XLOC_030478 (ntrk2b)


Basic Information

Item Value
gene id XLOC_030478
gene name ntrk2b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007116.7
NCBI id CM002889.2
chromosome length 72500376
location 55626693 ~ 55689656 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00059539
CGCGGTATCACCTTTTCGCGGAGACCAGATAAGGCCACTCCATGACAGTCTGGCGTCGCGCACAACGTCTTTGCGCATCCCACAGCAGCGGCGTCTCATCTCGGAATTGCTGAAAATACTACAAGACACTACACAACGCCGAACGCACCGCGCTAGACCTGCTATGACCGCAGGGGTTCGTGGAATGGCTTGCTGGGGGTTGTGTGGGTTTTTATTCGGGCTGCTGAGGATCAGCTCGGCTTGTCCTGTGTCGTGCTTTTGCAATGCCTCAAGGATCTCGTGTATCGATCAAGAACCAGGGATCGAGGATTTCCCTGTCTTGATGCCGGAGTCTGACATGGAGAACATCACGGATATATATATATCAAATCAAAAAAGGCTATTTACAATCAACGAGGACCACATGAAGTTCTACTCGAATCTCAGGAATTTAACAGTGACCAATACCCACCTGACATATGTATCTACCATGGCCTTTTTCAACAATTCCAAGCTTCAATATCTGAATCTCGGAGACAATAACTTATCAACACTCTCTTGGATGGCAATGCGGAATTCAAACGTATCAACTTTGTTGCTCTCTGGGAACCCTTTGCAATGTGCATGTGAGAACATCTGGATCAAACTCTGGTTGGATGACAGTGAAAGAGACGTTCTGCAGTGTCTACAGGAAGGAGGAAAAGCAAAAACCCTGTCTAGACTCACTCTGCCTTTATGTGAGCATCCACGTGTCGAGGTATTCCCCACTGACGTTAGTCAAATGGCAGGAAGTGATGCTACAGTGATATGTAACGCATCAGGTTCCCCGACCCCAGAGCTCACTTGGACCTTAAATTCCAGCGAACACCCTCCTCTCTCAACCAGCCACGAGATCAGCAAAATGGACCTGCAGTCGGTGCTGACTCTAAATGGACTTTCGCCTAATGACAATGGCAGAAAGCTCATTTGTAGTGCTGAAAACATCGTGGGCCAGATCGAGGCTACAGTCATGCTCAATATTTCTTTTCCCCCTACTGTCTTGGAGCTGTACCTGCCCGAGAGGAGCCAGGACTGGTGCATCCCTTTCGTTGTGACGGGCAACCCGAGACCTGACCTCCACTGGTACCATGAGGGAAAGCCGCTAGAGGAGCAGGAGTACATCAGAACTGAAATCCACGATATCACCAATACCGAGTACCACGGCTGTCTGAAGCTGGACACCCCCACTCACATCCATAATGGCATTTACACGCTGGTGGCCAGCAATGAGTTCGGAGAGGACAGAGGGAACGTGACGGCACACTTCATGCGCATACCTGACGTGGATCATTCAGGGATAGagGGAGTGTTCTATTATGaCACAACTGTTAGTCCGGatatcCCACCACTGGAGGACAGAGTTGCGGTTTACATAGTAGTGGGAATAGCTGGGGTTGCTTTAACTGGATGCATCCTGATGTTAGTTTTCCTCAAGTATGGCAGAAGCTCCAAATTTGGAATGAAAGGCTCCTCGTCTGTCATTAGTAATGATGATGACTCTGCCAGCCCGCTCCACCACGTTTCCAACGGCAACAACACGCCATCATCCTCGGAGATGGGTCCTGATGCAGTTATTATTGGAATGACAAAGATTCCAGTCATTGAGAACCCTCAGTACTTCCGCAACCCTGGCAGCATGCTGAAATCGGACACTCttGTCCAACATATAAAGCGTCACAACATTTTACTGAAGAGGGAGCTGGGAGAGGGGGCTTTCGGGAAAGTGTTCTTAGCTGAATGCTACAACTTGTCTCCTGACCAAGAGAAGATTTTGGTGGCTGTTAAGACTTTGAAAGAAGCCAGTGAAAGTGGGCGAGCAGATTTCCACAGAGAGGCAGAACTCCTGACCAACCTGCAGCATGAGCACATTGTCAAATTTTACGGCGTGTGTGTAGAAAGTGACCCCCTCATTATGGTGTTTGAGTACATGAAACACGGAGATCTCAACAAGTTTCTCAGGGCTCATGGTCCAGATGCGGTGCTAATGGCAGACGGACAGCAGAGTTTGCTGGTGGAGTTGACTCAGCCTCAGATGCTGCACATTGCTCAGCAGATAGCAGCAGGAATGGTGTATCTGGCTTCACAGCATTTTGTGCACAGAGACCTGGCCACACGCAACTGCCTGGTGGGGGAAAACCTGCTTGTAAAGATAGGAGACTTTGGCATGTCCAGAGATGTGTACAGCACCGACTACTATAGGGTGGGTGGTCACACCATGCTGCCCATCCGATGGATGCCCCCAGAGAGCATTATGTACAGAAGATTCACCACAGAGAGTGACGTGTGGAGTTTGGGTGTAGTACTCTGGGAAATCTTCACCTATGGCAAGCAACCCTGGTATCAGCTCTCAAACAATGAGGTGATCGAGTGTATCACACAGGGTCGGGTGTTACAGAGACCTCGTACTTGCCCCAAAGAAGTGTATGATCTGATGCTGGGCTGCTGGCAGAGGGAGCCATACATGAGACTCAACATCAAAGAAATCCACAATCTGCTCCAGAGCCTGGCCAAGGCCTCGCCTGTGTACCTGGACATCCTGGGCTAA
>TCONS_00059540
CGCGGTATCACCTTTTCGCGGAGACCAGATAAGGCCACTCCATGACAGTCTGGCGTCGCGCACAACGTCTTTGCGCATCCCACAGCAGCGGCGTCTCATCTCGGAATTGCTGAAAATACTACAAGACACTACACAACGCCGAACGCACCGCGCTAGACCTGCTATGACCGCAGGGGTTCGTGGAATGGCTTGCTGGGGGTTGTGTGGGTTTTTATTCGGGCTGCTGAGGATCAGCTCGGCTTGTCCTGTGTCGTGCTTTTGCAATGCCTCAAGGATCTCGTGTATCGATCAAGAACCAGGGATCGAGGATTTCCCTGTCTTGATGCCGGAGTCTGACATGGAGAACATCACGGATATATATATATCAAATCAAAAAAGGCTATTTACAATCAACGAGGACCACATGAAGTTCTACTCGAATCTCAGGAATTTAACAGTGACCAATACCCACCTGACATATGTATCTACCATGGCCTTTTTCAACAATTCCAAGCTTCAATATCTGAATCTCGGAGACAATAACTTATCAACACTCTCTTGGATGGCAATGCGGAATTCAAACGTATCAACTTTGTTGCTCTCTGGGAACCCTTTGCAATGTGCATGTGAGAACATCTGGATCAAACTCTGGTTGGATGACAGTGAAAGAGACGTTCTGCAGTGTCTACAGGAAGGAGGAAAAGCAAAAACCCTGTCTAGACTCACTCTGCCTTTATGTGAGCATCCACGTGTCGAGGTATTCCCCACTGACGTTAGTCAAATGGCAGGAAGTGATGCTACAGTGATATGTAACGCATCAGGTTCCCCGACCCCAGAGCTCACTTGGACCTTAAATTCCAGCGAACACCCTCCTCTCTCAACCAGCCACGAGATCAGCAAAATGGACCTGCAGTCGGTGCTGACTCTAAATGGACTTTCGCCTAATGACAATGGCAGAAAGCTCATTTGTAGTGCTGAAAACATCGTGGGCCAGATCGAGGCTACAGTCATGCTCAATATTTCTTTTCCCCCTACTGTCTTGGAGCTGTACCTGCCCGAGAGGAGCCAGGACTGGTGCATCCCTTTCGTTGTGACGGGCAACCCGAGACCTGACCTCCACTGGTACCATGAGGGAAAGCCGCTAGAGGAGCAGGAGTACATCAGAACTGAAATCCACGATATCACCAATACCGAGTACCACGGCTGTCTGAAGCTGGACACCCCCACTCACATCCATAATGGCATTTACACGCTGGTGGCCAGCAATGAGTTCGGAGAGGACAGAGGGAACGTGACGGCACACTTCATGCGCATACCTGACGTGGATCATTCAGGGATAGagGGAGTGTTCTATTATGaCACAACTGTTAGTCCGGatatcCCACCACTGGAGGACAGAGTTGCGGTTTACATAGTAGTGGGAATAGCTGGGGTTGCTTTAACTGGATGCATCCTGATGTTAGTTTTCCTCAAGTATGGCAGAAGCTCCAAATTTGGAATGAAAGGCTCCTCGTCTGTCATTAGTAATGATGATGACTCTGCCAGCCCGCTCCACCACGTTTCCAACGGCAACAACACGCCATCATCCTCGGAGATGGGTCCTGATGCAGTTATTATTGGAATGACAAAGATTCCAGTCATTGAGAACCCTCAGTACTTCCGCAACCCTGGCAGCATGCTGAAATCGGACACTCttGTCCAACATATAAAGCGTCACAACATTTTACTGAAGAGGGAGCTGGGAGAGGGGGCTTTCGGGAAAGTGTTCTTAGCTGAATGCTACAACTTGTCTCCTGACCAAGAGAAGATTTTGGTGGCTGTTAAGACTTTGAAAGAAGCCAGTGAAAGTGGGCGAGCAGATTTCCACAGAGAGGCAGAACTCCTGACCAACCTGCAGCATGAGCACATTGTCAAATTTTACGGCGTGTGTGTAGAAAGTGACCCCCTCATTATGGTGTTTGAGTACATGAAACACGGAGATCTCAACAAGTTTCTCAGGGCTCATGGTCCAGATGCGGTGCTAATGGCAGACGGACAGCAGAGTTTGCTGGTGGAGTTGACTCAGCCTCAGATGCTGCACATTGCTCAGCAGATAGCAGCAGGAATGGTGTATCTGGCTTCACAGCATTTTGTGCACAGAGACCTGGCCACACGCAACTGCCTGGTGGGGGAAAACCTGCTTGTAAAGATAGGAGACTTTGGCATGTCCAGAGATGTGTACAGCACCGACTACTATAGGGTAAGTGTGGGTGGTCACACCATGCTGCCCATCCGATGGATGCCCCCAGAGAGCATTATGTACAGAAGATTCACCACAGAGAGTGACGTGTGGAGTTTGGGTGTAGTACTCTGGGAAATCTTCACCTATGGCAAGCAACCCTGGTATCAGCTCTCAAACAATGAGGTGATCGAGTGTATCACACAGGGTCGGGTGTTACAGAGACCTCGTACTTGCCCCAAAGAAGTGTATGATCTGATGCTGGGCTGCTGGCAGAGGGAGCCATACATGAGACTCAACATCAAAGAAATCCACAATCTGCTCCAGAGCCTGGCCAAGGCCTCGCCTGTGTACCTGGACATCCTGGGCTAATCCTTTTGCCAGTATGGGCGTGAAATTATTAGTAAGAAAGagtgtct

Function

symbol description
ntrk2b Predicted to enable brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor-activated receptor activity. Acts upstream of or within neuromast primordium migration. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in gut and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).

GO:

id name namespace
GO:1990090 cellular response to nerve growth factor stimulus biological_process
GO:0033674 positive regulation of kinase activity biological_process
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus biological_process
GO:0007275 multicellular organism development biological_process
GO:0010976 positive regulation of neuron projection development biological_process
GO:0043408 regulation of MAPK cascade biological_process
GO:0043410 positive regulation of MAPK cascade biological_process
GO:0006468 protein phosphorylation biological_process
GO:0048882 lateral line development biological_process
GO:0048883 neuromast primordium migration biological_process
GO:0099551 trans-synaptic signaling by neuropeptide, modulating synaptic transmission biological_process
GO:0051896 regulation of protein kinase B signaling biological_process
GO:0007399 nervous system development biological_process
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling biological_process
GO:0016310 phosphorylation biological_process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway biological_process
GO:0030424 axon cellular_component
GO:0005887 integral component of plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0043235 receptor complex cellular_component
GO:0016740 transferase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0060175 brain-derived neurotrophic factor-activated receptor activity molecular_function
GO:0000166 nucleotide binding molecular_function
GO:0043121 neurotrophin binding molecular_function
GO:0004672 protein kinase activity molecular_function
GO:0016301 kinase activity molecular_function
GO:0004713 protein tyrosine kinase activity molecular_function
GO:0004714 transmembrane receptor protein tyrosine kinase activity molecular_function
GO:0048403 brain-derived neurotrophic factor binding molecular_function
GO:0005030 neurotrophin receptor activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-010126-2 Predicted to enable brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor-activated receptor activity. Acts upstream of or within neuromast primordium migration. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in gut and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).

Ensembl:

ensembl_id ENSDARG00000098511

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00059539 False 2563 mRNA 0.50 18 55626693 55689609
TCONS_00059540 True 2616 mRNA 0.49 18 55626693 55689656

Neighbor

gene id symbol gene type direction distance location
XLOC_030477 pcsk5a coding upstream 277264 55265274 ~ 55349429 (+)
XLOC_030476 tmc2a coding upstream 374699 55221593 ~ 55251994 (+)
XLOC_030475 NA coding upstream 472444 55146633 ~ 55154249 (+)
XLOC_030474 NA coding upstream 486556 55134605 ~ 55140137 (+)
XLOC_030473 CU207241.1 coding upstream 503473 55119510 ~ 55123220 (+)
XLOC_030480 NA coding downstream 28069 55717725 ~ 55719138 (+)
XLOC_030481 NA coding downstream 215477 55905133 ~ 55906713 (+)
XLOC_030482 tmem150ab coding downstream 244473 55934129 ~ 55952128 (+)
XLOC_030483 fkbp6 coding downstream 294614 55984270 ~ 55989773 (+)
XLOC_030484 fzd9a coding downstream 333530 56023186 ~ 56027776 (+)
XLOC_030472 NA non-coding upstream 552493 55065782 ~ 55074200 (+)
XLOC_030470 NA non-coding upstream 915038 54711023 ~ 54711655 (+)
XLOC_030485 NA non-coding downstream 404274 56093930 ~ 56094196 (+)
XLOC_030487 NA non-coding downstream 495209 56184865 ~ 56185944 (+)
XLOC_030488 CR753837.2 non-coding downstream 557080 56246736 ~ 56248735 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000059_01080401_01106181 NTRK2B coding CI01000059 null 1079835 ~ 1106239 (+)
bowfin (Amia calva) AMCG00007839 LOC108438531,LOC107714007,LOC108269325,LOC107654144 coding CM030123.1 CM030123.1 32325622 ~ 32356646 (+)