LOC103046974 (itm2b,LOC108430053)


Basic Information

Item Value
gene id LOC103046974
gene name itm2b,LOC108430053
gene type coding
species mexican tetra (Astyanax mexicanus)
category of species ornamental fish

Chromosome Information

Item Value
chromosome id NC_035906.1
NCBI id CM008309.1
chromosome length 35377769
location 8524435 ~ 8536857 (-)
genome version Astyanax_mexicanus-2.0_2017_mexican_tetra_Genome

Sequence

>XM_007248859.3
CACACAGTAAGTTGAAAGCAGGAGCAGAAATTGTCCCGACAGAGGCCAGGAGACCCAGTACAACTTAGCGGAGgactgctgttgtttttctcacAGTCAGGCAGGCAGTCAGCCATGGTTAAACTAGCCTTTAACTCGGCTCTGAGCCAGAAAGATGTGAAGAAGGACGAAAAGGATGAAGCTCTGATTCCTCAGGAAGGGGATGTAGAGGAGGTTCTGCGGGTCAGGCAGCAGTCCCGGGCATTTTGTTGGTGCATGTGCCTGGGTTTGGCTCTCATGCTGTCTGGAGTTGTTGTCGGCGGAGCTTACCTGTACAGGTATTATATCCTAGAGGTTAAACAAAGGGCCGCTGCTAAAGTTGGCGATGTTCTTCAGGAGCAGAACACGTACTTCTGTGGAGTAAATTACATTGAGGAACAGTACATGATGAAAGACAGCGCAGAAGACACTCCAATCTCAGACATGCGGGTGGATGAGCGTGTCCGGGTGCTGACCGAGGAGGAAGTGGCTCTTATCCATGTTCCAGTGCCGGAATTCAGTGACAGTGACCCCGCTGACATCGTTCACGACTTCAACAAGAAACTGACTGCCTATCTGGACCTGAGCCTAAATAAGTGCTATGTCATCCCTCTCAATACCTCCATCGTCATGCCCCCCAAGGACTTCCTGGAGCTGCTTGTCAACATCAAGGCTGGCACCTACCTGCCACAGTCCTACCTGGTACACGAGCAGATGGTTGTTACGGAGAAGGTGGAGCACGTGGAGCAGCTGGGCTACTTTATCTATAGCCTGTGCAGAGGCAGAGACACTTACAGACTACAGCGCAGGAGCACCATAGCAGGCATTCAGAAACGCGAGGCCCTCGACTGCCACAAGATTCGCCACTTTGAGAACAAGTTTGTGGTGGAGACCCTGATCTGTGAGCAGTAGAGCGACGGCGCCCCTGCCAGAAGCATTACAAACCACTTCTGACGAATTCTGCCGTGCAGTGCAGTGATTATATATGGGGCCCCGCCCACCTCTACTTCTTTCCTTTTAAAGCTCATCCTGTCTCCCATGTGTGGTGGTCTGCTTTGTGTCCCTTTTTTCTGTACAGCgaagatgataatgatgatgaagcAAAGTGAGAAAGAACGAATGGAAGAGAACGAGACTAAAAGCCCTTTTAAAAGCTGATTGTGGCGCGTTTGAACTGTAAGTTTAAAtccctttctgtttctcttttaggATGGATTTAAATCTCCATGTTTGGTTGTTCGTttgatgtttttagttttactttttgttGCAAGCGTTCATTAAGGAGAACAGATTACGGGACATGATTTTTGAAGCATATTCTCATAAATTGGGGATATAAAGAATGTTTGTTAAAGTATATGTTTGATAAAGAGGCAATAAAATCGCTGTTTTGTCTTTGTTTAAACTGTGAAACTCTGTCACAGCCTAGTTCACCATATTATACACTGGAAGATATTAGATTACGATTATGTAGGACATAGCCATTAATGGActataaacatttttgtattagatatactttgttttttaactggttaaaatattaaaccGGTGCTGAAATGTTTTCTTAAGACGTGGTGACGAACAGGGATGCTTTATTTCTAGGCTTCAACAAGCTCTAAGATGCACcagtcagccataacattaaaaccacctttCACAGATTGTTTCCCAAAGTGTAGGCTGAAATTTACTGGCAAAGGAGGATGTTCCACAGTAAAGGATCCTTTATAAACTGGATCCTTTATAAAATggcgcagctgatgtatcctttgcGGCGCTCGGTTAGAAGggggggaaaaaaggaaaatggcACCAGGAACATTGGGCCAAAATATAAGGAAACTCTTCATAGGATGGATGTCAGCCTTGATTTGAATGCAGTTACTGCATAGGTCCCCCTTGTGCCAAAACAGCTCCTCTGAAGGGcctctgaaggtgtcctgtggtatctgtagtcgTGTGGTGATACTTCCATAGATTGCATCAGTGAACCCTAGGCACCAATAAAGTGTAGCCAGGTAATGGCGATACCATGTGCATTACGATACAGgggttatgattcaatatattgtgatatattgtgatactgtaagcaaggatgatatattgtgattgtgtaaaaaaaaaaaaaaaactataattttttttaaataaagtcaaGTAAAAGTCGCTGCTCTATTTGAAATAAACCAAGGTCTGACTCTAATCTATACATGTAAACTAATTCAAAAATTAAGACTGttattgaaaattatttcagtattgcaaaacaaaatatctcaATGCTTCAGTATACCAATATTTTCTTACCACCCCTATATGTCTTTCATTTCAcctgtcagtggttttaatgttatggctgattagcCTATATAAGATTTAAAAGGAAGAGAAAATTCTAATTTCAGGCTATAAGAATTTCAGTTATTCGTGACGATGCAGAAATATTATGCGATACTTCAGAGCGCGTATGTTGAATGTGTAAAGGTTTGTATCTGAATTCTATCACAAATGTCTATAACTGTTGAACTCAAGTTGTATTGATCAACCAATATAATGTGTATAACATTTACATAATGCAAACAATTAAATGTCAATGGATTAACACAATAAAACCTGAACCACTGAA
>XM_007248860.3
ACACAGTAAGTTGAAAGCAGGAGCAGAAATTGTCCCGACAGAGGCCAGGAGACCCAGTACAACTTAGCGGAGgactgctgttgtttttctcacAGTCAGGCAGGCAGTCAGCCATGGTTAAACTAGCCTTTAACTCGGCTCTGAGCCAGAAAGATGTGAAGAAGGACGAAAAGGATGAAGCTCTGATTCCTCAGGAAGGGGATGTAGAGGAGGTTCTGCGGGTCAGGCAGCAGTCCCGGGCATTTTGTTGGTGCATGTGCCTGGGTTTGGCTCTCATGCTGTCTGGAGTTGTTGTCGGCGGAGCTTACCTGTACAGGTATTATATCCTAGAGGAGCAGAACACGTACTTCTGTGGAGTAAATTACATTGAGGAACAGTACATGATGAAAGACAGCGCAGAAGACACTCCAATCTCAGACATGCGGGTGGATGAGCGTGTCCGGGTGCTGACCGAGGAGGAAGTGGCTCTTATCCATGTTCCAGTGCCGGAATTCAGTGACAGTGACCCCGCTGACATCGTTCACGACTTCAACAAGAAACTGACTGCCTATCTGGACCTGAGCCTAAATAAGTGCTATGTCATCCCTCTCAATACCTCCATCGTCATGCCCCCCAAGGACTTCCTGGAGCTGCTTGTCAACATCAAGGCTGGCACCTACCTGCCACAGTCCTACCTGGTACACGAGCAGATGGTTGTTACGGAGAAGGTGGAGCACGTGGAGCAGCTGGGCTACTTTATCTATAGCCTGTGCAGAGGCAGAGACACTTACAGACTACAGCGCAGGAGCACCATAGCAGGCATTCAGAAACGCGAGGCCCTCGACTGCCACAAGATTCGCCACTTTGAGAACAAGTTTGTGGTGGAGACCCTGATCTGTGAGCAGTAGAGCGACGGCGCCCCTGCCAGAAGCATTACAAACCACTTCTGACGAATTCTGCCGTGCAGTGCAGTGATTATATATGGGGCCCCGCCCACCTCTACTTCTTTCCTTTTAAAGCTCATCCTGTCTCCCATGTGTGGTGGTCTGCTTTGTGTCCCTTTTTTCTGTACAGCgaagatgataatgatgatgaagcAAAGTGAGAAAGAACGAATGGAAGAGAACGAGACTAAAAGCCCTTTTAAAAGCTGATTGTGGCGCGTTTGAACTGTAAGTTTAAAtccctttctgtttctcttttaggATGGATTTAAATCTCCATGTTTGGTTGTTCGTttgatgtttttagttttactttttgttGCAAGCGTTCATTAAGGAGAACAGATTACGGGACATGATTTTTGAAGCATATTCTCATAAATTGGGGATATAAAGAATGTTTGTTAAAGTATATGTTTGATAAAGAGGCAATAAAATCGCTGTTTTGTCTTTGTTTAAACTGTGAAACTCTGTCACAGCCTAGTTCACCATATTATACACTGGAAGATATTAGATTACGATTATGTAGGACATAGCCATTAATGGActataaacatttttgtattagatatactttgttttttaactggttaaaatattaaaccGGTGCTGAAATGTTTTCTTAAGACGTGGTGACGAACAGGGATGCTTTATTTCTAGGCTTCAACAAGCTCTAAGATGCACcagtcagccataacattaaaaccacctttCACAGATTGTTTCCCAAAGTGTAGGCTGAAATTTACTGGCAAAGGAGGATGTTCCACAGTAAAGGATCCTTTATAAACTGGATCCTTTATAAAATggcgcagctgatgtatcctttgcGGCGCTCGGTTAGAAGggggggaaaaaaggaaaatggcACCAGGAACATTGGGCCAAAATATAAGGAAACTCTTCATAGGATGGATGTCAGCCTTGATTTGAATGCAGTTACTGCATAGGTCCCCCTTGTGCCAAAACAGCTCCTCTGAAGGGcctctgaaggtgtcctgtggtatctgtagtcgTGTGGTGATACTTCCATAGATTGCATCAGTGAACCCTAGGCACCAATAAAGTGTAGCCAGGTAATGGCGATACCATGTGCATTACGATACAGgggttatgattcaatatattgtgatatattgtgatactgtaagcaaggatgatatattgtgattgtgtaaaaaaaaaaaaaaaactataattttttttaaataaagtcaaGTAAAAGTCGCTGCTCTATTTGAAATAAACCAAGGTCTGACTCTAATCTATACATGTAAACTAATTCAAAAATTAAGACTGttattgaaaattatttcagtattgcaaaacaaaatatctcaATGCTTCAGTATACCAATATTTTCTTACCACCCCTATATGTCTTTCATTTCAcctgtcagtggttttaatgttatggctgattagcCTATATAAGATTTAAAAGGAAGAGAAAATTCTAATTTCAGGCTATAAGAATTTCAGTTATTCGTGACGATGCAGAAATATTATGCGATACTTCAGAGCGCGTATGTTGAATGTGTAAAGGTTTGTATCTGAATTCTATCACAAATGTCTATAACTGTTGAACTCAAGTTGTATTGATCAACCAATATAATGTGTATAACATTTACATAATGCAAACAATTAAATGTCAATGGATTAACACAATAAAACCTGAACCACTGAA

Function

symbol description
itm2b Enables amyloid-beta binding activity. Involved in negative regulation of amyloid precursor protein biosynthetic process. Located in several cellular components, including Golgi apparatus; Golgi-associated vesicle membrane; and extracellular space. Is integral component of organelle membrane. Implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Biomarker of ITM2B-related cerebral amyloid angiopathy 1.

NR:

description
integral membrane protein 2B isoform X1

GO: NA

KEGG:

id description
K18264 ITM2B; integral membrane protein 2B

RNA

RNA id representative length rna type GC content exon number start site end site
XM_007248859.3 True 2653 mRNA 0.42 6 8524435 8536857
XM_007248860.3 False 2610 mRNA 0.42 6 8524435 8536856

Neighbor

gene id symbol gene type direction distance location
LOC103032246 NA coding downstream 45864 8460998 ~ 8478571 (-)
cdk15 cdk15,LOC107706659,LOC107677597 coding downstream 168758 8301794 ~ 8355677 (-)
LOC103024641 fzd7,fzd7b,LOC108430030,LOC107660027,LOC107581350,LOC107706658 coding downstream 257092 8262184 ~ 8267343 (-)
nop58 nop58,LOC107705548,LOC107660025 coding downstream 285307 8230069 ~ 8239128 (-)
wdr12 wdr12,LOC107677607,LOC107706661 coding downstream 315332 8200748 ~ 8209103 (-)
nudt15 LOC107705561,LOC107584789 coding upstream 4618 8541475 ~ 8544605 (-)
LOC103046152 LOC103046152,LOC108430057,LOC108272427,LOC107584782,LOC107705557,LOC107660037 coding upstream 158513 8695370 ~ 8733887 (-)
LOC103046449 NA coding upstream 202028 8738885 ~ 8793825 (-)
LOC103045042 LOC108242159 coding upstream 275547 8812404 ~ 8895438 (-)
LOC103031295 NA coding upstream 475589 9012446 ~ 9015707 (-)
G89176 abi2 non-coding downstream 10596 8508887 ~ 8513839 (-)
G89169 NA non-coding downstream 50695 8472574 ~ 8473740 (-)
G89141 NA non-coding downstream 101644 8419677 ~ 8422791 (-)
G89134 als2 non-coding downstream 120056 8397540 ~ 8404379 (-)
G89135 als2 non-coding downstream 135407 8385432 ~ 8389028 (-)
G89179 NA non-coding upstream 978 8537835 ~ 8538523 (-)
G89288 NA non-coding upstream 413111 8949968 ~ 8950288 (-)
G89299 NA non-coding upstream 471246 9008103 ~ 9018428 (-)
G89322 NA non-coding upstream 544425 9081282 ~ 9082106 (-)
G89328 NA non-coding upstream 554766 9091623 ~ 9130120 (-)
G88789 NA other downstream 1281865 7241711 ~ 7242570 (-)
LOC103026131 LOC108431006 other downstream 1309196 7103571 ~ 7215239 (-)
G88779 NA other downstream 1406309 7117661 ~ 7118126 (-)
vstm2a vstm2a other downstream 1791771 6676275 ~ 6732664 (-)
G88465 NA other downstream 3929110 4595058 ~ 4595325 (-)
LOC103029706 LOC108429024,LOC108268385,LOC107749226,LOC107685514 other upstream 1247766 9784623 ~ 9854099 (-)
G89690 zyx,LOC108428910 other upstream 1357968 9894825 ~ 9901700 (-)
G89708 gapdh,LOC107550818 other upstream 1424425 9961282 ~ 9964606 (-)
LOC103025178 LOC108429038 other upstream 1474960 10011817 ~ 10042853 (-)
G89751 NA other upstream 1686663 10223520 ~ 10224663 (-)

Expression


Co-expression Network