XLOC_005980 (adam8a)


Basic Information

Item Value
gene id XLOC_005980
gene name adam8a
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007124.7
NCBI id CM002897.2
chromosome length 52186027
location 24671481 ~ 24679636 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00011813
AGTCCCGGAGCGAGAGCACACACAGCACAGCGAGCCATGCGATACACTGGACTATTTATAACGCTGCTTTCTTTCGTTTATACATGGGAGAGTCTGGAGGCTTTACCTCATGTGATGCGCTATGATGTGGTCCGGCTTCAGGCATTGAGAGGGAGAACCAGAAGAAGCGCCTCTTCCCTCCAGaaatatcCTGAGCAACTTGAATATGATGTGGCTATAGATGGGAGAAACTTGACAATATCTTTGCACAGAAATAGAGAACTTTTAGGGAAACAATACACTTTGACACATTATGGCGAAGATGGGATTTCCGAGACAAAGTCATCAAACAAATTTAATCACTGCTACTATCATGGACACATCCATAATTTTGAAGATTCCTCAGTCAGCGTGGGACTTTGTTCTGGAATGGaAGGATTTCTGAGAGTGAACGATCAGGTTTATTTGATAGAGCCCTTGGAAGAGTCTTTGGATGGGGACCATGCTATTTACAAGCAAGAGCATTTAAGGACCAAGCGAGGGGCCTATGGATACATTAATGACACAGTCTATGACCTTGGCCCAAAGTCTAGTGGGCTGTATAAAGGAAAAAATATGAGAAACAAAGCCCCGAGAGGAGGACAGCAGATCGTTGAGATGGTTTTAGTTGTTGATAATACAGAGTACAAGAAGTTTGGAAGTTTTAAGAAAATAGAAGAAAGAATGATGCTGGTCGCAAACCACGTAGACAAGCTTTACCGGCCTTTAAACATACGTGTCATGTTGGTTGGACTGGAGGTTTGGTCTCAAAGAGACTTAATTGATGTCAGCAGTAGGCCAAATCTTACTCTGGAACGGTTTTTAAAATGGCGTCGCGATAGCCTGCTTCAGAGGAAGAAACATGATAATGCCCATTTTATTACtggtATTGATTTTGAAGGGTCCACAGTTGGGTTGGCTACATTATATGCAATGTGCTCTTCTTCATCCTCTGGTGCTGTGAATGAGGACCACAACAGCAATCCCATTGCAGTGGCTTCTACAGTTGCACATGAAATGGGACATAATCTGGGAATGTCACATGATGATTCAAGCTGTGGATGCTCCTCTAACAAGGGCTGCATTATGGGAGATACCATTGGGTCTATTTACCCAGATTCATTCAGTACTTGCAGTCAGTCATCTTTAAAGGCGTTTTTGGAGAACTATGACACCAACTGTCTAATAGATGTGCCAAATGAGGGTCAGATATATGGAGGTCCAGTTTGTGGAAATGCCTTCGTTGAAAAAGGCGAGGAGTGTGACTGCGGAACTGTTGAGGAATGCAACAACCCCTGCTGTAATGCCACCACTTGTCGACTAACTGAAGGTGCCCGTTGTGCACATGGCGAGTGCTGCCACAATTGCCAGCTGAAACATACAGGCAGCCTGTGCAGAAAAAGTGCTCACGACTGTGATTTGGACGAATACTGTACAGGAGAGTCAGCTTTCTGTCCTGAAGATGATTATAAGATGAATGGACTCCCCTGCAATTATAATCAGGGATACTGTTACAACGGACAATGTCCAACACACAAGGAACACTGCAAGATGCTGTGGGGATCAGGTGCTGATGTGGATGATGACGCCTGCTTTCAGTATAATGTGATTGACAGAACCTCCAAAAGCGCTGAACACCGAAAATGTGGGAGAATATACTGTTATGGTGGGAATCCTTTTCCAAAAACCAACAAAAAAGCAAATGTAAATGTTCAATCAAGAACCTGCTACATGGCTTTGGATTCATCACCCACAGAAGACTTAGGCATGGTTCCTACAGGCACCAAATGTGGCACAAATAAGGTGTGTTACAAAAGCCTTTGCCTCGATATCAGTATGTACGGCACTGAGAACTGCTCGAATAAATGCAACAATCGTGGGGTGTGCAACCACGAGTTGAAGTGTCACTGCGATCCAGGCTGGGCACCACCCTATTGTGATATTCAACTCTCAGAACTtcacaaaaTGAGAAAATCTGTGGTTATTGGTGTTACTACATCTTTAGCCATCCTTGTGCTGATCATTATTATTGGAGCGCTGGTgtataacagaaacaaaataacagaATTTAGAAAGAAAAGGCCACAGAAGGGCATCCACTCTTCTTCAGGCCAATGCAATCCTGCATTTCAACCAGGAAGCGCAAAGAACAGCCCCAGAATTGCACAGCCACGTATCAGTCAACCAACTTTCCTTGAGTCGTCTGCTACTCAGGCCTGTAAACCTCTTCGGTCTGCGGCTATGCCCTGTAGACCAGCACCAATGCCTCCAAAGAATGCACCACAGACCAGAAATGAACAGataatgaaGCCTCCTGTACCACCTTCTGCCATTTCCAAAAATATTTATCCTCCTCAGGCAAAACCCCTACTGCCAGCAGCTAAACCCCTGCCTCCTTCAAGACCATTACCACCACTGGCATCTAAAGCTGTGACTAAATCCAAATCACCTCCAGTGCCTCCTGTGAAACCCAGCGGGCCTCAGCCAGTATTCACTCCACCTCAGGTAATCCAGAAAGTTGCACTGAAACCTCCAGCGTGGCCCAGATGATCTGGAGCAGTATGAGTTACTATGAATCACTGGGAGCCTCAGAAGAAGCGGTTCATGAGCTGAACAAAGCTCTTTCTTTGTGGTGTGGCTCTGAATAGTAAGATGACGTTAAGGAAGGGAAAGATGGTGACCGAATTTGCACTCAAGGAATCACTCACTTTACTGATTTGGTACGATTTGTTTGTACTGTCGTCTGCTGAATTTTGTGCTTtctttattatctatttattttaggctattttaattttaaagaatgttattCAGCTGTTTACAGTCAGCAGTTTCTGACTGACTCCATGTAAGTCTACTAAGTGAGAAAGGAAAGAGTCTGTCATGCAGTATAAAAGTGTGTTCATTCATGTTTCTGAAACGTCATGTATTTGGCATTTTATATCTTTAAATTGAAatcttattttcattattttaggTAATTTCTTGTAATTTCAACATACTTTATCTATTTGGTCTTGTTTACCTCATTtcctttttacaatatttaacttTCATACGTTTTTCTTGTGATCCTTTTGCACTCAGACTAAGGCAAACATTTGTTTTGCCCGCCTAATGTTTAGACTTCAAGTTTGCAATGATCTCAGCTGGGCTGATTTTACTCTTTAAATGTGAGAATGCTCTCTTTTTTATTCTGTGTACTGTAATAAACTTTTTCACGTTTCTCAAAA
>TCONS_00011814
TCCTGAAGATGATTATAAGATGAATGGACTCCCCTGCAATTATAATCAGGGATACTGTTACAACGGACAATGTCCAACACACAAGGAACACTGCAAGATGCTGTGGGGATCAGGTGCTGATGTGGATGATGACGCCTGCTTTCAGTATAATGTGATTGACAGAACCTCCAAAAGCGCTGAACACCGAAAATGTGGGAGAATATACTGTTATGGTGGGAATCCTTTTCCAAAAACCAACAAAAAAGCAAATGTAAATGTTCAATCAAGAACCTGCTACATGGCTTTGGATTCATCACCCACAGAAGACTTAGGCATGGTTCCTACAGGCACCAAATGTGGCACAAATAAGGTCATTAAAGAATCAATGTGTAAAAATACCCAGTGGACAaaagctttatttattcatttatttccaatATATTTTTCAATCAACAGGTGTGTTACAAAAGCCTTTGCCTCGATATCAGTATGTACGGCACTGAGAACTGCTCGAATAAATGCAACAATCGTGGGGTGTGCAACCACGAGTTGAAGTGTCACTGCGATCCAGGCTGGGCACCACCCTATTGTGATATTCAACTCTCAGAACTtcacaaaaTGAGAAAATCTGTGGTTATTGGTGTTACTACATCTTTAGCCATCCTTGTGCT

Function

symbol description
adam8a Enables metallopeptidase activity and protease binding activity. Predicted to be involved in several processes, including inflammatory response; positive regulation of cellular extravasation; and positive regulation of membrane protein ectodomain proteolysis. Predicted to act upstream of or within integrin-mediated signaling pathway and proteolysis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including axial vasculature; intermediate cell mass of mesoderm; macrophage; tail bud; and yolk. Orthologous to human ADAM8 (ADAM metallopeptidase domain 8).

GO:

id name namespace
GO:0022407 regulation of cell-cell adhesion biological_process
GO:0007229 integrin-mediated signaling pathway biological_process
GO:0006954 inflammatory response biological_process
GO:0006508 proteolysis biological_process
GO:0051044 positive regulation of membrane protein ectodomain proteolysis biological_process
GO:0002693 positive regulation of cellular extravasation biological_process
GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0002020 protease binding molecular_function
GO:0004222 metalloendopeptidase activity molecular_function
GO:0008237 metallopeptidase activity molecular_function
GO:0050839 cell adhesion molecule binding molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-030616-622 Enables metallopeptidase activity and protease binding activity. Predicted to be involved in several processes, including inflammatory response; positive regulation of cellular extravasation; and positive regulation of membrane protein ectodomain proteolysis. Predicted to act upstream of or within integrin-mediated signaling pathway and proteolysis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including axial vasculature; intermediate cell mass of mesoderm; macrophage; tail bud; and yolk. Orthologous to human ADAM8 (ADAM metallopeptidase domain 8).

Ensembl:

ensembl_id ENSDARG00000001452

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00011813 False 3251 mRNA 0.43 25 24671481 24679636
TCONS_00011814 True 650 lncRNA 0.41 5 24675824 24677020

Neighbor

gene id symbol gene type direction distance location
XLOC_005979 msx3 coding upstream 6813 24662238 ~ 24664668 (+)
XLOC_005978 NA coding upstream 21542 24597665 ~ 24649939 (+)
XLOC_005977 fuom coding upstream 84998 24584401 ~ 24586483 (+)
XLOC_005976 echs1 coding upstream 89245 24579108 ~ 24582236 (+)
XLOC_005975 NA coding upstream 98553 24570620 ~ 24572928 (+)
XLOC_005981 zgc:66426 coding downstream 38 24679674 ~ 24688122 (+)
XLOC_005982 cfap43 coding downstream 38244 24717880 ~ 24743151 (+)
XLOC_005983 col17a1b coding downstream 70442 24750078 ~ 24779692 (+)
XLOC_005984 AL929005.1 coding downstream 149117 24828753 ~ 24828869 (+)
XLOC_005985 si:ch211-223p8.8 coding downstream 150360 24829996 ~ 24830717 (+)
XLOC_005962 CR352246.1 non-coding upstream 850181 23821186 ~ 23821300 (+)
XLOC_005959 NA non-coding upstream 1260971 23388493 ~ 23410510 (+)
XLOC_005957 CR356222.1 non-coding upstream 1430904 23227531 ~ 23240577 (+)
XLOC_005997 BX530079.1 non-coding downstream 764348 25443984 ~ 25444523 (+)
XLOC_006005 NA non-coding downstream 1090363 25769999 ~ 25782811 (+)
XLOC_006007 NA non-coding downstream 1264643 25944279 ~ 25961369 (+)
XLOC_006008 NA non-coding downstream 1286091 25965727 ~ 25983365 (+)

Expression


Co-expression Network