CI01000004_16037124_16044487 (MMP14, MMP14A, MMP14B, MT1-MMP)


Basic Information

Item Value
gene id CI01000004_16037124_16044487
gene name MMP14, MMP14A, MMP14B, MT1-MMP
gene type coding
species grasscarp (Ctenopharyngodon idella)
category of species economic fish

Chromosome Information

Item Value
chromosome id CI01000004
NCBI id null
chromosome length 17451736
location 16037124 ~ 16044563 (+)
genome version v1_2015/06_NatureGenetics_grasscarp_Genome

Sequence

>CI01000004_16037124_16044487.mRNA
GCATGGCTACAGCAATATGGTTATTTGCCACCTGGTGATCTCCGCACACATACGGCCCGCTCTCCTCACTCCGTCTCCTCTGCCATCGCTGCCATGCAGAGTTTCTATGGCCTGACAGTCACTGGCAACATGGATCCCGCTACTCTAGAGGCAATGAAGAAGCCCCGCTGTGGCGTCCCAGACAAGTTTGGAGCCGAACTGAAAAGCAACCTGAGAAAGAAGCGCTACGCAATCCAGGGACTGAAATGGGATAAACATGAGATCACATTCTGTATACAGAACTACACGCCAAAAGTTGGGGAATACGAGACGTTTGAGGCCATCAGAAAAGCTTTCAAAGTGTGGGAAAGCGTCACTCCTTTGAGATTCCGAGAGATCCCTTACAGTGACATCAGAGATAAGGTTGAAAATTTTGCCGACATCATGCTCTTCTTCGCCGATGGCTTCCATGGAGACGCCAGTCCGTTTGACGGTGAAGGAGGCTTCTTGGCCCATGCTTACTTCCCAGGCAATGGCATAGGAGGAGACACGCACTTCGATGCAGCAGAACCTTGGACCATCGGCAACCGTGACTTGTTGGGTAATGATGTGTTCCTGGTGGCTGTTCATGAACTGGGTCACGCCCTGGGAATGGAACATTCAAACGACCCGTCCGCCATCATGGCTCCCTTCTACCAGTGGATGGACACGGAGAACTTTGAGCTTCCTGAAGACGACCGTAAAGGGATTCAGCAGCTTTATGGACCAAACACGGGAGGACGCCCACGACCACCTGTCACCCCTCAGACCCCACATCATACTCCATATCCCACACCATACAGGCCCGGGGGACCTAGCTTTGGTCCTGACATCTGCGAGGGCCATTTTGACACCATTGGCATTTTTAGAGGAGAAATGTTTGTGTTTAAGGATAAGTGGTTCTGGCGCGTTCGTAATAATCGGGTTATGGAAAATTACCCCATGCCAATTGGACATTTCTGGAGAGGTCTGCCTACAGGTATCAATGCTGCCTACGAAAGAGAAGATGGGAAATTTGTCTTCTTTAAAGGGGACAGGCATTGGGTGTTCACCGAGTCGAATTTGGAGTCAGGTTACCCGAAGACTCTGAGAGAAATGGGTACAGGTCTTCCAAAGGACAAACTGGACGCAGCCCTCCTCTACACGCCTACTGGCTACACCTACTTCTTTAGAGGAAACAAATATTATCGTTACAATGAAGACACGCAGTCAGTGGATCCAGATTACCCCAAGCCTATGAGTAAATGGCAAGGCGTTCCAGACAACATAAAGGCTGCCTTCATGAGTCGAGATCAAAGTTACACCTACTTCTACAAAGCCAATAAGTACTGGAAGTTTAACAACCAGTTATTAAGAGTGGAGCCCGGATACCCCAAGTCTGCACTTAAAGACTGGATGGGCTGTCCTAATGAGGACTCCAATACAGGTGGCGGTGGTGGAGGAAGTGACCGTGATCGTGAAAGGGAACGTGAGCGTGAAAGGGAGCGTGAAAGGGAGCGTGAACGAGAGCGTGAACGGGAGCGTGGCCGTGACCGCACACACGAGGAAGACAAGACTGAGGAAGAGGGCAAAAAGGAGGAGACAGAGGTGATCATAATCGAGGTTGAAGACGCACCCAGCAGTGGAGCAGGAGCAGCTGCCGTCGTGGTGCCACTTATGTTGCTGTTCTGCGTGATCCTTACGCTCGGAGCACTTCTCTTCTTCCGCAGGTACGGCACACCGAGACGCTTGCTCTACTGCCAACGCTCCCTACTGGACAAGGTTTAAACGTTTAGGAAGGGATAATGGAAGAAAGGGAAGGGGAGGAGAGGAGAGAATTGAGAATATGGAAGAAGGGGACTTA

Function

symbol description
mmp14a Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Acts upstream of or within several processes, including gastrulation; retinal ganglion cell axon guidance; and skeletal system development. Predicted to be located in extracellular matrix and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including axis; head; head mesenchyme; mesoderm; and musculature system. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14).
mmp14b Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Acts upstream of or within several processes, including gastrulation; intramembranous ossification; and skeletal system development. Predicted to be located in extracellular matrix and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including axis; connective tissue cell; head; myoseptum; and tail bud. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14).
mmp14 Enables endopeptidase activity and metalloaminopeptidase activity. Involved in several processes, including endodermal cell differentiation; regulation of protein localization to plasma membrane; and zymogen activation. Located in several cellular components, including extracellular space; intermediate filament cytoskeleton; and macropinosome. Colocalizes with cytoplasm. Implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Biomarker of artery disease (multiple); breast carcinoma; diabetic angiopathy; dilated cardiomyopathy; and transitional cell carcinoma.

GO:

id name namespace
GO:0060026 convergent extension biological_process

KEGG:

id description
K07763 MMP14; matrix metalloproteinase-14 (membrane-inserted)

RNA

RNA id representative length rna type GC content exon number start site end site
CI01000004_16037124_16044487.mRNA True 1861 mRNA 0.51 9 16037124 16044563

Neighbor

gene id symbol gene type direction distance location
CI01000004_16017111_16024481 SALL2 coding upstream 12342 16016985 ~ 16024782 (+)
CI01000004_16008731_16013012 NA coding upstream 24075 16008615 ~ 16013049 (+)
CI01000004_15947153_15953245 NA coding upstream 83254 15947153 ~ 15953870 (+)
CI01000004_15930478_15944692 NA coding upstream 92380 15930478 ~ 15944744 (+)
CI01000004_15906907_15909647 HNRNPC coding upstream 127455 15906907 ~ 15909669 (+)
CI01000004_16090188_16090874 NA coding downstream 44863 16089426 ~ 16090928 (+)
CI01000004_16117960_16125599 DHRS1 coding downstream 73321 16117884 ~ 16125874 (+)
CI01000004_16138496_16143438 NA coding downstream 93933 16138496 ~ 16144117 (+)
CI01000004_16217935_16218580 NA coding downstream 173290 16217853 ~ 16218580 (+)
CI01000004_16221780_16232426 PSMB5 coding downstream 177217 16221780 ~ 16232940 (+)
G34229 NA non-coding upstream 17635 16019263 ~ 16019489 (+)
G34228 NA non-coding upstream 22018 16014906 ~ 16015106 (+)
G34216 NA non-coding upstream 108374 15928501 ~ 15928750 (+)
G34215 NA non-coding upstream 112628 15923704 ~ 15924496 (+)
G34214 NA non-coding upstream 116238 15920683 ~ 15920886 (+)
G33830 NA non-coding downstream 114149 16158712 ~ 16160998 (+)
G34266 NA non-coding downstream 135945 16180508 ~ 16180849 (+)
G34297 NA non-coding downstream 256670 16301233 ~ 16309306 (+)
G34322 NA non-coding downstream 404283 16448846 ~ 16449090 (+)
G34323 NA non-coding downstream 405117 16449680 ~ 16455626 (+)
G34220 NA other upstream 97174 15939357 ~ 15939950 (+)
CI01000004_15091390_15096502 GA45B, GADD45B, GADD45BB other upstream 945155 15091200 ~ 15097173 (+)
CI01000004_14036114_14036449 KIAA0040 other upstream 2000224 14035393 ~ 14039142 (+)
CI01000004_12646972_12652534 NA other upstream 3381413 12646838 ~ 12652570 (+)
G31865 NA other upstream 3841977 12192130 ~ 12197418 (+)
G33815 NA other downstream 18852 16063415 ~ 16066464 (+)
G34400 NA other downstream 932765 16971995 ~ 17025976 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
zebrafish (Danio rerio) XLOC_015747 mmp14b coding NC_007113.7 CM002886.2 38161318 ~ 38183641 (+)