XLOC_006807 (l2hgdh)


Basic Information

Item Value
gene id XLOC_006807
gene name l2hgdh
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007124.7
NCBI id CM002897.2
chromosome length 52186027
location 36666662 ~ 36680531 (-)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00013103
GCGAGTGTACGTCAGGGGCGGGTTCTCGAAGGACACATTCAGCGCCCTCGCGGAGACATTCCTTTACCCGAGAATAATAAACCGGACAGACCAGCAGTATGGTCACACGGTTATTATTACAAGTGTTTTAGGAAAAGTCCAGCTATGCTTTGTGGAATAATGATGAGAACTTTCGGTAGCGGGTCTGTGTGCGCGCGCTTACTGTCACAGAGAGCAAAGTCTGCAACATGCAGAGCTGCACATCACAGCGGCTCATTCGATGTGGCCATTATTGGTGGAGGGATTGTTGGATTGGCGTCCGCCAGAGAGCTGATCCTCAGGCACCCAAACCTCAGCTTTGCCCTGcttgagaaagagaaagagctgGCTCTCCATCAGACAGGTCATAACAGTGGTGTAATCCACACTGGGATTTACTACACTCCGGGCTCTCTGAAGGCTCAGCTCTGTGTCCGCGGAGCCACACTCGCTTATGAGTACTGCCAGAAAAAAGGGGTTCCGTATAACAGATGTGGCAAGCTTATCGTAGCAGTGGACAGAGAGGAGATTCCCCGTTTAAAAGCTCTATATGAGCGTGGTCAGAAAAACAATGTGCGAGATCTTCGACTGATTGACGCCAAAGCCATCAGAGAGAAAGAGCCGTATTGCAGGGGCATCATGGCATTGGACTCTCCATACACAGGCATTGTTGATTGGCGGGAAGTTGCTTTGGCGTATGGTAAGGACTTCCAGGAAGCAGGTGGCACCGTGATGACTGACTATGAGGCATCTGACATGAGTGTGGCAGCAGAGAGTCAAGCTGACAGCACTAATGGGCAGAAATACCCCATCATCATCAGAAGCTCTCAGGGCAAGGAGGTGCGCTGTGCTTTTGTGTTGGCGTGTGGTGGTCTCTACTCTGACCGCTTATCTGAAATGTCTGGCTGTAGTTCAGAGCCTCGTATCGTTCCTTTCAGAGGAGATTACCTGGTGCTCAAGCCAGAGAAAAATTACCTGGTCAGAGGCAACATCTACCCCGTGCCAAACCCACGATTCCCATTTCTCGGAGTTCATTTCACTCCTCGAATGGATGGAAGTGTCTGGCTAGGTCCAAACGCGGTGTTGGCTTTTAAACGAGAGGGATATAAACTCTTTGACTTCGACGCACAAGACTTCGTTAACGCACTCTCATTCAGTGGTCTGCAGAGACTGGTCATGAAGAATGTAGTGTATGGAGTTGGAGAGATATATAGAGGTGTGTTTCCTGGCGCTCAGGTGAAGATCCTGCAGAAATTCATACCCGAACTGAGCCCCAGTGATGTCATCAGgggGCCGTCAGGTGTCCGGGCACAAGCTTTGGATGCTGAAGGAAACCTGGTGGATGATTTTGTGTTTGACGGTGGGAAAGGAGAGCTGGGCAGTCGTGTTCTGCACGTACGTAATGCACCATCTCCTGCTGCAAGCTCATCTCTGGCCATCGCTGAGATGATCGCGGATGAGCTGGAGAAGAGATTTCAGCTGTAGACGCACCTCAGATGATCCTGCCTTCGTTactcttacacactcattcagagtGGAAAGCCGTCATTAGagcttttgttttttaacttttatagTGTTGGAGCAGTAATAATGCAACAGAATTCTGGTGCTCTTTTCTAATGTGTGTTTCTGGGAATTATGCTGATTTTTGGGAATGTTGTGTGTTTAAAAATATGATGATTTATTAGGAAAAAGCAATCACTGCCTTTATGTACAAAGGTAGTTGGGGTTCAGAGAATATTTTCACTCCATTACTggatttgtaaataataaaactaatacaaCTTC

Function

symbol description
l2hgdh Predicted to enable (S)-2-hydroxy-acid oxidase activity and 2-hydroxyglutarate dehydrogenase activity. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 2-hydroxyglutaric aciduria; L-2-hydroxyglutaric aciduria; cerebellar ataxia; hereditary spastic paraplegia; and visual epilepsy. Orthologous to human L2HGDH (L-2-hydroxyglutarate dehydrogenase).

GO:

id name namespace
GO:0055114 oxidation-reduction process biological_process
GO:0005739 mitochondrion cellular_component
GO:0016491 oxidoreductase activity molecular_function
GO:0003973 (S)-2-hydroxy-acid oxidase activity molecular_function
GO:0047545 2-hydroxyglutarate dehydrogenase activity molecular_function

KEGG:

id description
ko00650 Butanoate metabolism

ZFIN:

id description
ZDB-GENE-090319-6 Predicted to enable (S)-2-hydroxy-acid oxidase activity and 2-hydroxyglutarate dehydrogenase activity. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 2-hydroxyglutaric aciduria; L-2-hydroxyglutaric aciduria; cerebellar ataxia; hereditary spastic paraplegia; and visual epilepsy. Orthologous to human L2HGDH (L-2-hydroxyglutarate dehydrogenase).

Ensembl:

ensembl_id ENSDARG00000060500

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00013103 True 1809 mRNA 0.48 10 36666662 36680531

Neighbor

gene id symbol gene type direction distance location
XLOC_006806 sos2 coding downstream 3304 36638955 ~ 36663358 (-)
XLOC_006805 cdkn3 coding downstream 44736 36612930 ~ 36621926 (-)
XLOC_006804 BX927407.1 coding downstream 54503 36587770 ~ 36612159 (-)
XLOC_006803 lgals3a coding downstream 84321 36568635 ~ 36582341 (-)
XLOC_006802 synj2bp coding downstream 100402 36557205 ~ 36566260 (-)
XLOC_006808 cdkl1 coding upstream 12621 36693152 ~ 36703164 (-)
XLOC_006809 map4k5 coding upstream 25064 36705595 ~ 36761454 (-)
XLOC_006810 sav1 coding upstream 106546 36787077 ~ 36798204 (-)
XLOC_006811 nin coding upstream 119803 36800334 ~ 36844945 (-)
XLOC_006812 pygl coding upstream 166258 36846789 ~ 36863039 (-)
XLOC_006471 BX537274.2 misc downstream 26401757 10264741 ~ 10264905 (-)
XLOC_006338 rn7sk misc downstream 35840437 825904 ~ 826225 (-)
XLOC_006797 CR361558.1 non-coding downstream 267287 36399260 ~ 36399375 (-)
XLOC_006785 BX510990.1 non-coding downstream 704196 35962350 ~ 35962466 (-)
XLOC_006784 NA non-coding downstream 741178 35925042 ~ 35925484 (-)
XLOC_006779 BX663524.1 non-coding downstream 1074285 35592242 ~ 35592377 (-)
XLOC_006814 NA non-coding upstream 315102 36995633 ~ 36997760 (-)
XLOC_006815 NA non-coding upstream 329281 37009812 ~ 37012236 (-)
XLOC_006817 NA non-coding upstream 429681 37110212 ~ 37110536 (-)
XLOC_006819 AL845493.1 non-coding upstream 498071 37178602 ~ 37178716 (-)
XLOC_006829 NA non-coding upstream 847630 37528161 ~ 37535785 (-)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000012_05085822_05090635 L2HGDH coding CI01000012 null 5085103 ~ 5090910 (+)