XLOC_006432 (epas1b)


Basic Information

Item Value
gene id XLOC_006432
gene name epas1b
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007124.7
NCBI id CM002897.2
chromosome length 52186027
location 8375612 ~ 8446341 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00012456
CGCCCTTCAGTGAGGCTCTGCGGTCTGTGAACTTCACTGACCGCAAAACAAGCGAGTTACTCCCTCACCGCGACGAGCCTCACCGCGCTTGGATTTTACAAAAGTGGGAGACTGTACAATCCTCAGCAGTGTTCTGAGACTGTACAGTCGCTTTTGCCTTAGTGGACTTTACAGCAATTTCACGTTCAGCTGTGCGTCGTTCACTTTAACGCGTGTTTGCGGTGGTTTGGTGCGTGTCTTTGCACGGAGAGCTGGTCCTGTTGCACTGCGGGAATTACGCGAGAACGGCGCGATGACAGCTGAGAAAGAGAAGAAGAGGTGCAGCTCAGAGCGGCGTAAGGAGAAATCTCGTGATGCCGCGCGCTGCAGACGGAGTAAAGAGACAGAGGTGTTTTATGAACTGGCTCATCATCTTCCCCTTCCACACAGCATCAGCTCACATTTGGATAAAGCGTCCATCATGAGACTGGCTATCAGCTTCCTGCGGACACGCAAACTCGTCAACTCAGGCTACAATACTCCCACTGAAATGACAGATGCAGACAGACTCATGGACAGTTGGTATCTGAAGTCACTCGGTGGCTTTATTACAGTGGTAACATCAGATGGAGACATGATCTTCTTATCGGAGAACATCAACAAATTCATGGGTCTCACTCAGGTGGAGCTAACAGGACACAGCATCTTCGACTTCACTCATCCCTGTGACCATGAAGAGATCCGCGAGAACCTCAGCCTCAAAGCCGGCATTGGAAAGAAAGGCAAGGAGTTGAGCACAGAGAGGGATTTCTTCATGAGAATGAAATGCACAGTCACGAATCGAGGGCGCACCGTCAATCTTAAGTCAGCCAGCTGGAAGGTTCTACACTGCACGGGTCATCTAAAGGTGTGTAACGGCTGCCCAGCACGAGTTCTGTGTGGTTTTAAGGAGCCGCCGCTCACTTGTGTGGTCATGATGTGCGAACCTATTGTCCATCCATCAAACATCGACACACCGCTCGACAGCAAGACATTTCTGAGTCGCCACAGCATGGACATGAAGTATACTTACTGTGATGAAAGGGTTACAGAGTTGATGGGCTACAATCCTGAAGATCTTCTCGGACGATCTGCGTATGAGTTCTACCATGCTCTGGATGCTGAAAATGTCACCAAAAGCCACCAGAACCTGTGCACTAAAGGCCAGGCAGTGAGTGGTCAGTACAGGATGTTGGCCAAGAATGGGGGCTATGTGTGGGTGGAGACCCGGGGTACCGTCATCTACAACAGCCGCAACTCCCAGCCCCAGTGCATTGTGTGCGTGAACTACGTGCTGAGTGACGTTGAGGAGAAATCCTTGATCTTTTCCATGGACCAGACTGAGTCTCTGTTCAAGCCTCACAAGTTGAATGGTTTCTTCAGTCCAAAAGAAGCCCTGGGCAGCGATCCAGCTGATTTGCTCTTCACCAAACTGAAAGAGGAGCCTGAAGATCTCACGCAGCTGGCACCTACACCTGGGGACACCATCATCTCTCTTGACTTTGGTCAGTCTCAGTATGAGGAGCACACAGTGTACAACAAAGTATCTTCAGTTGCACAGACTGTCTCTCACCCTGTTCATGATGGCCACAGGACAAGCTACTCTGGAGAAATGGCCAAGATGGCCGCCACTTTCTCTGTGCCTCAATCTGCACCTCCAAGTAGTGCAACTCCCAGCCTAAGCAGCTGCTCTACGcccagcagcCCAGATGATTACTACACCCCTGTAGACAGTGACCTAAAGGTTGAATTGACAGAGAAACTGTTTTCCTTGGACACGCAAGAGGCAAAGACTTCCCGCAACCAAGAGACTGACTTGAGTGATCTGGACTTGGAGACACTGGCTCCCTATATCCCCATGGATGGTGAGGATTTCCAGCTCAATCCCATCTGTCCGGAAGAGCCGCCATCTGAGATTGGAACCCTGGGAACCAACCAGCAGTGCTTCAGCAACATCACAAGCCTCTTCCAACCCTTGAGTTCACCTTCAGCAGCTCATTACCAGCCCAAAATGAGTTCAGGAGGGGACAAGCAGAACATCAATGGAGGCTCTGTGGAGTCATGGCCACCTGTTCCTTACAGCAGGGATCCCATGCAGATGCCTCCATACCATGATCCCGCCAGCACACCGCTGTCCTCAATGGGAGGGCGTCAGAATCTCCAATGGCCGCCCGACCCTCCTTTACCCAGCAAGGCTGGAATGATGGATCCTTTAGCTGCAAAGCGCTCTTGCCAAGGCATGCCAGCAAATCGAATGGCACCTTTTATGCAAAGGCCTATGGAGAACTTTGTGCAGAACTACAGAGATACAAGTCCAGCTCGACTTGCTCTTGCTAACAGTTTCAAACGCTCATTCTCACAGATGGCCATGGCAGAGACACCACCTACTAAGTCTCAACAGACAGTGTGGAAGAAACTTCGGCATGAGAGCTGTGCAGTCATGGAAAGGAAATCACTCAGCAGTAGCGCATTGTCAGATAAAAGCATGGCCCATAATGGAGGCATGGACCACCAGCACAGGAAGAGCCAGTACTCGGGTAATCAGAACGGACAACCGACAAAACACTACCGAGAACAGTTCTGTAACTACAGAGAGTTCAACATGCAGCCTTCCTCCAAAATGGATGGAATCGCGAGCCGTCTTATCGGGCCCTCCTTCGAGACCTACTCACTGCCTGAACTGACGCGTTACGACTGCGAGGTCAATGTCCCGTTGCAAGGCAATCTTCATTTGCTGCAGGGCAGTGACCTCCTAAGAGCATTAGACCAGGCGACTTAGACCGTTTTCTACACTAGCACACAGAAATGCAGTCCGGCTTTACTGACCCGTTCATTCATCTCACTGTCACCAACCTGACGATAACTATCCCAGCTTTAACACACTTCTAGGCAGGCTTGTGTATAAACCCGCTCACGGTCGCATCACAGTCATGACTGCATGACAAATGTAGCTTTGATTTTATCTGTATTGTCTACATCTTCATAAATTATATACATGTACTATTTTTTTAGTTGCAAGTAAGTTGATGAACTTAAGTATTTTTGGAGGAGTTTAAATGTTGCGTTGTCGTTTTTGGCCGGCTGTCTCTCTGCTTGACGGATAATTTTGCTGAAACTGTTTTCAACATGTTCTACTCTAGTCGGTTTCTCTATCAACatcagacaaaaaaagaaaaaaagagagagagagagaaagtaaaaagaaaagaatcTACTGTAAGctacttgtttttaaatgttctaatttctttcatttgttctaACTTTCCTACCTCTGACATGTTATTAAAGACCCCCTGAAATCAAAATGTTTTGAACCTCCCTTGGAATCCAAGGCGAAatttaaatcactttaaatatCCTGTAACACTTGACTAATCAGCATTAACATTAGCTATTCTTCAATCTGCATACTTCAACTCAAGCcccttaaaaatgtaatataataagcATGACATGGTAAAATCATACCAGGAAAAAAACAGGAATTACCAGTATTCTGTTAAATTAGAGGACAGGAACTGTttatgaaaatatgaatttatttggAATGAAATCTTTatcaatgttattaaataaaaacaggtgcttcagtggttagcactttcaccccacatcaagaaggtcgctggttcgagtccgaACTAGACAgggtgacatttctgtgtggagtttgcatgttctcctcgtctgtgtgagtttcctccgggtgctccggtttcccccacagtccaaagacatgcgctgtaattgaattgggtaaacaaaaatggtcatagtatgagtgtgaataggtgttttttagtactgggttgcagctggaagggcatccgctgcgtaaaaaatatggtGGATAATataggtgtgaacctacactggtctcacggttcgattCTGactatcatgccatcaattcggttTAAATTAATATCATCACAGTTCatcgacgatgctttccatacatatttatatttttttctttacaacacaacacaaaaactgtactaaaatctataaatatatttcaagagttcacacttagatagtgcttgactatttaagctagtttggcatgctgtcccgggagagaaccctgagctcggtgatagatgagcccaaggctcccgcctggtcaataagcattaggagagatatgagatcaggtagttctcgatagctcCCAAAATAAATCACTATTGGCGCTAATTTGTAGTatgtgcttgtgactttaactttgcatgttttttttgggGTGTGGGAGGAAATCggagtacccggagaaaacccacgcgaacacggggagaacatgcaaactccgcacagagagtatcggttggctcagctagtgttgaaccaatgacctccttgctgtgaggcaacagtgctagccaccgaGCCGCCGTGACGTccggaggagggagaagggaaggATGGGGGGGGTTTccaaaaacgaagatgaggaatgaagtttaggctggatatttatattgaatttagagtgatccgattggctagttagtgattagtgataaggatcagctgtagtcaattctatcacgtgctcctctcgaaattagtttgggaaacttcactaatatttttatattatttgcaatACAATTGTCTCACGTAATTCAAGCAGTAACATATATAAACTGTATCTTTACTTGACtcgctcaaagaaaacactctttttgaatgttttaaataaaactcaAATACATCCATaaaagacagcatgagcatttatagcacataaactaatgtaaatattatcctgctTGCTTTTCGAGCAGTCAAGCGATTTcctacacccctatgattggtcattgtcACCACTttctcaacagaaagggctgcgattggctttaaaaatgaaagcgctgttcacTGATGAGTGACACTTGTAGAACAGCCACGGTTACAGTCTATATGTGCATAATgcgcggttatcacaggtaatccataatTGACGCAGTGGAGAAGGAAAAGTTACCTCTTGATcacgccagcgggtcaaatgtccaaagagagagagagagagagaggggcagGGATGGGGTTTTACAGCATCTCTCACTAGTAGTGAAATAGCTGCTTATGCTGTACCTTCTtcaatgtcagtgaaagactgtccagcaaactcacaagcagtgaatcGAGCACAATTATCTGCTTTTTAATAAGTAATAGGAGCATTTTACTTACTCGCCCTCGCCCACTTCGCCATAGTATTCATCACTCATAGGAGATAAATAACATCAGTGCGTAAttaccggttatgatctattactgaatcgataccgaattgtccgcatctgcatcacggtgcacagaggaaacaattaattttgacacccctactggataagttggtggttcactccgcagtggcaacccctgacaaatcagggactaagccaaattaataggaataaatgaaataaacaaaacacataaGCTTAATTATGCTTTggtaaattacactttaaataaGGGGTCTTCAAAGACAAAGGTTGAGAACTGCTGTGCTAGTGTAATTAAAGATAACGCATTCTGTGTACTTCAAAATGAGGGTCTCGATTCGTCCCTCGAGTTGCATTTTCCCTGCAGAAGCCAGCTTTAatcactaataaataataataataataattcttgcTGGTTAGAATCTAGTTTTCCTGAAGAAATAGCTTATCCTGTCCTTGTGTGTTAGATTAGAGGTAGAGCTCAAGGCCAGGGTTTTTAAAACGTGCCAACCTTTTCATTTGTGCCCAATCAGATTTCAATATGATGAATGCCGTCTACTAGTAATTTACAAGTTAAGGTTGTGGTGTGGTTAAAGGCTATTTCatattaaaaacagtaataatccTTCAGTATTTCTGACTAAAACCGCCAAAAACGAAAATAAAATTGCTCCCATAAGCCATTTCATGGGGTCTTTATGATTTGTCCTCACTGACCACTTTCAGTGTTTGCTCTTCATGTGCCTTCCTCTGTTCAAATAGTGGCAATACTGTGTTTCTGTCTCTGTTTATTGCCTTATTGTGGAGACcactttaaaatacatatatatatattttcgatTTAGctgtaaacataaatatttaaaggaaGATGCTCTACTATAGATTTCTACTACGATGATAAagttaatcatttatttgttctGGTACTTTGTCTTGTCTACTCTGTAGATGTGAATCAGAGTCCTTCTAGAGTCTGCAGTGCTGGTGTCCTGTGTTCTTTCTTggtggcattttttttttctgcaaaaccTGTATGCGTATTACATTTATTGGCAGGCCAGTACAGTTGGGTATAAAATTAAACTTCCTTTTTTTTAagctaaagaaagaaaaatctgtttTAGACATCTTATGTAGCATATCAGATCCTTGAAATGAGTTTAAAATCTTAGTGGTTTCTTGTATTGTTTGGTGCTTTTATGCAATTTGACCCATATGCATACTTAAGTAAATAACATTAACTCTTTTTATTTGAATTACCCAATGGTTGTCTTTAAAGTTGAATCATAAAGCATCCAGCTGATTTAATACGATATGATTGCTGTAATATGCACTAATGTAGCAAGAACTATGTTGTTGGTTCTTTTTTAGCTGAAAGACATTTGCATAGAATAttcttttattacatttttaagccCCTGGtggaaaaaaagtgatttaaagtAATGGTACAAGGTACAAAGAAAAGGTTTAGCACACAATCCAGTTTTTAAACTGACTTTTGTGCACAGGCTGGATTTGTGTTGCTTTATGTTGGATTAGCTGTGTGAGACTATTGCTCAGACTGAGAGAGTGGCTATGCACAACTAAGTAAAGCTTATGTGTATATAAAGATATATGTGATTTTagttgatgataataattatctTTATTGCTGTCGTTCCCCAAATCCCtcctatttttgtattatttaaaaacaaaacaaataaattatccCTACTGTGACGTGGAAAAAGAAGTCATTAGCTATTTATAAAAttcagaatttatttttttaagtgttttagtagtATGTTTTAAAAGCTTTAACTTATCCTGTTTTAACAAGTATCATTGAGATTAATGAAAGTAACCAAAAACGTGGTAATGTTGTGCTAAATTGtcacaatgcaaaataaaatttaatcatatataaaaaaaacctcattaaatataatttctttaattatttagcttttattattttagggtaccttttttaacctttattagagTATTTATCTGAAACATGCACTAAagcaaagactctagaatacacaagacgtgtcactcgtatctGTTTGAACGGGGAAGAGTGTAATTGTTAACATGGTGAATAAAGctccgcctactagtacaggagccaatcatcgatcgctctATAGTGAAAAAAGCCCACCtgctagtacaggagccaatcatcgatcgctatatggtgaaaaAAGCCCGCCTtccagtacaggagccaatcatcgatcactatagactgacgATACTCTGAGAGAGGGGCTTGGACCTGATGTGAgcttctgcagattttgtgtgattcgaacatttagaaatgaaactaaagagacagctgttgttttattttattattgattccTCATTTgaaatttaatcataagcttggcaagcaagtTTGGAAAAtgtgatgtttccccattcaaacataaTACCCGAGCAAACTgcctgagaggtgtttcaaagatggccgccaaatGACTTCCCTCAAAGGGACTTTGACTAAAGTTAGCAGTAGCATCTCATGTTATAACCTGTCAGAAGCGTAAACTCCTTGTACAACTCAGGTGTCAACCTAGATTTGACAAACGTTTTACTGCTCAAGATAATAagtacagatatatagacagacagcaGGTGTCCGAGCTGTGagggacagacagagagataacATGCAGATCTCTTATCTTGGATAAGATTCCAATGTGTTTTGGGTGAAAGTCAGTGTATTTCCCCAAGTATACCAGATGCATGAACGGTCTTTCATGCCTGGATCAAGGAACTTTACATATTCTCCTATTCAAACTGTTACAGGTGCCTTAACCCATGCAAATGTAGATTAGTTGTTCAAAGCTAAGTCTTTAAGCAATGCAGTATTCCCATTCCTAGAATATTCAGATATGAATGCCAAAGGAGAAAAGTGCAGCCATGAAAAGGAGATTTTACATTGAGAATTTGAATGTGCAGAGAGCGCTTGTTCATGTATGGCTTATATTTACTATTATGAAGGTCATTCACCTGACCGAGACCCCCTAAACCCACCAGCATTGTTTTCAAATGATACCACCCTTCATGCACCCAAttggtttagtttttttcttcaaCTTTAAAGACAACATTAGGATGCTGATACATAAAATAGACAGTTTCCTATATAATAAAGTAAGTACGtacatattttaatatgttaaatgTATATTGACATTATAATGATactgttattatgattattgttgaCATTACTGTATGGTAAATTTTACCCAGTAAGTTGTATCTCTGCACTGATATCTTATTAAAGCATATCAATCTTC

Function

symbol description
epas1b Enables transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including digestive system development; embryonic liver development; and hematopoietic stem cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; digestive system; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1).

GO:

id name namespace
GO:0051402 neuron apoptotic process biological_process
GO:0014823 response to activity biological_process
GO:0006355 regulation of transcription, DNA-templated biological_process
GO:0006357 regulation of transcription by RNA polymerase II biological_process
GO:1990402 embryonic liver development biological_process
GO:0031017 exocrine pancreas development biological_process
GO:0030182 neuron differentiation biological_process
GO:0048565 digestive tract development biological_process
GO:0097150 neuronal stem cell population maintenance biological_process
GO:0071456 cellular response to hypoxia biological_process
GO:0001666 response to hypoxia biological_process
GO:0043523 regulation of neuron apoptotic process biological_process
GO:0005634 nucleus cellular_component
GO:0000976 transcription regulatory region sequence-specific DNA binding molecular_function
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding molecular_function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function
GO:0046983 protein dimerization activity molecular_function

KEGG: NA

ZFIN:

id description
ZDB-GENE-060607-11 Enables transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including digestive system development; embryonic liver development; and hematopoietic stem cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; digestive system; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1).

Ensembl:

ensembl_id ENSDARG00000057671

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00012456 True 8581 mRNA 0.41 16 8375612 8446341

Neighbor

gene id symbol gene type direction distance location
XLOC_006431 dhx57 coding downstream 22052 8320455 ~ 8353560 (-)
XLOC_006430 atl2 coding downstream 71007 8281223 ~ 8304605 (-)
XLOC_006429 si:ch211-250c4.5 coding downstream 96079 8272043 ~ 8279533 (-)
XLOC_006428 NA coding downstream 145447 8168713 ~ 8230165 (-)
XLOC_006427 macroh2a2 coding downstream 608012 7753049 ~ 7767600 (-)
XLOC_006433 prkceb coding upstream 6013 8452354 ~ 8601184 (-)
XLOC_006434 BX004962.1 coding upstream 203370 8649711 ~ 8650051 (-)
XLOC_006435 BX004962.2 coding upstream 208778 8655119 ~ 8655447 (-)
XLOC_006436 mcfd2 coding upstream 235835 8682176 ~ 8692860 (-)
XLOC_006437 NA coding upstream 314353 8760694 ~ 8776477 (-)
XLOC_006338 rn7sk misc downstream 7549387 825904 ~ 826225 (-)
XLOC_006471 BX537274.2 misc upstream 1818400 10264741 ~ 10264905 (-)
XLOC_006426 NA non-coding downstream 626411 7747111 ~ 7749201 (-)
XLOC_006421 NA non-coding downstream 1052936 7269212 ~ 7322676 (-)
XLOC_006422 NA non-coding downstream 1058673 7305415 ~ 7316939 (-)
XLOC_006419 NA non-coding downstream 1220775 7154322 ~ 7154837 (-)
XLOC_006458 NA non-coding upstream 1055426 9501767 ~ 9558425 (-)
XLOC_006467 NA non-coding upstream 1630874 10077215 ~ 10118935 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000012_01412584_01433078 EPAS1B, EPAS1 coding CI01000012 null 1412584 ~ 1433078 (+)
bowfin (Amia calva) AMCG00001895 NA coding CM030143.1 CM030143.1 18830179 ~ 18850985 (+)