CI01000018_02293913_02296864 (BMI1, BMI1A)


Basic Information

Item Value
gene id CI01000018_02293913_02296864
gene name BMI1, BMI1A
gene type coding
species grasscarp (Ctenopharyngodon idella)
category of species economic fish

Chromosome Information

Item Value
chromosome id CI01000018
NCBI id null
chromosome length 7078422
location 2293790 ~ 2297763 (+)
genome version v1_2015/06_NatureGenetics_grasscarp_Genome

Sequence

>CI01000018_02293913_02296864.mRNA
GCATATAGGCTACGCGGAATGTTCCATTTCAGCTGCTTGGTACGTTGCCATGTAACGCAGCTTTAGTTGCTATAGAAACCGTAAGAAGTGTTCGTCACGTAAACTTAATTTACGTTGAATCTCATGACGGATGCACTATTGACGGGTCTTTTCCATCCCATGACGATGCATCGTACAACAAGGATTAAGATTACAGAGCTCAATCCCCATTTGATGTGTGTCTTGTGTGGTGGATATTTCATAGATGCAACAACAATCATAGAATGCTTGCACTCATTTTGTAAAATGTGCATTGTCCGGTACCTGGAAACCAGTAAATACTGTCCCATATGTGATGTGCAGGTCCACAAAACGAAGCCACTTCTCAATATTCGGTCTGACAAAACTCTACAGGACATTGTATACAAGTTGGTTCCTGGTCTTTTCAAAACTGCAAATGGATCAAATGAGGATCGAGGGGAAGTTGCTGATGAAGACAAGCGAATCATCACAGATGATGAGATTATCAGTCTGTCAATTGAGTTTTTTGATCAAAGGGCCCAACAGCAAGGCTGCACAGATGAGAGGCAAAATGAAGAGGTTAATAATAAAAGATACTTACAATGCCCTGCTGCCATGACTGTGATGCATTTGAGGAAATTTCTGAGAAGCAAAATGGATATACCTCCTACTTTCCAGATTGAAGTTATGTATGAGGATGAGCCTTTGAAGGATTATTACACGTTAATGGACATTGCATACATCTATACATGGAGAAGAAATGGACCATTGCCTCTGAAATACCGCGTGCGGCCCAGCTGTAAAAAAATGAAGATTACCCACCCACAAGATGGCGTGAACAGTACAAACCGCTCTGAAAGCGACTCAGCCAGCGATAAGGCCAGCAGTCCCGCTGGAGTTCCATCCACCTCCTCACCACTACCGAGTCCAAGCACACTGGTTCAGCCTTCACAACCTCACTTCACCCATGTTTCCAACCCTATTAACGGCACGACGATGACAAGCCCAAATCGACAGTTCAGCTTTGGCAACAAAGTGCGAAAGACAGCGCTGAACGGATCTTCCACATCGTCGGGATGATAAGGGACTACAAGATAAAGCCAACGCCAGATATAATCCAGCTATTTCCATGCCAACGTAGTGTCATGTAGAGGCCTTTCTTTTTTGTCATTATTATCAATATATTATACATGTAACTTTAACGTAGTGGAAATGACGCGCTTCATTCGTCACATTGCTGGATTTTCTAAGTTTGTGTGAGAACGTTAGAGGCCCATTTGATTGCAAAGTGGAGCGCAAAGCGACGGTTGCGGCATTTTCAGAATGCAGAAATGACTGAATTATAGCCTACCTTTTTATATATTTTTTACTTTCGGTCTACATTTTCCCTAAACAAATTGCGTTATCTGTTGCTTGTATTTTACATGTGTATTATAACGTTCTTTAAAAGCATGATTAAAAAAAAAAACATTTACTTTGATTCTAGTTTGCCTTTTCTGGGGTAGTTACTAAACATTCCTGGTATATTCTTGCCTTTAATAATGTATCAAAGAAAGGCATATATATAGTTCAAATTTAAATGACAAAAGACTATATTAGGACTGCGTGTTCAAAGGGATAAAGAAATGCAACTTTTAAGTTCTAGTCGGCCTAATAATTTTTTATTATTAGAAGTTCTTGGGAATTCAAGTTTAGTTTTTGCAGTTATTGTACAATATGCTCCACTGTGCCGGTTCGGGGCCGTCAGGTTGGTCTCGAGGTCATAGTCAAGTCTTGTATAGCATGCACACATATCTTTCAGACTGCTTTTCAAGCTATTACATACACGAATTTGTCAGAAGACAAACAGCCACTGTTATACCCCCAACTTCTCATTCTGGACAAGATTTTGATGTCTTCAGTGTTCATTGTCTTATTGGTCGATTGTAGACTATTGACAGCTATTGTATTGTGACTGTTGCACAGTATAAAACATCTAA

Function

symbol description
bmi1a Predicted to enable promoter-specific chromatin binding activity. Acts upstream of or within cerebellum development; hematopoietic stem cell migration; and primitive hemopoiesis. Predicted to be located in nucleus. Predicted to be part of PRC1 complex. Is expressed in eye; gonad; and midbrain hindbrain boundary. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; and hepatocellular carcinoma. Orthologous to several human genes including COMMD3-BMI1 (COMMD3-BMI1 readthrough).
bmi1 Enables RING-like zinc finger domain binding activity; promoter-specific chromatin binding activity; and zinc ion binding activity. Involved in several processes, including histone H2A-K119 monoubiquitination; negative regulation of macromolecule metabolic process; and positive regulation of ubiquitin-protein transferase activity. Located in cytosol and nuclear body. Part of PRC1 complex. Implicated in acute myeloid leukemia; colorectal carcinoma; and hepatocellular carcinoma. Biomarker of esophagus squamous cell carcinoma and pancreatic ductal carcinoma.

GO:

id name namespace
GO:0016569 covalent chromatin modification biological_process

KEGG:

id description
K11459 PCGF4, BMI1; polycomb group RING finger protein 4

RNA

RNA id representative length rna type GC content exon number start site end site
CI01000018_02293913_02296864.mRNA True 1979 mRNA 0.40 9 2293790 2297763

Neighbor

gene id symbol gene type direction distance location
CI01000018_02287327_02289682 NA coding upstream 4074 2286127 ~ 2289716 (+)
CI01000018_02260011_02260307 NA coding upstream 32928 2259902 ~ 2260862 (+)
CI01000018_02205930_02256958 MLLT10 coding upstream 36832 2205212 ~ 2256958 (+)
CI01000018_02203236_02203803 NA coding upstream 89572 2202273 ~ 2204218 (+)
CI01000018_02150486_02181595 PIP4K2AA, PIP4K2AB, PIP4K2A coding upstream 112171 2150486 ~ 2181619 (+)
CI01000018_02299868_02308426 SPAG6.L, SPAG6, PF16, BRAFLDRAFT_281199, SPAG6L coding downstream 2105 2299868 ~ 2308495 (+)
CI01000018_02327424_02330396 NA coding downstream 29661 2327424 ~ 2330960 (+)
CI01000018_02332183_02336865 NA coding downstream 34420 2332183 ~ 2336923 (+)
CI01000018_02338151_02342822 PDIA4 coding downstream 40388 2338151 ~ 2342889 (+)
CI01000018_02344327_02354633 EZH2 coding downstream 46564 2344327 ~ 2355413 (+)
G103363 NA non-coding upstream 157223 2134175 ~ 2136567 (+)
G103347 NA non-coding upstream 210480 2083106 ~ 2083310 (+)
G103386 NA non-coding upstream 333804 1959700 ~ 1959986 (+)
G103385 NA non-coding upstream 335271 1958263 ~ 1958519 (+)
G103384 NA non-coding upstream 335772 1957789 ~ 1958018 (+)
G103457 NA non-coding downstream 8077 2305840 ~ 2306113 (+)
G103478 NA non-coding downstream 80159 2377922 ~ 2378138 (+)
G103479 NA non-coding downstream 80491 2378254 ~ 2378470 (+)
G103480 NA non-coding downstream 81814 2379577 ~ 2379869 (+)
G103482 NA non-coding downstream 86342 2384105 ~ 2384329 (+)
CI01000018_01924489_01985310 SEMA5A other upstream 308479 1924489 ~ 1985311 (+)
G102895 NA other upstream 708128 1582913 ~ 1585662 (+)
G104258 NA other downstream 1393326 3691089 ~ 3691519 (+)
CI01000018_04368179_04375192 NA other downstream 2072423 4368179 ~ 4375866 (+)
G104670 NA other downstream 2458038 4755801 ~ 4759768 (+)
CI01000018_05217404_05218896 NA other downstream 2918917 5216452 ~ 5222616 (+)
G106429 NA other downstream 4583848 6881611 ~ 6886325 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location