XLOC_016324 (cyp7a1)


Basic Information

Item Value
gene id XLOC_016324
gene name cyp7a1
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007113.7
NCBI id CM002886.2
chromosome length 59640629
location 22150134 ~ 22152797 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00032168
GCATTTGTCTGTATCCTCAAAGAATACAGTCAAGCTCTACTTCCACCTGATTGTGTCTCACTAGCAGTCATGATCCTAACCATTTCCTTCATTTGGGCCATAGTGGTTGGTCTTTGCTGTTGTCTTTGGCTTATTACAGGAATACGCAGAAGACATCCTGCAGAGCCTCCATTAGAGAATGGCTGGATTCCCTTCCTTGGCTGTGCTCTTCAGTTTGGGGCAAATCCTTTAGAGTTTCTTCGCAGCAGACAGAAGAAGCATGGCCATATTTTTACATGCAAGATTGCTGGGCAGTATGTTCATTTCCTTTGTGATCCATTCTCCTACCATGCTGTCATCCGTCAAGGAAGGCACCTTGACTGGAAGAAATTTCACTTTGATGCCTCTGCGAAGGCATTTGGTCATGAGAGCATGGATCCCAGTCAAGGTTACACCACTGAGAATTTGCATCAGACTTTCCTGAAGACCCTGCAAGGGGATGCCTTGTCTTCTCTAATCGAGACCATGATGGAAAACCTCCAGGGCACCATGCTGCAATCTGGAATGTTGAAGGCCACAACCTCTGAATGGCAAAGTGATGGTATTTACGCCTTCTGCTACAAGGTCATGTTTGAAGCAGGCTACCTGACCCTCTTCGGAAAGGAACTGGATGGGGACCAGAGCATTGCACGTCAGCAGGCCCAAAAGGCTCTGGTGCTCAATgctttggacaactttaaagagTTCGATAAGATCTTCCCAGCTCTGATCGCTGGGCTCCCCATTCATGTTTTTAAGAGTGCCTACAGCGCTCGTGAGAAACTTGCCAAGACTATGCTCCATGAGAACCTCAGCAGGCGTGCCAATGTGTCTGATCTCATCTCCTTGCGCATGCTTTTGAACGACACACTATCTACCTTCAACGAGCTGAGCAAAGCCCGGACCCACGTCGCTATACTTTGGGCTTCACAAGCCAACACTCTGCCTGCAACCTTCTGGACTCTGTTCCACATGATCAGGTGCCCTGCGGCAATGAAGGCTGCAAGTGAGGAGGTGAGGCGAACCTTTGAAAGTTCTAATCAGAAAGTTGATCCTACAAATTCTCGGCTTGTACTGACAAGGGAGCAGTTGGACAACATGCCAGTTTTAGACAGCATCATTAAAGAGGCGATGAGACTGTCCAGTGCATCCCTTAATGTGAGAATGGCCAAGAGCGATTTCCTTCTTCAACTAGACAATAAGGAGTCTTACCACATTCGGAAAGATGATGTAATTGCTATGTACCCACCGATGATTCACTTTGATCCTGAAATTTATGATGATCCTTTGGAATTCAAGTATGATAGATACATTGATGAGAACGGGCAGGAAAAGACCACCTTTTACCGTAATGGGCGCAAGCTTCGTTACTACTACATGCCCTTTGGCTCTGGGGTGACCAAATGCCCAGGACGCTTCTTTGCGGTGCATGAAATCAAGCAGTTCTTGTCTTTGTTGCTATCGTACTTTGAGATGGAACTTTTGGACTCTGATGTGAAAGAACCGCCGTTGGACCAGTCTCGGGCTGGACTGGGTGTACTGCAGCCCACCTATGATGTTGACTTTCGTTACAGACTCAAATCTCTCTAAGTTTCTTGCTTGTATTTATTGACTGTTGGCTTGTActgtaaataatgtatatttttgaaaTTTCTTAGTAGACAATTGTAAATAGCCCTTGttgtcttttctttctttttaaagtgGATTTGGTAGAAATGTCTGGAAGTTTGAATGTCACTTTACGTTTTCAGTATCATTTACTGCACCTTTATTATGTGTATACACAGTATTTCTCATAGTTCTTAAATTATAGTGtagttttcattcttttatattgtAAATTGTTTAGGAAATGTAATAAACTACACGCATCTGTCACTGTCtgttaaacattttgtaaaataatgTGCTTTGTGATTGTACTGAACTTTATTTTCAAAGTACAGACTGAATTTTTTAAACCAAA

Function

symbol description
cyp7a1 Predicted to enable steroid hydroxylase activity. Predicted to be involved in bile acid biosynthetic process and cholesterol homeostasis. Predicted to act upstream of or within cellular response to glucose stimulus and cholesterol catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Is expressed in basal plate midbrain region; central nervous system; otic vesicle; and retinal ganglion cell layer. Orthologous to human CYP7A1 (cytochrome P450 family 7 subfamily A member 1).

GO:

id name namespace
GO:0006629 lipid metabolic process biological_process
GO:0071333 cellular response to glucose stimulus biological_process
GO:0008202 steroid metabolic process biological_process
GO:0008203 cholesterol metabolic process biological_process
GO:0006699 bile acid biosynthetic process biological_process
GO:0006707 cholesterol catabolic process biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0042632 cholesterol homeostasis biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral component of membrane cellular_component
GO:0008395 steroid hydroxylase activity molecular_function
GO:0008123 cholesterol 7-alpha-monooxygenase activity molecular_function
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function
GO:0004497 monooxygenase activity molecular_function
GO:0005506 iron ion binding molecular_function
GO:0046872 metal ion binding molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0020037 heme binding molecular_function

KEGG:

id description
ko00120 Primary bile acid biosynthesis
ko00140 Steroid hormone biosynthesis
ko03320 PPAR signaling pathway
ko04976 Bile secretion
ko04979 Cholesterol metabolism
ko00199 Cytochrome P450

ZFIN:

id description
ZDB-GENE-040426-1296 Predicted to enable steroid hydroxylase activity. Predicted to be involved in bile acid biosynthetic process and cholesterol homeostasis. Predicted to act upstream of or within cellular response to glucose stimulus and cholesterol catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Is expressed in basal plate midbrain region; central nervous system; otic vesicle; and retinal ganglion cell layer. Orthologous to human CYP7A1 (cytochrome P450 family 7 subfamily A member 1).

Ensembl:

ensembl_id ENSDARG00000069018

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00032168 True 1987 mRNA 0.43 6 22150134 22152797

Neighbor

gene id symbol gene type direction distance location
XLOC_016323 rab2a coding downstream 302199 21821683 ~ 21847935 (-)
XLOC_016322 chd7 coding downstream 329437 21765670 ~ 21820697 (-)
XLOC_016321 C2H7orf25 coding downstream 524641 21620177 ~ 21625493 (-)
XLOC_016320 ralab coding downstream 531505 21608352 ~ 21618629 (-)
XLOC_016319 NA coding downstream 557074 21571136 ~ 21593060 (-)
XLOC_016325 fam110b coding upstream 55607 22208404 ~ 22292414 (-)
XLOC_016326 NA coding upstream 112585 22265382 ~ 22268977 (-)
XLOC_016327 NA coding upstream 160954 22313751 ~ 22315063 (-)
XLOC_016328 NA coding upstream 188057 22340854 ~ 22348284 (-)
XLOC_016329 selenof coding upstream 200625 22353422 ~ 22363460 (-)
XLOC_016318 NA non-coding downstream 608091 21541606 ~ 21542043 (-)
XLOC_016316 NA non-coding downstream 766740 21381325 ~ 21383394 (-)
XLOC_016314 CU464125.1 non-coding downstream 829450 21312742 ~ 21320684 (-)
XLOC_016313 NA non-coding downstream 941575 21195528 ~ 21208559 (-)
XLOC_016330 NA non-coding upstream 236993 22389790 ~ 22409189 (-)
XLOC_016331 BX927330.1 non-coding upstream 281633 22434430 ~ 22434546 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000004_06651958_06654716 CYP7A1 coding CI01000004 null 6651869 ~ 6654928 (+)