XLOC_015969 (LPL)


Basic Information

Item Value
gene id XLOC_015969
gene name LPL
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007113.7
NCBI id CM002886.2
chromosome length 59640629
location 55365727 ~ 55390332 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00031643
TATAAAAGCCGTGAACAGCTGCAGGTTCACAATGATAAATAACACGCGGAGCTTCCGTTGAAATCATTCGCTTAACATCATTGCTTAACACTGCTTTGCTCTAttaaaattattgatttattgtgtAACTTACTATGGGACAGGAAAATTTCTGGCTGCTGCTAATGGGATTTTCTCTAATTGCGAGCGAACCAATTTTCAACTCCACTGAAGAAGCGTTTGCAAGTAATTTTACAGATTACAGTGACATTGAGTCTAAGTTCTCCATCAGAAGTGTTGAATTTCCAGACGAGGATCTTTGCTATCTTGTCCCGGGACAACAGGACTCCATTTCAGACTGTAACTTCAAAAATGATTCACAAACCTTCCTTATTATCCACGGATGGTCGGTTGCGGGTCTGTTTGAGAGCTGGGTTTATAAGCTGGTGACGGCTCTGTATGATCGTGAACCCAGCGCTAATGTCATTGTTGTGGACTGGCTGGATCGGGCCAACAAACACTACCCCAAATCAGCAGAAAACACCAGGCTAGTGGGGGCCGACGTTGCCAAGTTTGTCAACTGGCTGGAGGAGTTGGATTATCCGCTGGAGAAAGTGCATCTTTTAGGCTACAGTCTCGGTGCGCATGTCGCAGGAGTCGCAGGAAACCTCACCAACAACAAAGTCCACAGAATTACAGGTCTGGATCCGGCGGGCCCCAGTTTTGAGAATGCAGACATTCTGCGGCGTCTGTCTCCTGACGATGCCTCGTTTGTGGACGTTTTGCACACAAACACCAGAGGCTCTCCCGACCTCAGCATCGGCATCCAGAGACCTGTGGGGCACGTGGACATTTACCCCAATGGAGGAACTTTCCAGCCTGGCTGCAGCATTCAGCACACAATGAAGCTCATCGCCACATGCGGCATATACAATATGGACCAGATCGTGAAATGTTCTCACGAGCGCTCCATCCACCTGTTCATCGACTCTCTTGTGAATCAGGCGTATCAGAGCTGGGCGTTTCGCTGCGCCTCCAGAGACTCCTTTAATAAAGGCCTGTGTCTGAGCTGCAGGAAAAACCGCTGCAACACACTGGGATACAACGTCAAGAAGATCCGCAGCACCAGAAGCACCAAGATGTACCTCAAAACCCGCGAGATGATGCCCTTTAAAGTGTTTCATTACCAGATTAAAATGCATATGTTTAGTGATAAAAACATGACTTTGCTGGAGCAGCCGATGAAAGTGTCTCTATTCGGGACAATCGATGAGAGGAATGACATCTCTGTCATTGTGCCCAGCATGAGCACCAACAGCACCGTCTCCTTCCTGGTGACGTCAGACCGAGACATTGGAGATCTGCTGATGCTGAAGCTGCACTGGGAGAAAGACTCGTATCTCTACAGCTTCTTCAGCAGTAATCAGTTCACCATCCGCAGAATGAGGATCAAATCTGGAGAAACGCAGGCCAAAGTAATCTTCCGAGCCAAAGAGACAGAGTTTGCTTCTCTGGTTCAGGGTGGAGATCCAGTGGTGTTTGTGAAGTCCAGTGAAACTCCACAGAGCAGGAGAGAAGAGAGGAAGCACCGACTGAAACATCACGGCAGCTTCTTCAAACAGGGCATCAATGAAGCCACAGCAGATCTGAGGAAACCGCCAGCAGCGCTACACAACAATCAATCAACAGAGACGACAACAACAGCTAACACAAGTCAGGTCAACACAGAACACTGGACTGGGATTTAA

Function

symbol description
lpl Predicted to enable apolipoprotein binding activity; lipoprotein lipase activity; and phospholipase activity. Acts upstream of or within definitive hemopoiesis and response to (R)-carnitine. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of chylomicron and very-low-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; head; immature eye; midbrain; and ovary. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein lipase).

GO:

id name namespace
GO:0006629 lipid metabolic process biological_process
GO:0061959 response to (R)-carnitine biological_process
GO:0006633 fatty acid biosynthetic process biological_process
GO:0019433 triglyceride catabolic process biological_process
GO:0016042 lipid catabolic process biological_process
GO:0005576 extracellular region cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005615 extracellular space cellular_component
GO:0034361 very-low-density lipoprotein particle cellular_component
GO:0042627 chylomicron cellular_component
GO:0016020 membrane cellular_component
GO:0004465 lipoprotein lipase activity molecular_function
GO:0034185 apolipoprotein binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0052689 carboxylic ester hydrolase activity molecular_function
GO:0008201 heparin binding molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0004620 phospholipase activity molecular_function
GO:0016298 lipase activity molecular_function

KEGG:

id description
ko00561 Glycerolipid metabolism
ko03320 PPAR signaling pathway
ko04979 Cholesterol metabolism
ko05010 Alzheimer disease
ko04147 Exosome
ko00536 Glycosaminoglycan binding proteins
ko00537 Glycosylphosphatidylinositol (GPI)-anchored proteins

ZFIN:

id description
ZDB-GENE-990415-139 Predicted to enable apolipoprotein binding activity; lipoprotein lipase activity; and phospholipase activity. Acts upstream of or within definitive hemopoiesis and response to (R)-carnitine. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of chylomicron and very-low-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; head; immature eye; midbrain; and ovary. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein lipase).

Ensembl:

ensembl_id ENSDARG00000098720

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00031643 True 1727 mRNA 0.48 10 55365727 55390332

Neighbor

gene id symbol gene type direction distance location
XLOC_015968 NA coding upstream 96437 55268020 ~ 55269290 (+)
XLOC_015967 cib3 coding upstream 98756 55249838 ~ 55266971 (+)
XLOC_015966 zmp:0000000521 coding upstream 140699 55199721 ~ 55225028 (+)
XLOC_015965 rnf126 coding upstream 385577 54844755 ~ 54980150 (+)
XLOC_015964 twsg1a coding upstream 530963 54798689 ~ 54834764 (+)
XLOC_015970 ap1m1 coding downstream 39656 55429988 ~ 55492315 (+)
XLOC_015971 NA coding downstream 212796 55603128 ~ 55603565 (+)
XLOC_015972 klf2b coding downstream 274763 55665095 ~ 55673225 (+)
XLOC_015973 NA coding downstream 387490 55777822 ~ 55780037 (+)
XLOC_015974 NA coding downstream 392205 55782537 ~ 55784445 (+)
XLOC_015960 CABZ01050280.1 non-coding upstream 918014 54430632 ~ 54447713 (+)
XLOC_015959 NA non-coding upstream 937789 54425088 ~ 54427938 (+)
XLOC_015956 CU179656.2 non-coding upstream 1051518 54305610 ~ 54314209 (+)
XLOC_015955 NA non-coding upstream 1095361 54085893 ~ 54270366 (+)
XLOC_015978 NA non-coding downstream 734671 56125003 ~ 56130443 (+)
XLOC_015981 NA non-coding downstream 781761 56172093 ~ 56172528 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000075_01015651_01022674 NA coding CI01000075 null 1015651 ~ 1022813 (+)
bowfin (Amia calva) AMCG00006014 NA coding CM030142.1 CM030142.1 14264388 ~ 14272009 (-)