| Item | Value |
|---|---|
| gene id | XLOC_025200 |
| gene name | stat3 |
| gene type | coding |
| species | zebrafish (Danio rerio) |
| category of species | model fish |
| Item | Value |
|---|---|
| chromosome id | NC_007114.7 |
| NCBI id | CM002887.2 |
| chromosome length | 62628489 |
| location | 17030665 ~ 17107445 (+) |
| genome version | GRCz11_2017_zebrafish_Genome |
| symbol | description |
|---|---|
| stat3 | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; cardiac muscle tissue regeneration; and generation of neurons. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including blastomere; epidermal superficial stratum; head; immature eye; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3). |
| id | name | namespace |
|---|---|---|
| GO:0042074 | cell migration involved in gastrulation | biological_process |
| GO:0019221 | cytokine-mediated signaling pathway | biological_process |
| GO:0001736 | establishment of planar polarity | biological_process |
| GO:0006355 | regulation of transcription, DNA-templated | biological_process |
| GO:0042127 | regulation of cell population proliferation | biological_process |
| GO:0060119 | inner ear receptor cell development | biological_process |
| GO:0006952 | defense response | biological_process |
| GO:0003401 | axis elongation | biological_process |
| GO:0060397 | growth hormone receptor signaling pathway via JAK-STAT | biological_process |
| GO:0007259 | receptor signaling pathway via JAK-STAT | biological_process |
| GO:0001501 | skeletal system development | biological_process |
| GO:0033210 | leptin-mediated signaling pathway | biological_process |
| GO:0001837 | epithelial to mesenchymal transition | biological_process |
| GO:0043434 | response to peptide hormone | biological_process |
| GO:0031099 | regeneration | biological_process |
| GO:0061026 | cardiac muscle tissue regeneration | biological_process |
| GO:0035677 | posterior lateral line neuromast hair cell development | biological_process |
| GO:0060252 | positive regulation of glial cell proliferation | biological_process |
| GO:0030010 | establishment of cell polarity | biological_process |
| GO:0008045 | motor neuron axon guidance | biological_process |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | biological_process |
| GO:0008360 | regulation of cell shape | biological_process |
| GO:0008361 | regulation of cell size | biological_process |
| GO:0060042 | retina morphogenesis in camera-type eye | biological_process |
| GO:0007165 | signal transduction | biological_process |
| GO:0005829 | cytosol | cellular_component |
| GO:0005634 | nucleus | cellular_component |
| GO:0005737 | cytoplasm | cellular_component |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | molecular_function |
| GO:0003677 | DNA binding | molecular_function |
| GO:0003700 | DNA-binding transcription factor activity | molecular_function |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | molecular_function |
| id | description |
|---|---|
| ko04630 | JAK-STAT signaling pathway |
| ko04066 | HIF-1 signaling pathway |
| ko04068 | FoxO signaling pathway |
| ko04217 | Necroptosis |
| ko04550 | Signaling pathways regulating pluripotency of stem cells |
| ko04659 | Th17 cell differentiation |
| ko04062 | Chemokine signaling pathway |
| ko04920 | Adipocytokine signaling pathway |
| ko04917 | Prolactin signaling pathway |
| ko04935 | Growth hormone synthesis, secretion and action |
| ko05200 | Pathways in cancer |
| ko05206 | MicroRNAs in cancer |
| ko05205 | Proteoglycans in cancer |
| ko05207 | Chemical carcinogenesis - receptor activation |
| ko05203 | Viral carcinogenesis |
| ko05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| ko05212 | Pancreatic cancer |
| ko05221 | Acute myeloid leukemia |
| ko05223 | Non-small cell lung cancer |
| ko05161 | Hepatitis B |
| ko05160 | Hepatitis C |
| ko05171 | Coronavirus disease - COVID-19 |
| ko05162 | Measles |
| ko05163 | Human cytomegalovirus infection |
| ko05167 | Kaposi sarcoma-associated herpesvirus infection |
| ko05169 | Epstein-Barr virus infection |
| ko05145 | Toxoplasmosis |
| ko05321 | Inflammatory bowel disease |
| ko05417 | Lipid and atherosclerosis |
| ko04931 | Insulin resistance |
| ko04933 | AGE-RAGE signaling pathway in diabetic complications |
| ko01521 | EGFR tyrosine kinase inhibitor resistance |
| ko03000 | Transcription factors |
| id | description |
|---|---|
| ZDB-GENE-980526-68 | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; cardiac muscle tissue regeneration; and generation of neurons. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including blastomere; epidermal superficial stratum; head; immature eye; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3). |
| ensembl_id | ENSDARG00000022712 |
| RNA id | representative | length | rna type | GC content | exon number | start site | end site |
|---|---|---|---|---|---|---|---|
| TCONS_00049759 | False | 2734 | mRNA | 0.50 | 22 | 17030665 | 17095351 |
| TCONS_00049758 | False | 2580 | mRNA | 0.50 | 22 | 17030665 | 17095351 |
| TCONS_00049760 | False | 3055 | mRNA | 0.48 | 24 | 17030665 | 17107445 |
| TCONS_00049761 | True | 2742 | mRNA | 0.49 | 23 | 17030704 | 17107231 |
| gene id | symbol | gene type | direction | distance | location |
|---|---|---|---|---|---|
| XLOC_025199 | cavin1a | coding | upstream | 18325 | 16976095 ~ 17012340 (+) |
| XLOC_025198 | atp6v0a1a | coding | upstream | 57540 | 16922226 ~ 16973125 (+) |
| XLOC_025197 | BX470185.1 | coding | upstream | 147361 | 16874401 ~ 16883304 (+) |
| XLOC_025196 | stk17al | coding | upstream | 157756 | 16841942 ~ 16872909 (+) |
| XLOC_025195 | lrrc3cb | coding | upstream | 256591 | 16771797 ~ 16774074 (+) |
| XLOC_025201 | stat5a | coding | downstream | 144097 | 17251542 ~ 17331919 (+) |
| XLOC_025202 | si:ch211-210g13.5 | coding | downstream | 239057 | 17346502 ~ 17523082 (+) |
| XLOC_025203 | CU207238.1 | coding | downstream | 287794 | 17395239 ~ 17461885 (+) |
| XLOC_025204 | hcrt | coding | downstream | 429907 | 17537352 ~ 17541448 (+) |
| XLOC_025205 | kcnh4a | coding | downstream | 440087 | 17547532 ~ 17604109 (+) |
| XLOC_025429 | BX649540.1 | misc | downstream | 13141294 | 30248739 ~ 30249036 (+) |
| XLOC_025188 | CR388224.1 | non-coding | upstream | 657538 | 16373012 ~ 16373127 (+) |
| XLOC_025185 | NA | non-coding | upstream | 789325 | 16186593 ~ 16241340 (+) |
| XLOC_025184 | NA | non-coding | upstream | 869206 | 16153224 ~ 16161459 (+) |
| XLOC_025183 | CR387933.1 | non-coding | upstream | 974933 | 16055009 ~ 16055732 (+) |
| XLOC_025215 | NA | non-coding | downstream | 933168 | 18040613 ~ 18061783 (+) |
| XLOC_025218 | NA | non-coding | downstream | 1082164 | 18189609 ~ 18197126 (+) |
| XLOC_025227 | NA | non-coding | downstream | 1563379 | 18670824 ~ 18672291 (+) |
| XLOC_025229 | AL772362.2 | non-coding | downstream | 1664083 | 18771528 ~ 18788485 (+) |