XLOC_005709 (gclc)


Basic Information

Item Value
gene id XLOC_005709
gene name gclc
gene type coding
species zebrafish (Danio rerio)
category of species model fish

Chromosome Information

Item Value
chromosome id NC_007124.7
NCBI id CM002897.2
chromosome length 52186027
location 2357637 ~ 2392664 (+)
genome version GRCz11_2017_zebrafish_Genome

Sequence

>TCONS_00011319
CGCTCCCCGCAAGCAAAGTGTCCGTGCGCGAGGAAGAGCCAGACAGACCGAGCTCGCGCACTCTGCGATCAAATATCAGCCTCTCGCCACCGGAGACCCGCTTTATATTCCCCCACATAACGTGAAACCGGAGCCCGTGCTCGACCTGAGAGGATCCGTATTTAAACTCATCGGTATTTAAACCCACTCATATAAGGCCTAGCGTGAGCGCGCGCGCGAGCGAGTTTAACGTTACATTACGTCGGGTTTGTTGTTGCACGTGAAGTGTGCGTAAGTTGACGTAAAGAAGAATACGCTTTTTGGGGGGACCGTAGGTTTTGTGCTATGGGCTTGCTGTCACAGGGGTCACCGCTCAACTGGGAAGAGACCAAGAAACATGCTGACCACGTAAGAAAACACGGCATCCTGCAGTTCCTCAACATCTACAATAAAGTCAAAGACCGGCAGAAGGATGTGCTCAAGTGGGGAGACGAGGTGGAGTACATGTTGGTGAACATGGATGACCAAAATGAAAAAGTCCGCCTAGTTTTGAATGGGAAGGAGGTTTTGGAAATTCTTCAGGAAAAGGGTGAAAACATCAACCCCAACCACCCCACATTGTGGAGGCCTGAGTACGGCAGCTACATGATCGAGGGAACACCGGGTCAGCCGTATGGCGGGACGATGTCGGAGTTCAATACGGTTGAGGATAACATGGGGAAGCGGAGGAGAGAGGCTTCATCTGTGCTCAAGAAGAACGAAACTCTCCTCACAGTCACGGCATTCCCCAGgtTAGGCTGCCCGGGCTTCACCCTGCCGGAGTACAAACCCACACCTGTTGAAAAAGGGGTTTCCAAATCGCTGTTCTTCCCAGACGAGGCCATCAACCGACACCCGAGATTCAGCACTCTGACCAGAAACATCCGCCATCGGAGGGGTGAAAAGGTGGTGATAAACGTACCAATTTTTAAAGATATCAACACCCCGTCTCCATTCATGGAGGTGTTTCCAGAGGATGATGGAGAAGCTGCTCGAGGTGCCAAGCCGGATCACATCTACATGGACGCCATGGGCTTCGGCATGGGGAACTGCTGCCTGCAGGTGACCTTCCAGGCTTGCAGCATCAGTGAGGCTCGATATCTTTACGACCAGCTGGCCACTTTCTGTCCCATAGTGATGGCTCTGAGCGCCGCCTCTCCATTCTATCGGGGTTTTGTGTCCGACATCGACTGCCGCTGGGGTGTTATCTCTGCATCTGTGGATGACCGTACCCGAGAGGAGAGAGGCCTGGAGTCGCTGAAAAACAACAAATTCAGGATCCATAAATCAAGATATGATTCGATCGACAGCTACCTCTCCTGCTGTGGAGAGAAATACAACGACATCGAGCTGACCATAGATGAGGACATCAACAAACAGCTCCTTGATGCAGGCATTGACAAACTGCTGGCGCAGCACATTGCACATCTCTTCATCCGCGACCCGCTGTCGCTCTTCCAGGAGAAGATTCACTTGGATGATGAGAACGAATCGGACCACTTTGAGAACATTCAGTCCACCAACTGGCAGACCATGAGGTTCAAGCCCCCTCCGCCAAACTCTGAGATCGGATGGAGAGTGGAGTTCAGGCCAATGGAGGTCCAGCTGACAGATTTCGAGAACTCTGCTTACGTGGTGTTTATCGTTCTGCTCACCCGCGTCATCCTGTCCTACAAGCTGGATTTCCTCATTCCGTTGTCGAAGGTGGATGAAAATATGAAGGTAGCCCAGAAGCGAAATGCCGTGCAGGAGGGCATGTTTTATTTCCGGAAGGATGTCTTTAAAGGCTGTACCCCAGTGCTGGATCGGCCGGGCGCAGCTCAGAATGGACTGGAGACTGAAACTAATGATGGAGAAGAGTTTATACTGATGAGCATCGACACCATCATCAatggaaagGAAGGGGTTTTTCACGGGCTGATCCCCATGTTGAACAGCTATCTGGAGAACATGGAGGTGGACGTGGACACACGCTGCACAATCCTCAACTACCTGAAACTCATCAAGAAACGAGCTTCAGGTGATCTGATGACCATGGCCAAGTGGATGAGGGAGTTTGTTGCCAAACATCCTCAATATAAGCAGGACAGCGTCATTACAGACAAAATCAACTACGACCTGCTCCACAAGTGTGACAGAATCGCAAAAGGAGAAGAAAAATGTCCAGAACTGATCGGAGAACCGGTCAACAGAGGAAAATGAAGGATAATCATCGCTAATCATATCAAATCATGCGAAAGCTCCTCTGCATGAGAGCGCAAGACCAAGTTTGGGACGCAGCGGTCCAGACAAAGCAACGAAAATGGAAACGTTTTAAgagaatattgattttttttgagTTGTGTTGAATTTGTAAATAGCAGATTTTTTATGACGGGCAAATTATTTTAATAGCTTAAACAGACGCAGGATGTTATTGTACCTGAACGTGTGTACATATTTCACGCCGCTCTGAGCTTGTGCGAGATTATGTAAATGTAGCAAACACTAAATTGTACATTAGTCATATTTTCAATGCcgaaatgtatatactgtacgCCATCAGACAATAACAAGTGTACTttccatttcttttattttttatgaacgaAATTTGCTTATAGTTTTGGCATTTATTAATGAACCGAGACTGAAGACAGTGGGTTCGGTGCAGCACTGACTGATGTAGAAACTAATGCAAGATGACAGTAGAAGCCTTTTAATGGTGTGAAGTGTGTCGTGTCACTAACAGATTTACTTTCATAACTAGTGTTTTTGATGAATATGATATTAGGATATGATTTTCCACCACTAGAGGGAGCACTGGCTCTTTTTTTATGACAGAAATCTATGAAGATCGAGCATTGTTATCTGTATATGGCTTCAGATGAAGTGATTCCTGTACATATTTTCAGCTTACAGAGAGATCTTTTCTAGAGCGCTGTTGAAAATCATTTGCATTCAAGCCTTGCGATTGTTTTGAATGCTGTTTGCCTTGACTGTTTGTCTGTTCAGTAAAACTCTGCTCATTAAATCATTTAATCAGCA

Function

symbol description
gclc Predicted to enable anion binding activity; glutamate-cysteine ligase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including alpha-amino acid metabolic process; cell redox homeostasis; and glutathione biosynthetic process. Predicted to be part of glutamate-cysteine ligase complex. Is expressed in several structures, including alar plate midbrain region; gut; intermediate cell mass of mesoderm; midbrain; and sensory system. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine ligase deficiency; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit).

GO:

id name namespace
GO:0045454 cell redox homeostasis biological_process
GO:0006979 response to oxidative stress biological_process
GO:0043066 negative regulation of apoptotic process biological_process
GO:0006750 glutathione biosynthetic process biological_process
GO:0009408 response to heat biological_process
GO:0045892 negative regulation of transcription, DNA-templated biological_process
GO:0097746 blood vessel diameter maintenance biological_process
GO:0009725 response to hormone biological_process
GO:0006534 cysteine metabolic process biological_process
GO:0006536 glutamate metabolic process biological_process
GO:0017109 glutamate-cysteine ligase complex cellular_component
GO:0004357 glutamate-cysteine ligase activity molecular_function
GO:0016595 glutamate binding molecular_function
GO:0016874 ligase activity molecular_function
GO:0003824 catalytic activity molecular_function
GO:0043531 ADP binding molecular_function
GO:0000287 magnesium ion binding molecular_function

KEGG:

id description
ko00270 Cysteine and methionine metabolism
ko00480 Glutathione metabolism
ko04216 Ferroptosis
ko04212 Longevity regulating pathway - worm

ZFIN:

id description
ZDB-GENE-030131-5056 Predicted to enable anion binding activity; glutamate-cysteine ligase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including alpha-amino acid metabolic process; cell redox homeostasis; and glutathione biosynthetic process. Predicted to be part of glutamate-cysteine ligase complex. Is expressed in several structures, including alar plate midbrain region; gut; intermediate cell mass of mesoderm; midbrain; and sensory system. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine ligase deficiency; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit).

Ensembl:

ensembl_id ENSDARG00000013095

RNA

RNA id representative length rna type GC content exon number start site end site
TCONS_00011319 True 3045 mRNA 0.47 16 2357637 2392664

Neighbor

gene id symbol gene type direction distance location
XLOC_005708 CR376766.2 coding upstream 4642 2352289 ~ 2352995 (+)
XLOC_005707 klhl31 coding upstream 6875 2338761 ~ 2350762 (+)
XLOC_005706 NA coding upstream 204621 2149770 ~ 2153016 (+)
XLOC_005705 NA coding upstream 324594 1983311 ~ 2033043 (+)
XLOC_005704 hmgcll1 coding upstream 375910 1928361 ~ 1981727 (+)
XLOC_005711 elovl5 coding downstream 1600 2394264 ~ 2417409 (+)
XLOC_005712 arfgef3 coding downstream 50177 2442841 ~ 2498321 (+)
XLOC_005713 lhb coding downstream 130368 2523032 ~ 2526033 (+)
XLOC_005714 plpp4 coding downstream 145972 2538636 ~ 2665113 (+)
XLOC_005715 NA coding downstream 278768 2671432 ~ 2676336 (+)
XLOC_005701 CABZ01044297.1 non-coding upstream 592015 1765507 ~ 1765622 (+)
XLOC_005687 NA non-coding upstream 1371374 973009 ~ 986263 (+)
XLOC_005718 BX571701.4 non-coding downstream 440428 2833092 ~ 2833207 (+)
XLOC_005722 NA non-coding downstream 531256 2923920 ~ 2928455 (+)
XLOC_005723 NA non-coding downstream 550617 2943281 ~ 2944990 (+)
XLOC_005725 AL935294.2 non-coding downstream 866879 3259543 ~ 3260961 (+)

Expression


Co-expression Network

Homologous

species gene id symbol gene type chromosome NCBI id location
grasscarp (Ctenopharyngodon idella) CI01000005_05919567_05933578 GCLC coding CI01000005 null 5918402 ~ 5933856 (+)