGGTTCCGCGAGGCCGAGATCTACCAGACAGTCATGCTCCGCCACGAGAACATCCTGGGATTCATCGCCGCCGACAACAAAGATAATGGAACCTGGACCCAGCTGTGGCTGGTGTCGGACTACCATGAGCACGGCTCCCTGTTTGATTACCTGAACAGGTACACAGTGACGGTGGAGGGCATGATCAAGCTGTCTCTGTCCACCGCCAGCGGCCTGGCCCACCTGCACATGGAGATCGTAGGAACACAAGGCAAGCCGGCTATCGCTCACAGGGATCTGAAATCCAAGAACATCTTAGTGAAGAAGAACGGAACTTGCTGCATCGCAGACCTCGGCTTGGCTGTGCGCCATGACTCGGCCACAGACACTATTGACATCGCCCCCAACCACCGAGTGGGCACCAAAAGGTATATGGCCCCAGAGGTACTTGATGATTCAATAAATATGAAGCATTTCGAGTCCTTCAAGAGAGCAGACATCTACGCCATGGGCTTGGTCTTCTGGGAAATCGCAAGCAGATGCTCTATTGGAGGCATTCACGAAGACTACCAGCTGCCGTATTATGACCTGGTGCAGTCAGATCCATCAGTGGAGGAAATGAGGAAGGTGGTGTGTGAGCAGAAATTACGACCCAACATTCCTAACAGGTGGCAGAGCTGTGAGGCTCTGCGGGTGATGGCTAAGATCATGAGGGAGTGCTGGTACGCTAACGGGGCGGCCCGCCTCACCGCCCTGCGGATCAAGAAGACCCTGTCCCAGCTCAGCCAGCAGGAGGGCATTAAAATGTAGGCCGGAGAGCCGGAGGAGGCACTCACCTTAGCGtcttattgatttttttttttttttttttttttttgtcctttttctatttttttttttttcttttttttttttttttaaatatctttattatAAAGGTCATCggtattgttgttattataatcCGTGGTTATTGCATTACAGCTCTATGTCCTCCAAGATGGAGTTGGAGACGTAGAGAGAGGACTTTGAGCACTATGAATGAAGGTTtgtttggactttttttttcttttcttttttttctttttaaactctGGCTTTGACTGAGACTGAGCTTGCCGCTGAAACCTCACTCTGGACTTGTGAGACTGAAGAAACTGAAggactcttctttttttttggagccTCACGTCTAGACGAGCATGCCGCGGTAAACCCGCGCCCGTTTTCGGTTGGATCTCTTTTGCCTCTCTCCTCATCTGTCCCGGAACTGGCTGagatgttttatatattggAGAGAAGCGGCAGACGCTGTTAGACAGTGATTTAGGACTTTTGTGCAGGTCGTAACTCGCGGAGGCACCGTCGTGAATTAAATATTCATGCCAGTGTTTTCGGCTGTGGCTTCTGCTGCCGGTCAGGGCTGGGTTCACTGAGGATCCGCTGAGAGATGGAGTgatttcctcctcctcctcctcctccactacCTTCTCCTCCTGAGTTTGGTCATTCAGTGGTCAGGTagatgttatatatgtatattgtatttctTTCAGTTTGCACCTTTTgtgttttctcctcctctcctagtcactgtttattttttataattaagtttttattaagtttttattaagggttttttttctttttttttttcgttttttcggcCAACAAACTGGACATGACCTCATTCAGTCTTGGCAAACATGCTGCGACATATGCAATATAGATAAATCCTATCTATTTTCTATCGTAAAACATTCTGCTACTACTACAACAGTTCAACAGCTTCGATGACAACCACGCCCTCCAAGCCAGGTGTTACCGGAAAGTGCCACTGCTTTAAACCGACCATCCCTCATCATGTGGATCGGTCCCTTCACTTGGCTGTCCGTTGAAACGTTGTAATGTAAGGACGACGCTCGCAGAAGGACAGAGAAGGGTCCGCCACAGAGTTTCTGCCTCTCTTATGCACACGTAGCGGACGCCGGCGGGGGCCGTCGCACACAAAACAACTTGCTGGTGCCATTTTTCTTCCATTAATACAGTACATCACCAACATCATGATCATCATCATAATTGTTGTCATTgttgtcatcatcatcatagtcTAATTCTACGATGCAGCATTGAGGGACGTACTTTTCAGGTCATCCTCAGTAATGTAGACCACCGACCCTTGTCTCTTACGGGCGTGGTGAATGCACATTGGGGATTGGCCGAGCGCCACGTCATCCGCCTGCCCGTCCTCTACAGAGCAGTCgtacagttttctttttcttttttttccccttacgatttttctaaaagaggATGCTGCTGCAGGACCTGACCTGGCCATGCCGGCTCATTCCCTCACCACCCCCTCAAAACGCAGACTGTTCTGTTCCCACCTGAAACAGTTTGTTAAGCGTATTATGATGGACAGTTACTACAGGATGAGTAAACCAAGCTACTCTCACAGACTCTCACAACAAACTGTCGCTTTATGCggaagacttaaaaaaaaaaaaaaaaaaactatgaaaactATTCAAAAATGAGCGCTCTGGTGCGCTCATTCGGATGTTTGGAGTCGAACACATCAGCATTACTCAAGTTGCCCTGTAAAGAAATGTATTTCTCGCGTTTTCATGTATTTCTCTTTTGTCTTACGTCcgtcttttgtttgttttcagtgtttcagCAAAGATGGTGGGGTACATTCTTTTTGAttctttgaaatatatatatatagcaaacaGGTTACATTACTAAGCCATAGATCTTCCAACATTTTATGGCAACTTGTTGTGTAGAatgtaaaaaggaaaaaaaaaacacacacacaaatcctgTTGACTGCTCCAAACCTCCAATGAGCAAGCAAGCCTTAAGGGACCAATAGAATTGGGGtcgatttgtaaaaaaaaaaaaaaaaaaaaaaattggtgatTGATATTTACAGGGAAGGACTGAAATGTAGCACCAGATCTAGcatttcttttctatttctgtGGAAGGAATACTTTATTGCCACACAAATGAGCCTGCACTCTGAGACGCAAACCTGAAGCATGAAATTCATGAATATTGCTTAATGCAAACATGTGCATATTGGGATGAAATTATTGACTTAATGAGAGAATTGACTGTGGAATACCAGCCTTTTTTAGTTACTGAAGATACAGTGCTGGTTAAAGGATGGTATTagacaggacaagacaagatTAACCTCatcaatttgttttattaattagtcTAAACTCAATTTTCTTTTAGTTTGGTTCAGTTCGGTTTGGTTTGGCAGTTTATGGTGAATCGTAAGTAAAGAAAGTCCACTGACCAAGATGGCTTCTGCATAAGCATGCATGTTCACTGTAGGTAGATTTCCTAATATGTCATGTAATAATGCACAAGCCCTTCAAACCTTCAACCAAACATTAAGCTAAACAacgaaagaagaaaagaagcacGGTTATTAATTCAGCAATAACAACGAAACGTGTTCATGTTTATTGGTGTGGCAATAGGGTGTTAATCTGTCTCGCATCTTTCCAGTGCTCACATACtcatggattgatggattgtaTCCTAAAACAACCTGCGAGACCTCTGTCTATGTGTGCTCAGCTTGTTCCGTTATCAGGCTTCAAAACAAGCATTTGATGAACTGCAGTGTGCTTACAGAGTGAAACCCCATTCCTGAACACTCTTCTTCATTCCATGGTCCTTCTCGACCTGCACGGGCTAACCTTTCATCTTTCTTTTCATGTGTCAAATTCAGATTCTGCTCATAATTAAGCTTGGAAGCTTTCGTCAGGTGCCGTACCTGGTGGTGTTTTGTCTGTTACTCTGCTCTGCCTTACACTCTTACAAATGAAGGTGCTCCAAATGGTTCTGGTGTGAGAGATGCTGTAGAAGAACCATATTTTTCTTAAGTTCTTAAGAACCAATGTGCCCAGTTTTTGCTAAGAGTATGATATTCACCAATTCAACCATAAGAAACTGTTCTTTGGGCAGATATTTATACTCTTTTGGTTCCCAAATTTGGTCTGACCAAAGTTGGAATTCAATTTAACTATAGATGAGGCtctaagtggtccagcagatAGCCGTTTTAATTCATGCTGcttcgccatcagcagccagagtcagagagagcacaattggcacaATTGCTCTTTCTAGGATAGTAGATGGTGAGGGAaggtgctctctcccctcatcactcctggTGTGGTCGGTATAGGTGACTGTTAGTTGATGTGTCATCTTCCTCCTCGTAGTGTTGGGAGCATTACTCATGACTAGtgatgagtgtgttgggtaacTCGCAATccaaattaataattaacaatagCGGAGGATTAATTACCGATGTTCTGATAAAATTCGAATCCAATGCAATAGCTTGTGCaactataaaaaaa

Function

symbol description
tgfbr1b Predicted to enable SMAD binding activity; activin binding activity; and transmembrane receptor protein serine/threonine kinase activity. Predicted to be involved in several processes, including heart development; protein phosphorylation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within phosphorylation and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in endoderm; heart; nervous system; pharyngeal arch; and somite. Human ortholog(s) of this gene implicated in Ferguson-Smith tumor; Loeys-Dietz syndrome 1; Lynch syndrome; and urinary bladder cancer. Orthologous to human TGFBR1 (transforming growth factor beta receptor 1).
tgfbr1 Enables several functions, including ATP binding activity; I-SMAD binding activity; and transforming growth factor beta receptor activity, type I. Contributes to transforming growth factor beta binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and protein phosphorylation. Located in several cellular components, including bicellular tight junction; endosome; and membrane raft. Part of receptor complex. Implicated in Ferguson-Smith tumor; Loeys-Dietz syndrome 1; Lynch syndrome; and urinary bladder cancer.

NR:

description
PREDICTED: TGF-beta receptor type-1-like

GO:

id name namespace
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway biological_process
GO:0035556 intracellular signal transduction biological_process
GO:0023014 signal transduction by protein phosphorylation biological_process
GO:0006468 protein phosphorylation biological_process
GO:0016020 membrane cellular_component
GO:0005524 ATP binding molecular_function
GO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity molecular_function
GO:0005024 transforming growth factor beta-activated receptor activity molecular_function

KEGG:

id description
K04674 TGFBR1, ALK5; TGF-beta receptor type-1

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007233388.3 True 5206 mRNA 0.45 9 7429999 7514588

Neighbor

gene id symbol gene type direction distance location
lancl2 lancl2 coding downstream 31416 7336728 ~ 7398583 (-)
LOC103026452 NA coding downstream 328540 7099238 ~ 7101459 (-)
LOC103045308 LOC108431216,LOC108271758 coding downstream 1022977 6277116 ~ 6407022 (-)
stk17a stk17a coding downstream 1154689 6227605 ~ 6275310 (-)
impa2 impa2 coding downstream 1204399 6211898 ~ 6225600 (-)
LOC103025816 NA coding upstream 21390 7535978 ~ 7550381 (-)
reck reck,LOC108441710,LOC106590283,LOC106579676,LOC107655684 coding upstream 42894 7557482 ~ 7636308 (-)
LOC103025511 LOC108441709,LOC108271601 coding upstream 128468 7643056 ~ 7698012 (-)
kynu kynu,LOC107558516 coding upstream 191414 7706002 ~ 7735457 (-)
boll NA coding upstream 232286 7746874 ~ 7760984 (-)
G88833 NA non-coding downstream 14514 7415058 ~ 7415485 (-)
G88824 NA non-coding downstream 47902 7325465 ~ 7382097 (-)
G88781 NA non-coding downstream 252385 7175374 ~ 7177614 (-)
G88780 NA non-coding downstream 281030 7131763 ~ 7148969 (-)
G88749 NA non-coding downstream 389408 7040248 ~ 7040591 (-)
G88923 NA non-coding upstream 84214 7598802 ~ 7642778 (-)
G89035 NA non-coding upstream 554816 8069404 ~ 8069620 (-)
G89029 NA non-coding upstream 561296 8075884 ~ 8079057 (-)
G89036 NA non-coding upstream 564476 8079064 ~ 8079780 (-)
G89038 NA non-coding upstream 566785 8081373 ~ 8081590 (-)
G88789 NA other downstream 187429 7241711 ~ 7242570 (-)
LOC103026131 LOC108431006 other downstream 214760 7103571 ~ 7215239 (-)
G88779 NA other downstream 311873 7117661 ~ 7118126 (-)
vstm2a vstm2a other downstream 697335 6676275 ~ 6732664 (-)
G88465 NA other downstream 2834674 4595058 ~ 4595325 (-)
LOC103029706 LOC108429024,LOC108268385,LOC107749226,LOC107685514 other upstream 2270035 9784623 ~ 9854099 (-)
G89690 zyx,LOC108428910 other upstream 2380237 9894825 ~ 9901700 (-)
G89708 gapdh,LOC107550818 other upstream 2446694 9961282 ~ 9964606 (-)
LOC103025178 LOC108429038 other upstream 2497229 10011817 ~ 10042853 (-)
G89751 NA other upstream 2708932 10223520 ~ 10224663 (-)

Expression


Co-expression Network