XLOC_000276 (lias)


Basic Information

Item Value
gene id XLOC_000276
gene name lias
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007112.7
NCBI id CM002885.2
chromosome length 59578282
location 23274710 ~ 23283468 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00000456
GTAGATGAATCGATGTCAGAGTGATTGTTGTCAATGACAGGCTCGAGCTGGATCTAAAGTCATGGCGTTGATCAGTAGAAGTTGTGGAGCTGCGAGCCGATATTCTTCAAGTCATCTGTTTTTACCATCTAAAGGCGCCGAGGCGGCTAATGTGTACTGTAACAGACTGAGCACTGCTGCcagcacatcatcatcatcatcaccatccaCACACAATGACAGGAAGAAAGACCTGAGGGAGGATGGACTGAACCTGCAGGACTTCATATCTGGAGAGCTGTCAGAAAAGAGCAAGTGGGAGGAATACAGAGGCAACCTAAAGAGAGAAAAAGGAGAAAGGTTAAGGCTACCACCATGGCTGAAGACAGAGATTCCTATAGGGAAAAACTACAACAAATTGAAGAATACACTTAGAGAATTAAACCTCCACACAGTCTGCGAAGAAGCCCGTTGTCCAAATATTGGTGAATGTTGGGGTGGAGGAGAGTACGCCACGGCCACAGCCACCATTATGTTAATGGGGGACACATGCACACGTGGCTGTAGGTTTTGTTCAGTTAAGACAGCGAGACGTCCTCCACCTCTTGACCCCGATGAGCCATATAACACCGCTAAAGCCATTGCAGCATGGGGTCTGGACTATGTAGTACTCACATCAGTGGACCGAGATGACATTCCTGATGGTGGCGCTGAACACTTTGCAAAGACTGTCTCCAACATTAAAGAAAGGAACTCTAAAATCTTGGTAGAGTGTTTGACTCCTGATTTCCGTGGCGATCTGGCAGCGGTGGAGAAAATTGCTTTGTCTGGCCTTGATGTTTATGCTCACAATGTAGAGACGGTCAGAGAGTTACAGAGGCATGTACGTGACCCCCGGGCAAACTTTGACCAATCACTGAGTGTTTTACGACATGCTAAAAAGGTGAAATCCAGTGTGCTCACAAAAACTTCTATCATGCTGGGGCTCGGAGAAACAGATGCACAAATACAAGCCACTTTAACAGAATTGAGGGACTCTGGTGTGGATTGTCTAACCCTGGGGCAGTACATGCAACCAACCAAACGCCATCTTAAGGTGGAAGAATATGTCACCCCTGAAAAGTTTGCGTTTTGGGAGAAGGTTGGCCAGGAGATGGGCTTCATCTACACTGCCAGTGGACCACTTGTGCGCTCGTCTTATAAAGCAGGGGAGTTCTTTTTGAAGAATCTGCTGGAAAAGAGGAAGACTGAAGAAACCACAGCAACAGCAGAGTAAACCTGCTCCACATCTCCTGTGTTCTAcagtactctctctctctctgcttaaatattaaacaatataacACTGATgctccacacaaaaatgaaagttgCCATCATTTGCTCAACCTCATGATGTTTTCTTGTGCGGAACACAACATACATACTTTAATCCTAGAGGTGAGGAAATGGTTACAGGATTCAAAATCCAGGGCTACAAAATGCCTTGAAGTATACttattacaaaataaactgcTACAGTTGCATTCTGTAAAAGTGTTTAAATAAAGATGTTGGGTTGGTTGTTTTAGAAATGAATCTCAGAATATATTAAATGAATTCTTGTCAAAGTA
>TCONS_00000457
CATTTCAGCTTTACCTACCGGCGCAGGCCAGTAACGTTACTACAGAAGTTATTGCAACACACTCACTTGTCAAATGTAACATTAGTCAAATTAAGCGGAATGTTTTCACGTTATTAGCAGAGCTTGTGTTATAGTGCATGTGTTCATTTACAAGGTGTACTGTAACAGACTGAGCACTGCTGCcagcacatcatcatcatcatcaccatccaCACACAATGACAGGAAGAAAGACCTGAGGGAGGATGGACTGAACCTGCAGGACTTCATATCTGGAGAGCTGTCAGAAAAGAGCAAGTGGGAGGAATACAGAGGCAACCTAAAGAGAGAAAAAGGAGAAAGGTTAAGGCTACCACCATGGCTGAAGACAGAGATTCCTATAGGGAAAAACTACAACAAATTGAAGAATACACTTAGAGAATTAAACCTCCACACAGTCTGCGAAGAAGCCCGTTGTCCAAATATTGGTGAATGTTGGGGTGGAGGAGAGTACGCCACGGCCACAGCCACCATTATGTTAATGGGGGACACATGCACACGTGGCTGTAGGTTTTGTTCAGTTAAGACAGCGAGACGTCCTCCACCTCTTGACCCCGATGAGCCATATAACACCGCTAAAGCCATTGCAGCATGGGGTCTGGACTATGTAGTACTCACATCAGTGGACCGAGATGACATTCCTGATGGTGGCGCTGAACACTTTGCAAAGACTGTCTCCAACATTAAAGAAAG

Function

symbol description
lias Predicted to enable lipoate synthase activity. Predicted to be involved in lipoate biosynthetic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase).

GO:

id name namespace
GO:0009249 protein lipoylation biological_process
GO:0009107 lipoate biosynthetic process biological_process
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0016992 lipoate synthase activity molecular_function
GO:0016740 transferase activity molecular_function
GO:0046872 metal ion binding molecular_function
GO:0102552 lipoyl synthase activity (acting on glycine-cleavage complex H protein molecular_function
GO:0102553 lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein) molecular_function
GO:0051536 iron-sulfur cluster binding molecular_function
GO:0051539 4 iron, 4 sulfur cluster binding molecular_function
GO:0003824 catalytic activity molecular_function

KEGG:

id description
ko00785 Lipoic acid metabolism
ko02020 Two-component system
ko01001 Protein kinases
ko02022 Two-component system

ZFIN:

id description
ZDB-GENE-040426-1528 Predicted to enable lipoate synthase activity. Predicted to be involved in lipoate biosynthetic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase).

Ensembl:

ensembl_id ENSDARG00000022845

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00000456 False 1592 mRNA 0.44 11 23274710 23283468
TCONS_00000457 True 732 processed_transcript 0.46 6 23274922 23279702

Neighbor

gene id symbol gene type direction distance location
XLOC_000274 si:dkey-92j12.5 coding upstream 34664 23161369 ~ 23240046 (+)
XLOC_000273 BX908795.1 coding upstream 398536 22842935 ~ 22876174 (+)
XLOC_000272 zmynd10 coding upstream 571327 22691256 ~ 22703383 (+)
XLOC_000271 anxa5b coding upstream 609612 22654875 ~ 22665098 (+)
XLOC_000270 CR376846.1 coding upstream 753384 22521212 ~ 22521326 (+)
XLOC_000277 ube2kb coding downstream 28149 23311617 ~ 23322969 (+)
XLOC_000278 n4bp2 coding downstream 89002 23372470 ~ 23396454 (+)
XLOC_000279 rhoh coding downstream 114937 23398405 ~ 23398992 (+)
XLOC_000280 chrna9 coding downstream 122935 23406403 ~ 23417937 (+)
XLOC_000281 NA coding downstream 205643 23489111 ~ 23506518 (+)
XLOC_000269 NA non-coding upstream 755956 22510734 ~ 22518754 (+)
XLOC_000263 NA non-coding upstream 1773226 21500645 ~ 21501484 (+)
XLOC_000262 NA non-coding upstream 1933057 21331425 ~ 21341653 (+)
XLOC_000260 CR762427.1 non-coding upstream 2020228 21254353 ~ 21254482 (+)
XLOC_000283 CT573447.1 non-coding downstream 467631 23751099 ~ 23751213 (+)
XLOC_000285 dre-mir-218a-2 non-coding downstream 583410 23866878 ~ 23866965 (+)
XLOC_000287 BX119984.1 non-coding downstream 831057 24114525 ~ 24114558 (+)
XLOC_000288 NA non-coding downstream 834899 24118367 ~ 24119067 (+)

Expression


Co-expression Network