XLOC_003907 (apc2)


Basic Information

Item Value
gene id XLOC_003907
gene name apc2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007122.7
NCBI id CM002895.2
chromosome length 45484837
location 7281240 ~ 7320211 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00007482
GGGAGATAGGCGTGACATCAGAGCGCGCAGCATCACTGAATGCAGGGCATCATCCCCACAGAGAAAGACAGCAGCGCCTCCACGCCCAGTAAACACCACCAATGCTGCTGAACATGAGGGATCCCATCGAGTGATGATGTCATTCCCAACGGCCTCCTATGACCAGCTGGTGCGGCAGGTGGAGGATCTCCGTAAGGAGAACTCTCACCTGCGGCGAGAGCTTCAGGACAACTCACACCACCTGTCTAAGCTGGAGAATGAAACATCTGACATGAAGGAGGTTCTGAGGCAGTTGCAGAGTAAACTGGAGCAGGAGGCCGGAACGCTTGCCTCTTCAGGCAGAACTGATGTGCTGGACCAGCTCAAAGAGTTGCATATGGACCTGACCAACTACTACGAGCTAAAGTACCAGCCTCACAACTTACGTGTGTTTCCGGAGCTGATGGCTGGCCAGGTAGGGGAAGGTGAGGAGAGACTGAGCATCAGCAGATCCAGGAGCCCCGTGTGTCAATCGTCCCGCCAGTCCTCATCTGCATCTGGAGAAGGAACAGCCGTGCACCCAGGCCTCCCTCATCAGGTGGCTGGAGAAGGACGTATCACTGCCCAACACTTAGAGGATCTCTGTAAAGAGAGgaCTATGTTGCTGAGTGAAATAGAGAAAGAGGAGAAAGAGCGACGGTGGTATTACTCACAGCTGCAGGGATTGTCTCAGAGACTGGCTGAACTGCCACGGCTTGATACGTTCTCTATGCAGGTGGATTTTATCAGACAGCAGCTGGAGTTTGAAGCTCAGCAGCTGCGTTCTGTGATGGAGGAACGTTTCGGCACCAGTGATGAGATGGTCCAGAGAACACAAATCCGTGTTGCTCGGTTGGAACAGCTAGAGAAAGAGCTTCATGATGCCCAGAGCTCACGTGGTCCTCAAGAGAAGAGCGCTCTACCTGAAACACAgAGCACCGAGTGCCTCCCAAAAGCATCTGTTCCTGACTTGGATACTGGAAATGCTGGTACTCTGGATGCTCCTGGAGAAGCAGGGAGCAAAGTGGAGATGGTGTTTTGGCTACTTTCCATGCTGGCCTCCAGAGATCGGGAGGAAATGTCCCGTACCCTTCTGGCAATGTCAAGCTCACAGGAAAGCTGCATTGCTATGCGCAAGTCTGGCTGTGTCCCGCTGCTTGTACAAATACTACACGAGGGGGGCACCGGGGAGGCAGCTGGGACAGGATGCTACAGTCGAGAAGCCCGTTCCAGAGCCAGTGCTGCACTGCACAACATCGTGTATTCACAGCCAGATGAGGGTCAAGCACGACGTGAGATGAGAGTTCTCCATGTGCTGGAGCAGATTCGCTCCCACTGCGAAAATGGATGGGACTGGATTGAGAACCATTTAAGTACCCCTTCACCCGGTGGTAGCAAAACCACAGAAATCCCTGAGCCAGTGGATCCCCAGATATGCCAGGCCTTGTGTGCAATAATGAAGTTATCTTTCGAGGAAGAGTATCGCAGGGCAATGAATGAACTAGGGGGCCTCCAAGCTATAGCGGAGCTAATGCAGCTGGACCAAGAACTGTATGGCATGCACAATGAGCCAATCAATATGGCTCTCCGGCGTTACGCAGGAATGGCGGTCACTAATCTTACATATGGAGATGTTGTAAATAAGGCTACACTTTGCTCAAAGAAAAATTGTCTTCAAGCCATCGTTGCACAGCTAGCATCAGATAGCGAGGAATTACAGCAGGTTGTGTCAAGTATACTAAGAAACCTGTCATGGCGTGCTGATATCAATAGTAAGAGGGCTTTGAGGGATGTCGGCAGTGTATCAGGACTTATGACTTGTGCATTGCAGGCTACAAAGGAATCCACATTAAAGAGTGTGTTAAGTGCACTGTGGAATTTGTCAGCGCACAGCACTGAGAATAAGGTGGCAATTTGCTCTGTTGATGGTGCTCTTGGCTTTTTGGTTAGCACTTTGACTTACCGATGCCAAACCAACTCACTGGCCATTATTGAGAGCGGTGGAGGCATTCTGCGCAATGTGTCCAGCCTCATCGCCACCCGAGATGATTACAGGCAAATCCTCAGGGATCATAACTGCCTTCAGACTCTGCTACAGCATTTGCGATCTCACAGTTTGACTATTGTGAGTAATGCGTGTGGAACCCTCTGGAACCTGTCTGCACGAAGTCCAAAAGACCAGGAATTGCTGTGGGATCTGGGAGCTGTAAGCATGCTACGCAATCTCATCAACTCAAAGCACAAAATGATAGCCATGGGAAGTGCTGCAGCTCTGCGAAACCTCCTCACAAATCGTCCACTCAAATATAAAGATGCAGCTGTTATATCCCCGGGATCATGCATGCCGTCCCTCTATATGAGGAAGCAGAAAGCATTAGAGGCTGAGTTGGATGCAAAGCATCTAGCAGAAACATTTGACACACTTGAGAAGCAAAGTTTCAAGCATGCCAATATAAACAAGCCATTGAGGCATATTGAGAGCCTAGCAAAGGACTATGCTTCAGATTCAGGCTGTTTTGATGATGATGAAGCACCTAATGTATCCACCAGCCTGGACACTGGGACATTTTCCATGCTCTCCATGTTCTTGAACAATTCTAACTTCCTTAATACGCAGCTTCGTAAGCGCGAGGGGGAGCCCGAGCAAGACATTGAAACCTTTCAAACAGACATTAAAAGATCACAACCTCCTGACGACGAAGTGACTGTGGCAGCTGAAAAATTGGCCAAGAAGATCACCAACACAGTGGCTAAAATTGACAAACTGGTAGATGACATTACCATGCATACATCATCAGAGGACAGCTTCAGTCTCAGTTCAGAAGATCATTTTTTGGATTGGAATTACGGGCCAGATGAGCTTCATGAAGCGAGAGCCATTTCATGCTCCCCATGTCCTCTCTCAGATAGCAGCACTTTTTCTCCTAAAGAGCGTCTCAGCAGAGCACATGCCTTTATGCGTCTTAAAACAACAAACTCAAGCTTATCCAATGACAGCCTTAACAGTGGTAGCATCAGTGATGGCTATTGTGGCAGTCAAGACCAGACTCATCCCTCTGCCAGACCAACAGAACAACGACGTCCAAATAAGCTTGACCTTAAGGTAGCTCATGAGGAACCACTGACTAGTGGTGTACATATTTCAAGAGTCTTGTGTCAAAATGAAATACCTGAAAGAGATTTCGAGGCAAACAAAGATGCTATTTTGCCTGATTCAGGATCCACAGATACAGAGAAAAGCCAAGAGCCATTTATATCAACCCCTGCAACTGTTTCAACAAAGGTTTCTTCAGAAACTAGCATACCAACTGTCAAGTTGTCTCCCTCCTATCAGCATGTTCCACTGATCCAGAGTGTTGCCAAGTTTGGTGTTGCAAAGACTGCAATTAATGTTCAGGCAGCTCAAGCAATGCGCAGGCAAGCTTGGGTTCCAGCAGTTATGACTGGTGGAAGCATTAGCAAGTTTTCCCCAATATGTTCTGCAAGAAGTCCCACAATAGGACAGCTGGAAACTCCTCAGAAGTATTCTGTAGAGAACACTCCAATATGCTTCTCTCGTTGCAGTTCTCTGTCCTCTTTGTCCTCTGGGGATGGAGCTCTTGATGGACAAAGTCAAACTGAAAATGAGCTAGAAAGTGACTCCTCATTGGAAATCATAGAGGTAGAAGACGTGAATGTTGAGAGAAAAGATGAAGAGGATGAGAACGAGACACTTGATGACTTGAGTGACAGTCAGTTATTAGTAACTGATCAGAAAATCAGTAGCTCTGACCCAATTGAGATCTCTGGTACAATCAAAAATGAGAAGAGGTTCCTTAGAGGAGTGTCCCCAGTAATACTTGAGGACAGGACGCCATCCAGTTCTTCGGACAACTACATTCACGAAACACCTCTTGTAATGAGTCGCTGTAGTTCAGTGAGCTCACTTGGCAGCTTTGAATCTCCTTCAATTGCCAGCTCTATTCAGAGTGATCCATGTAGTGAAATGATAAGTGGAACTGTAAGCCCCAGTGACCTACCAGACAGCCCGGGACAAACAATGCCTCCTAGTCGCAGTAAAACTCCATGCTGTCCAGAGTCAGGTGGAGCAGATGCTCAGAATCTTAGTGGTGTAGGAAGCCAATGGGAGAGTAGTTTGCGCAAGTTTATGGAAATTGCAGACTTTAAAGAAAGGTTTAACCTACCTCAGGATTTGGACACAATGATCTATTTCACTGTGGAAAAGCCGATTGAGAATTTCTCGTGTGCCTCAAGTCTGAGTGCCCTTCCACTGCATGAACACTATGTTCAGAAAGATGTGGAGCTCAAACTTACCCCTTTGCTAAAccaacaagacaatgatccagAGGAGTCTGAAAAAGAAGAGGATATGGAAGACCAATATAGTGAAGGCAACTCAGATGATGACATTGAAATTCTCAAAGAGTGCATTAATTCCGCCATGCCTTCCAGGTTTAAGAAGGTAAGGTCCACTGTGATACCCAGTCTCTCAAACCAAGTAATCAACATGCAGGCTCGAAAATCTGTGCCAGTTTATATGGTGCTGCAGAACAAAAACAATCAAATGTGTACTGGACAAAAGCTTGGAATGTCTTCGAAAGAAATCTATCATGATGATTCCTCTTACACAGACTCTGCCGAAGGTACACCCATCAATTTCTCAAGCACCACTTCCTTGAGTGATGAAACTCTTCAATATCCAGCCAGAACTAAAGGCATGAAAGACTGGCGAAGAAACAAAGAGACACAAGAGCTTGTTGATATCGAGGCAAAGAGAATTGAAGACCTACGCATGTTCTCTCGCTTCCACAAACCAACTAAAATAGCATGTCAGTCTCACCTAGTCACGAATCAACTGAACAAAACGATCAGAAGAATGGTTCCCACTCAGAGATTACTAATACAAAGTAAAGAGATGGCAGCAAAAATGACCCAGCAACGAATTCAAAGCCAGTCTCCAGTTAGACAAATTCAAAAGCAAGGACAGAATCTGTCAAGAAGCATGCCACAGTTGGATTTTCCCATGAGAAAACAAAGCACTGAGGTGTACCAAAATCAGAAAACCTGCTATCTAAGTCATGTGCAGGAAAACACTCTATCCCTAAAGTCGAGGCGTCATCCATCATCTACAGAAGGCATTTGTCATAAAATGGAAAGGCATGATGGACAGATGAATAGGACTGGACGGAAACAACAATATGATTCAAGCAATATAATACGTAATGCTAACATACAAGATCAAGTCAACAGTTATCAGTCCCGCCAAAATGGTTTTCacagaatcaaacaaaatctaatTTTAGAAGAAGCACCTCCATGCTACTCTTTGAGTTCCTCTCTTAGTTCTTTAAGTGATGCTGAATTTGAGGAACATGAAAATCCTCAACATACGTGGATAAAGAATAGACATAACATAATGTCCAACCTTCAGTGCCATCCAAAGTCACAGAAAGACCTCAACCAGTTTGAAGAGAACAGCTCGCCTAGTTCAGTCAGCATGGATTCAGAAGATGATCTTTTGATAAAATGCATAACATCTGCTATGCCACAACACAAGAAAAGGCAAGCTGCCCGAAAACGAAAAGCTGAgaaaaagcacaaacaaaaagcTACTCTTCAGAAAGCAGCAGAGGACAGGGGTCTTGATAATGACCTAGATAGTGATGAAATGGCATCAGACAAGGACTCTGATCTCAATAGTGTTGAATGGAGAGCAATACAAGAAGGAGCGAATACAATCATAACCAAGTTACAAGCTTCAAAGTCCCAGGAACCCTCATCAGAGTCTGAGTCAGTTTTGTCATTTATGTCTGGCTCAAGCTTTACTCCTAAAGAGAAGAAAGTATACAAAGATGACAAAAAGGCTAATAAACCGCTTGATTTTGCCCCTCGTAAACCTGTACCAAACTTCCCTGTGGTCTTCAGGGGTAGAACAGTGATATACACACCCAAAAAGGAGACAACACTCTCTCAGAGACCACCACCTAAAAAGGTGTCACCGAAAGCAGATGCCCCTAAAAATCCAAATCTAGCTCAACATAGGTCAAGAAGCCTTCACAGACTGGGCCAACCCATGGAGTCCACTCAATTGTCTTTGCCCAAAAGAAGCTCAACGCCACCTGCCAGGATACCGAAGAGCTCATCATCAGGATCATCACAAAGCTCAACACCATCCAGGCAACCTCAGAAAAAAGTAACCTCCCAGCCTCCCATAAAAGGAACAGAGAAGGTGGCATCAGCACCATCCAGCCCGCCAGACAGAAGAGGAAGAAATTCAAACATTGATCAAAACTCTAAATCCCCTATAGACAGGAAAACACAGAAATCTCCTGTCAGAATACCATTCATGCAGAATCCATCAAGGCAAACCAGAAACATTTCACCTTTAGTAACCAACCAGCCCACTAGCATCAGCAGACAAAATACGCAGAT

Function

symbol description
apc2 Predicted to enable beta-catenin binding activity; gamma-catenin binding activity; and microtubule binding activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of microtubule depolymerization; and positive regulation of protein catabolic process. Predicted to act upstream of or within Wnt signaling pathway and negative regulation of Wnt signaling pathway. Predicted to be part of beta-catenin destruction complex and catenin complex. Predicted to colocalize with cytoplasmic microtubule. Human ortholog(s) of this gene implicated in Sotos syndrome 3 and complex cortical dysplasia with other brain malformations. Orthologous to human APC2 (APC regulator of WNT signaling pathway 2).

GO:

id name namespace
GO:0001708 cell fate specification biological_process
GO:0045732 positive regulation of protein catabolic process biological_process
GO:0016477 cell migration biological_process
GO:0030178 negative regulation of Wnt signaling pathway biological_process
GO:0090090 negative regulation of canonical Wnt signaling pathway biological_process
GO:0007026 negative regulation of microtubule depolymerization biological_process
GO:0045595 regulation of cell differentiation biological_process
GO:0007389 pattern specification process biological_process
GO:0007399 nervous system development biological_process
GO:0016055 Wnt signaling pathway biological_process
GO:0005881 cytoplasmic microtubule cellular_component
GO:0030877 beta-catenin destruction complex cellular_component
GO:0016342 catenin complex cellular_component
GO:0008013 beta-catenin binding molecular_function
GO:0008017 microtubule binding molecular_function
GO:0045295 gamma-catenin binding molecular_function

KEGG:

id description
ko04120 Ubiquitin mediated proteolysis
ko04110 Cell cycle
ko04111 Cell cycle - yeast
ko04113 Meiosis - yeast
ko04114 Oocyte meiosis
ko04914 Progesterone-mediated oocyte maturation
ko05166 Human T-cell leukemia virus 1 infection
ko04121 Ubiquitin system
ko03036 Chromosome and associated proteins

ZFIN:

id description
ZDB-GENE-090422-1 Predicted to enable beta-catenin binding activity; gamma-catenin binding activity; and microtubule binding activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of microtubule depolymerization; and positive regulation of protein catabolic process. Predicted to act upstream of or within Wnt signaling pathway and negative regulation of Wnt signaling pathway. Predicted to be part of beta-catenin destruction complex and catenin complex. Predicted to colocalize with cytoplasmic microtubule. Human ortholog(s) of this gene implicated in Sotos syndrome 3 and complex cortical dysplasia with other brain malformations. Orthologous to human APC2 (APC regulator of WNT signaling pathway 2).

Ensembl:

ensembl_id ENSDARG00000063007

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00007482 True 6450 mRNA 0.46 15 7281240 7320211

Neighbor

gene id symbol gene type direction distance location
XLOC_003906 zgc:113223 coding downstream 19523 7253077 ~ 7261717 (-)
XLOC_003905 smim7 coding downstream 124547 7151579 ~ 7156693 (-)
XLOC_003903 bmp7a coding downstream 133700 7107798 ~ 7147540 (-)
XLOC_003904 CR925817.2 coding downstream 164877 7116247 ~ 7116363 (-)
XLOC_003902 si:ch211-253b8.5 coding downstream 202765 7039259 ~ 7078475 (-)
XLOC_003908 NA coding upstream 25589 7345800 ~ 7349497 (-)
XLOC_003909 si:dkey-197i20.6 coding upstream 30715 7350926 ~ 7355995 (-)
XLOC_003910 vtg3 coding upstream 39285 7359496 ~ 7380688 (-)
XLOC_003911 adgrl4 coding upstream 62966 7383177 ~ 7411436 (-)
XLOC_003912 NA coding upstream 453621 7773832 ~ 7796332 (-)
XLOC_003938 BX324177.10 misc upstream 4018593 11338804 ~ 11339100 (-)
XLOC_003942 BX324177.17 misc upstream 4047383 11367594 ~ 11367890 (-)
XLOC_003943 BX324177.3 misc upstream 4050244 11370455 ~ 11370653 (-)
XLOC_003944 BX324177.4 misc upstream 4060693 11380904 ~ 11381204 (-)
XLOC_003945 BX324177.6 misc upstream 4063622 11383833 ~ 11384130 (-)
XLOC_003895 NA non-coding downstream 481302 6792546 ~ 6799938 (-)
XLOC_003894 BX936438.1 non-coding downstream 499164 6780708 ~ 6782076 (-)
XLOC_003893 NA non-coding downstream 824940 6455034 ~ 6456300 (-)
XLOC_003891 NA non-coding downstream 849892 6429973 ~ 6431348 (-)
XLOC_003920 CR847563.2 non-coding upstream 1156750 8476961 ~ 8515750 (-)
XLOC_003922 NA non-coding upstream 1663440 8983651 ~ 9523184 (-)
XLOC_003923 CR788237.2 non-coding upstream 1965612 9285823 ~ 9286476 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000058_00599524_00634109 APC2 coding CI01000058 null 599179 ~ 634109 (-)