XLOC_005686 (pcsk2)


Basic Information

Item Value
gene id XLOC_005686
gene name pcsk2
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007124.7
NCBI id CM002897.2
chromosome length 52186027
location 912123 ~ 977652 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00011291
ATGCGCCGGTTCCGCGGACATCACCGGACGGCTCCTGCGCTGTTTCTGACTCTGATCGGTGCGTTAATGATGTCCGCTGCAGCCGAGGACGAGCTCTTTATCACCGGGCATTTTCTGGTCCAGATGCGGGAAGCGGCGCCTGAAGATGCCCAGAAACTCGCGCTGGAGCACGGCTTCGAGAGTGCGAGGAAGcttcCATTCGGCGAGGATCTTTTTCATTTCTACCCACTGGAAATGCCTAAAACCAGAAGAAAACGCAGCCTCCACCAACAACACCACCGCCTGGCATCAGACCACCGGGTGAAAAACGTGTTTCCTCAGGAAGGTTTCGGCCGTCAGAAGCGAGGCTACAGAGATCTCCCAAACACTGACGTCAACATGAGCGACCCGCTTTTCACCAAACAGTGGTATCTTATAAACACAGGTCAGGCTGACGGGACCCCGGGGCTGGATCTGAATGTGGCCGAGGCCTGGAGTTTGGGGTTCACCGGGAAAGGAGTGACCATCGCCATTATGGATGATGGTATTGATTATCTGCATCCAGATCTCGCCTCAAACTACAACGCAGAAGCCAGCTTCGACTTTAGTAGCAACGACCCATACCCTTACCCGCGCTACACCGACGACTGGTTTAACAGTCATGGTACCCGGTGTGCTGGCGAAGTGTCTGCCGTTTCCAACAACAACATCTGTGGGGTGGGCGTGGCCTACAACTCCAAGGTAGCAGGAATTCGTATGCTAGACCAGCCCTTCATGACAGACATCATCGAGGCATCCTCCATCAGCCACATGCCACAGGTTATTGACATCTACAGTGCCAGCTGGGGTCCCACCGATGACGGAAAAACGGTGGATGGCCCCCGGGAGCTCACCCTGCAGGCCATGGCCGACGGAGTCAACAAGggtCGTGGTGGGAAAGGCAGCATCTACGTTTGGGCTTCTGGAGACGGCGGCAGCTATGATGACTGTAACTGTGATGGATACGCCTCCAGCATGTGGACCATATCCATCAACTCGGCCATCAATGATGGACGCACGGCGCTCTATGATGAGAGCTGCTCCTCCACCCTCGCCTCCACCTTCAGCAACGGCCGCAAGAGAAACCCTGAAGCTGGCGtggcCACCACGGATCTGTATGGAAACTGCACGCTGCGTCACTCGGGCACATCTGCTGCGGCTCCTGAGGCTGCTGGCGTGTTTGCATTGGCGTTGGAGGCCAATCCCAACCTGACGTGGAGAGACCTGCAGCACCTGACGGTTCTGACCTCCAAGAGGAATAAACTGCACGACGAGGTTCACCAGTGGCGGAGGAACGGCGTGGGTCTGGAGTTCAACCATCTGTTCGGGTACGGTGTGCTGGATGCTGGTGGAATGGTCAAACTCGCCCGCGACTGGAAAACTGTGCCTGAACGATTCCACTGTGTGGCCGGATCCATGCAGGACATTCATAAAATACAGTCCGGCAACAAGCTCCTGCTGAGCATCAGCACCGACGCCTGCCAGGGCAAAGACAACTTTGTGCGGTACCTGGAGCACGTGCAGGCGGTCATCACAGTGAACGCCAGTCGGCGTGGAGACCTCAACATCAACATGACCTCACCCATGGGTACCAAATCCATCCTGCTGAGCCGCCGGCCCCGAGACGACGACGCCAAAGTGGGCTTCGATAAGTGGCCCTTCATGACCACACACACCTGGGGCGAGGACCCGCGGGGCCCCTGGCTCCTGGAGGTGGGTTTCCAGAGCCAGAGCGACATGCAAAGCGGCCTGCTGAAAGAGTGGACCCTCATGCTGCACGGTACACAAAGTGCCCCTTACATAGACCAAGTGGTGCGGGACTATCAGTCCAAACTGGCCATGTCCAAaaaagaggagctggaggaggagcTGGACGAAGCCGTGGAGAGAAGCTTGAAGAGCCTTTTGAGTAAAAATAACTAG

Function

symbol description
pcsk2 Predicted to enable serine-type endopeptidase activity. Predicted to be involved in peptide hormone processing. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space; membrane; and neuron projection. Is expressed in several structures, including digestive system; heart; integument; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2).

GO:

id name namespace
GO:0016485 protein processing biological_process
GO:0016486 peptide hormone processing biological_process
GO:0006508 proteolysis biological_process
GO:0043005 neuron projection cellular_component
GO:0005615 extracellular space cellular_component
GO:0016020 membrane cellular_component
GO:0004252 serine-type endopeptidase activity molecular_function
GO:0016787 hydrolase activity molecular_function
GO:0008233 peptidase activity molecular_function
GO:0008236 serine-type peptidase activity molecular_function

KEGG:

id description
ko01002 Peptidases and inhibitors
ko03110 Chaperones and folding catalysts

ZFIN:

id description
ZDB-GENE-090608-1 Predicted to enable serine-type endopeptidase activity. Predicted to be involved in peptide hormone processing. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space; membrane; and neuron projection. Is expressed in several structures, including digestive system; heart; integument; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2).

Ensembl:

ensembl_id ENSDARG00000019451

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00011291 True 1941 mRNA 0.57 12 912123 977652

Neighbor

gene id symbol gene type direction distance location
XLOC_005685 NA coding upstream 50227 859057 ~ 861896 (+)
XLOC_005684 gsta.1 coding upstream 59617 844143 ~ 852506 (+)
XLOC_005683 AL929536.3 coding upstream 71336 835390 ~ 840787 (+)
XLOC_005682 gsta.2 coding upstream 79792 829585 ~ 832331 (+)
XLOC_005681 nrxn1b coding upstream 100847 733027 ~ 811276 (+)
XLOC_005688 prokr1b coding downstream 38097 1015749 ~ 1025224 (+)
XLOC_005689 cnrip1b coding downstream 112290 1089942 ~ 1097017 (+)
XLOC_005690 ppp3r1a coding downstream 122545 1100197 ~ 1120773 (+)
XLOC_005691 wdr92 coding downstream 154096 1131748 ~ 1141171 (+)
XLOC_005692 perp coding downstream 177884 1155536 ~ 1170695 (+)
XLOC_005671 NA non-coding upstream 207785 471548 ~ 704338 (+)
XLOC_005675 NA non-coding upstream 351138 553591 ~ 560985 (+)
XLOC_005670 CABZ01061569.1 non-coding upstream 473661 438347 ~ 438462 (+)
XLOC_005661 NA non-coding upstream 642806 268042 ~ 269317 (+)
XLOC_005701 CABZ01044297.1 non-coding downstream 787855 1765507 ~ 1765622 (+)
XLOC_005705 NA non-coding downstream 1005659 1983311 ~ 2033043 (+)
XLOC_005706 NA non-coding downstream 1172118 2149770 ~ 2153016 (+)
XLOC_005708 CR376766.2 non-coding downstream 1374637 2352289 ~ 2352995 (+)
XLOC_005710 CR376766.1 non-coding downstream 1408761 2386413 ~ 2386533 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000005_06199038_06247505 PCSK2, PCSK2.L, MGC84034 coding CI01000005 null 6199038 ~ 6247505 (-)
bowfin (Amia calva) AMCG00001633 pcsk2,LOC107699156,LOC106607177 coding CM030143.1 CM030143.1 10014223 ~ 10050694 (+)